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Murcko scaffold

1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-phenylpiperazine scaffold

11 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
11
With full pages
5
Scaffold SMILES

O=S(=O)(c1ccc2c(c1)OCCO2)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-phenylpiperazine page
Murcko scaffold O=S(=O)(c1ccc2c(c1)OCCO2)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

6-{[4-(2-Methoxyphenyl)piperazinyl]sulfonyl}-2H,3H-benzo[e]1,4-dioxin chemical structure, C19H22N2O5S, CAS 304684-37-5
6-{[4-(2-Methoxyphenyl)piperazinyl]sulfonyl}-2H,3H-benzo[e]1,4-dioxin
CAS 304684-37-5C19H22N2O5S
1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-phenylpiperazine chemical structure, C18H20N2O4S, CAS 315694-63-4
1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-phenylpiperazine
CAS 315694-63-4C18H20N2O4S
1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(4-methoxyphenyl)piperazine chemical structure, C19H22N2O5S, CAS 432515-51-0
1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(4-methoxyphenyl)piperazine
CAS 432515-51-0C19H22N2O5S
1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(2-fluorophenyl)piperazine chemical structure, C18H19FN2O4S, CAS 431932-54-6
1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(2-fluorophenyl)piperazine
CAS 431932-54-6C18H19FN2O4S
1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(4-fluorophenyl)piperazine chemical structure, C18H19FN2O4S, CAS 432520-72-4
1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(4-fluorophenyl)piperazine
CAS 432520-72-4C18H19FN2O4S
1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C19H19F3N2O4S, CAS 304683-34-9
1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 304683-34-9C19H19F3N2O4S
1-(3,4-Dichlorophenyl)-4-(2,3-dihydro-1,4-benzodioxine-6-sulfonyl)piperazine chemical structure, C18H18Cl2N2O4S, CAS 315709-96-7
1-(3,4-Dichlorophenyl)-4-(2,3-dihydro-1,4-benzodioxine-6-sulfonyl)piperazine
CAS 315709-96-7C18H18Cl2N2O4S
1-(3-Chlorophenyl)-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine chemical structure, C18H19ClN2O4S, CAS 676249-10-8
1-(3-Chlorophenyl)-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine
CAS 676249-10-8C18H19ClN2O4S
1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(2,3-dimethylphenyl)piperazine chemical structure, C20H24N2O4S, CAS 915883-09-9
1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(2,3-dimethylphenyl)piperazine
CAS 915883-09-9C20H24N2O4S
1-(2,5-Dichlorophenyl)-4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)piperazine chemical structure, C18H18Cl2N2O4S, CAS 873675-87-7
1-(2,5-Dichlorophenyl)-4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)piperazine
CAS 873675-87-7C18H18Cl2N2O4S
1-(3-Chloro-2-methylphenyl)-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine chemical structure, C19H21ClN2O4S, CAS 873675-88-8
1-(3-Chloro-2-methylphenyl)-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine
CAS 873675-88-8C19H21ClN2O4S