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Murcko scaffold

1-(Naphthalen-2-ylsulfonyl)-4-phenylpiperazine scaffold

42 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
42
With full pages
4
Scaffold SMILES

O=S(=O)(c1ccc2ccccc2c1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Naphthalen-2-ylsulfonyl)-4-phenylpiperazine page
Murcko scaffold O=S(=O)(c1ccc2ccccc2c1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

1-(6-Ethoxynaphthalen-2-yl)sulfonyl-4-(2-fluorophenyl)piperazine chemical structure, C22H23FN2O3S, CAS 667892-28-6
1-(6-Ethoxynaphthalen-2-yl)sulfonyl-4-(2-fluorophenyl)piperazine
CAS 667892-28-6C22H23FN2O3S
1-(Naphthalen-2-ylsulfonyl)-4-phenylpiperazine chemical structure, C20H20N2O2S, CAS 324777-59-5
1-(Naphthalen-2-ylsulfonyl)-4-phenylpiperazine
CAS 324777-59-5C20H20N2O2S
1-(7-Methylnaphthalen-2-yl)sulfonyl-4-phenylpiperazine chemical structure, C21H22N2O2S, CAS 324777-60-8
1-(7-Methylnaphthalen-2-yl)sulfonyl-4-phenylpiperazine
CAS 324777-60-8C21H22N2O2S
1-(4-Fluorophenyl)-4-[(6-methylnaphthalen-2-yl)sulfonyl]piperazine chemical structure, C21H21FN2O2S, CAS 496014-22-3
1-(4-Fluorophenyl)-4-[(6-methylnaphthalen-2-yl)sulfonyl]piperazine
CAS 496014-22-3C21H21FN2O2S
1-(4-Fluorophenyl)-4-[(6-methoxynaphthalen-2-yl)sulfonyl]piperazine chemical structure, C21H21FN2O3S, CAS 325812-14-4
1-(4-Fluorophenyl)-4-[(6-methoxynaphthalen-2-yl)sulfonyl]piperazine
CAS 325812-14-4C21H21FN2O3S
1-(3-Chloro-4-methylphenyl)-4-[(6-methoxynaphthalen-2-yl)sulfonyl]piperazine chemical structure, C22H23ClN2O3S, CAS 681844-38-2
1-(3-Chloro-4-methylphenyl)-4-[(6-methoxynaphthalen-2-yl)sulfonyl]piperazine
CAS 681844-38-2C22H23ClN2O3S
1-(3,4-Dichlorophenyl)-4-(naphthalen-2-ylsulfonyl)piperazine chemical structure, C20H18Cl2N2O2S, CAS 670270-19-6
1-(3,4-Dichlorophenyl)-4-(naphthalen-2-ylsulfonyl)piperazine
CAS 670270-19-6C20H18Cl2N2O2S
1-(4-Fluorophenyl)-4-(naphthalen-2-ylsulfonyl)piperazine chemical structure, C20H19FN2O2S, CAS 313058-26-3
1-(4-Fluorophenyl)-4-(naphthalen-2-ylsulfonyl)piperazine
CAS 313058-26-3C20H19FN2O2S
1-(2-Fluorophenyl)-4-(2-naphthylsulfonyl)piperazine chemical structure, C20H19FN2O2S, CAS 497060-25-0
1-(2-Fluorophenyl)-4-(2-naphthylsulfonyl)piperazine
CAS 497060-25-0C20H19FN2O2S
1-(2-Methoxyphenyl)-4-(6-methylnaphthalen-2-yl)sulfonylpiperazine chemical structure, C22H24N2O3S, CAS 496014-63-2
1-(2-Methoxyphenyl)-4-(6-methylnaphthalen-2-yl)sulfonylpiperazine
CAS 496014-63-2C22H24N2O3S
1-[(6-Ethoxynaphthalen-2-yl)sulfonyl]-4-phenylpiperazine chemical structure, C22H24N2O3S, CAS 392236-02-1
1-[(6-Ethoxynaphthalen-2-yl)sulfonyl]-4-phenylpiperazine
CAS 392236-02-1C22H24N2O3S
