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Murcko scaffold

3-(4-Phenylpiperazine-1-carbonyl)-2H-chromen-2-one scaffold

73 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
73
With full pages
8
Scaffold SMILES

O=C(c1cc2ccccc2oc1=O)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-(4-Phenylpiperazine-1-carbonyl)-2H-chromen-2-one page
Murcko scaffold O=C(c1cc2ccccc2oc1=O)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 73 chemicals

6-Methoxy-3-(4-phenyl-piperazine-1-carbonyl)-chromen-2-one chemical structure, C21H20N2O4, CAS 491870-37-2
6-Methoxy-3-(4-phenyl-piperazine-1-carbonyl)-chromen-2-one
CAS 491870-37-2C21H20N2O4
3-(4-Phenylpiperazine-1-carbonyl)-2H-chromen-2-one chemical structure, C20H18N2O3, CAS 420099-59-8
3-(4-Phenylpiperazine-1-carbonyl)-2H-chromen-2-one
CAS 420099-59-8C20H18N2O3
3-[4-(4-Chlorophenyl)piperazine-1-carbonyl]chromen-2-one chemical structure, C20H17ClN2O3, CAS 540803-37-0
3-[4-(4-Chlorophenyl)piperazine-1-carbonyl]chromen-2-one
CAS 540803-37-0C20H17ClN2O3
3-[4-(4-Fluorophenyl)piperazine-1-carbonyl]chromen-2-one chemical structure, C20H17FN2O3, CAS 541535-61-9
3-[4-(4-Fluorophenyl)piperazine-1-carbonyl]chromen-2-one
CAS 541535-61-9C20H17FN2O3
3-[4-(2-Methoxyphenyl)piperazine-1-carbonyl]-2H-chromen-2-one chemical structure, C21H20N2O4, CAS 380350-74-3
3-[4-(2-Methoxyphenyl)piperazine-1-carbonyl]-2H-chromen-2-one
CAS 380350-74-3C21H20N2O4
6-Bromo-3-{[4-(2-methoxyphenyl)piperazino]carbonyl}-2H-chromen-2-one chemical structure, C21H19BrN2O4, CAS 663928-76-5
6-Bromo-3-{[4-(2-methoxyphenyl)piperazino]carbonyl}-2H-chromen-2-one
CAS 663928-76-5C21H19BrN2O4
3-[4-(3-Chloro-4-methylphenyl)piperazine-1-carbonyl]-6-methoxy-2H-chromen-2-one chemical structure, C22H21ClN2O4, CAS 663929-18-8
3-[4-(3-Chloro-4-methylphenyl)piperazine-1-carbonyl]-6-methoxy-2H-chromen-2-one
CAS 663929-18-8C22H21ClN2O4
3-[4-(3,4-Dimethylphenyl)piperazine-1-carbonyl]-8-methoxy-2H-chromen-2-one chemical structure, C23H24N2O4, CAS 663929-20-2
3-[4-(3,4-Dimethylphenyl)piperazine-1-carbonyl]-8-methoxy-2H-chromen-2-one
CAS 663929-20-2C23H24N2O4
3-[4-(2-Fluorophenyl)piperazine-1-carbonyl]-6-methoxy-2H-chromen-2-one chemical structure, C21H19FN2O4, CAS 663929-22-4
3-[4-(2-Fluorophenyl)piperazine-1-carbonyl]-6-methoxy-2H-chromen-2-one
CAS 663929-22-4C21H19FN2O4
3-[4-(3,4-Dichlorophenyl)piperazine-1-carbonyl]chromen-2-one chemical structure, C20H16Cl2N2O3, CAS 663929-93-9
3-[4-(3,4-Dichlorophenyl)piperazine-1-carbonyl]chromen-2-one
CAS 663929-93-9C20H16Cl2N2O3
6-Bromo-3-{[4-(3-chlorophenyl)piperazino]carbonyl}-2H-chromen-2-one chemical structure, C20H16BrClN2O3, CAS 663930-06-1
6-Bromo-3-{[4-(3-chlorophenyl)piperazino]carbonyl}-2H-chromen-2-one
CAS 663930-06-1C20H16BrClN2O3
6-Bromo-3-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]chromen-2-one chemical structure, C22H21BrN2O3, CAS 663930-07-2