1-Naphthalen-2-ylsulfonyl-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C21H19F3N2O2S, CAS 314244-96-7
1-Naphthalen-2-ylsulfonyl-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 314244-96-7C21H19F3N2O2S
1-(2-Naphthylsulfonyl)-4-(4-nitrophenyl)piperazine chemical structure, C20H19N3O4S, CAS 311763-60-7
1-(2-Naphthylsulfonyl)-4-(4-nitrophenyl)piperazine
CAS 311763-60-7C20H19N3O4S
1-(2-Chloro-4-nitrophenyl)-4-(2-naphthylsulfonyl)piperazine chemical structure, C20H18ClN3O4S, CAS 347318-01-8
1-(2-Chloro-4-nitrophenyl)-4-(2-naphthylsulfonyl)piperazine
CAS 347318-01-8C20H18ClN3O4S
1-(4-Chloro-2-nitrophenyl)-4-naphthalen-2-ylsulfonylpiperazine chemical structure, C20H18ClN3O4S, CAS 347356-26-7
1-(4-Chloro-2-nitrophenyl)-4-naphthalen-2-ylsulfonylpiperazine
CAS 347356-26-7C20H18ClN3O4S
1-(2-Chloro-6-nitrophenyl)-4-naphthalen-2-ylsulfonylpiperazine chemical structure, C20H18ClN3O4S, CAS 430452-60-1
1-(2-Chloro-6-nitrophenyl)-4-naphthalen-2-ylsulfonylpiperazine
CAS 430452-60-1C20H18ClN3O4S
1-(2-Naphthylsulfonyl)-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine chemical structure, C21H18F3N3O4S, CAS 430454-79-8
1-(2-Naphthylsulfonyl)-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine
CAS 430454-79-8C21H18F3N3O4S
1-(2-Naphthylsulfonyl)-4-(2-nitrophenyl)piperazine chemical structure, C20H19N3O4S, CAS 430458-69-8
1-(2-Naphthylsulfonyl)-4-(2-nitrophenyl)piperazine
CAS 430458-69-8C20H19N3O4S
1-Naphthalen-2-ylsulfonyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine chemical structure, C21H18F3N3O4S, CAS 440091-14-5
1-Naphthalen-2-ylsulfonyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine
CAS 440091-14-5C21H18F3N3O4S
1-(4-Methoxyphenyl)-4-(naphthalen-2-ylsulfonyl)piperazine chemical structure, C21H22N2O3S, CAS 494825-74-0
1-(4-Methoxyphenyl)-4-(naphthalen-2-ylsulfonyl)piperazine
CAS 494825-74-0C21H22N2O3S
1-(3-Methoxy-4-nitrophenyl)-4-naphthalen-2-ylsulfonylpiperazine chemical structure, C21H21N3O5S, CAS 524033-50-9
1-(3-Methoxy-4-nitrophenyl)-4-naphthalen-2-ylsulfonylpiperazine
CAS 524033-50-9C21H21N3O5S
2-Methyl-1-naphthalen-2-ylsulfonyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine chemical structure, C22H20F3N3O4S, CAS 524034-06-8
2-Methyl-1-naphthalen-2-ylsulfonyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine
CAS 524034-06-8C22H20F3N3O4S
4-(2-Chloro-4-nitrophenyl)-2-methyl-1-naphthalen-2-ylsulfonylpiperazine chemical structure, C21H20ClN3O4S, CAS 524034-05-7
4-(2-Chloro-4-nitrophenyl)-2-methyl-1-naphthalen-2-ylsulfonylpiperazine
CAS 524034-05-7C21H20ClN3O4S
2-Methyl-1-naphthalen-2-ylsulfonyl-4-(4-nitrophenyl)piperazine chemical structure, C21H21N3O4S, CAS 524034-61-5
2-Methyl-1-naphthalen-2-ylsulfonyl-4-(4-nitrophenyl)piperazine
CAS 524034-61-5C21H21N3O4S