6-Bromo-3-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]chromen-2-one
CAS 663930-07-2C22H21BrN2O3
6-Bromo-3-[4-(4-methylphenyl)piperazine-1-carbonyl]chromen-2-one chemical structure, C21H19BrN2O3, CAS 663938-03-2
6-Bromo-3-[4-(4-methylphenyl)piperazine-1-carbonyl]chromen-2-one
CAS 663938-03-2C21H19BrN2O3
6-Bromo-3-[4-(2-fluorophenyl)piperazine-1-carbonyl]-2H-chromen-2-one chemical structure, C20H16BrFN2O3, CAS 663938-52-1
6-Bromo-3-[4-(2-fluorophenyl)piperazine-1-carbonyl]-2H-chromen-2-one
CAS 663938-52-1C20H16BrFN2O3
3-{[4-(3-Chloro-4-methylphenyl)piperazino]carbonyl}-2H-chromen-2-one chemical structure, C21H19ClN2O3, CAS 663938-53-2
3-{[4-(3-Chloro-4-methylphenyl)piperazino]carbonyl}-2H-chromen-2-one
CAS 663938-53-2C21H19ClN2O3
6-Bromo-3-[4-(3-chloro-4-methylphenyl)piperazine-1-carbonyl]chromen-2-one chemical structure, C21H18BrClN2O3, CAS 663938-69-0
6-Bromo-3-[4-(3-chloro-4-methylphenyl)piperazine-1-carbonyl]chromen-2-one
CAS 663938-69-0C21H18BrClN2O3
3-[4-(2,5-Dimethylphenyl)piperazine-1-carbonyl]-8-prop-2-enylchromen-2-one chemical structure, C25H26N2O3, CAS 693255-29-7
3-[4-(2,5-Dimethylphenyl)piperazine-1-carbonyl]-8-prop-2-enylchromen-2-one
CAS 693255-29-7C25H26N2O3
Chromen-2-one, 3-[4-(3,5-dimethylphenyl)piperazine-1-carbonyl]-8-methoxy- chemical structure, C23H24N2O4, CAS 694497-98-8
Chromen-2-one, 3-[4-(3,5-dimethylphenyl)piperazine-1-carbonyl]-8-methoxy-
CAS 694497-98-8C23H24N2O4
3-{[4-(2-Chlorophenyl)piperazinyl]carbonyl}-6-methoxychromen-2-one chemical structure, C21H19ClN2O4, CAS 797769-83-6
3-{[4-(2-Chlorophenyl)piperazinyl]carbonyl}-6-methoxychromen-2-one
CAS 797769-83-6C21H19ClN2O4
6-Chloro-3-{[4-(4-chlorophenyl)piperazinyl]carbonyl}chromen-2-one chemical structure, C20H16Cl2N2O3, CAS 5185-31-9
6-Chloro-3-{[4-(4-chlorophenyl)piperazinyl]carbonyl}chromen-2-one
CAS 5185-31-9C20H16Cl2N2O3
8-Methoxy-3-(4-phenylpiperazine-1-carbonyl)-2H-chromen-2-one chemical structure, C21H20N2O4, CAS 119686-33-8
8-Methoxy-3-(4-phenylpiperazine-1-carbonyl)-2H-chromen-2-one
CAS 119686-33-8C21H20N2O4
8-Methoxy-3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-2H-chromen-2-one chemical structure, C22H22N2O5, CAS 384364-78-7
8-Methoxy-3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-2H-chromen-2-one
CAS 384364-78-7C22H22N2O5
6-Bromo-3-{[4-(4-fluorophenyl)piperazinyl]carbonyl}-8-methoxychromen-2-one chemical structure, C21H18BrFN2O4, CAS 823827-70-9
6-Bromo-3-{[4-(4-fluorophenyl)piperazinyl]carbonyl}-8-methoxychromen-2-one
CAS 823827-70-9C21H18BrFN2O4
3-[4-(4-Fluorophenyl)piperazine-1-carbonyl]-8-methoxy-6-nitro-2H-chromen-2-one chemical structure, C21H18FN3O6, CAS 714262-97-2
3-[4-(4-Fluorophenyl)piperazine-1-carbonyl]-8-methoxy-6-nitro-2H-chromen-2-one
CAS 714262-97-2C21H18FN3O6