CompoundList
Sign in
Murcko scaffold

Ring system with 4 rings and 26 atoms

35 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
35
With full pages
17
Scaffold SMILES

O=C(c1ccc2c(=O)[nH]c(=O)[nH]c2c1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccc2c(=O)[nH]c(=O)[nH]c2c1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

3-Ethyl-7-(4-phenylpiperazine-1-carbonyl)-1H-quinazoline-2,4-dione chemical structure, C21H22N4O3, CAS 578745-22-9
3-Ethyl-7-(4-phenylpiperazine-1-carbonyl)-1H-quinazoline-2,4-dione
CAS 578745-22-9C21H22N4O3
3-Allyl-7-(4-(2,5-dimethylphenyl)piperazine-1-carbonyl)quinazoline-2,4(1H,3H)-dione chemical structure, C24H26N4O3, CAS 892262-61-2
3-Allyl-7-(4-(2,5-dimethylphenyl)piperazine-1-carbonyl)quinazoline-2,4(1H,3H)-dione
CAS 892262-61-2C24H26N4O3
7-{[4-(4-Acetylphenyl)piperazin-1-yl]carbonyl}-3-allylquinazoline-2,4(1H,3H)-dione chemical structure, C24H24N4O4, CAS 892262-45-2
7-{[4-(4-Acetylphenyl)piperazin-1-yl]carbonyl}-3-allylquinazoline-2,4(1H,3H)-dione
CAS 892262-45-2C24H24N4O4
3-Allyl-7-{[4-(3-chlorophenyl)piperazin-1-yl]carbonyl}quinazoline-2,4(1H,3H)-dione chemical structure, C22H21ClN4O3, CAS 892262-29-2
3-Allyl-7-{[4-(3-chlorophenyl)piperazin-1-yl]carbonyl}quinazoline-2,4(1H,3H)-dione
CAS 892262-29-2C22H21ClN4O3
3-(2-Methoxyethyl)-7-{[4-(2-methoxyphenyl)piperazin-1-yl]carbonyl}quinazoline-2,4(1H,3H)-dione chemical structure, C23H26N4O5, CAS 892271-66-8
3-(2-Methoxyethyl)-7-{[4-(2-methoxyphenyl)piperazin-1-yl]carbonyl}quinazoline-2,4(1H,3H)-dione
CAS 892271-66-8C23H26N4O5
3-Pentyl-7-(4-phenylpiperazine-1-carbonyl)quinazoline-2,4(1H,3H)-dione chemical structure, C24H28N4O3, CAS 892265-58-6
3-Pentyl-7-(4-phenylpiperazine-1-carbonyl)quinazoline-2,4(1H,3H)-dione
CAS 892265-58-6C24H28N4O3
7-(4-(3-Chlorophenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione chemical structure, C24H27ClN4O3, CAS 892265-81-5
7-(4-(3-Chlorophenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione
CAS 892265-81-5C24H27ClN4O3
7-(4-(4-Methoxyphenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione chemical structure, C25H30N4O4, CAS 892266-23-8
7-(4-(4-Methoxyphenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione
CAS 892266-23-8C25H30N4O4
7-(3-Methyl-4-(m-tolyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione chemical structure, C26H32N4O3, CAS 892266-84-1
7-(3-Methyl-4-(m-tolyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione
CAS 892266-84-1C26H32N4O3
7-(4-(5-Chloro-2-methylphenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione chemical structure, C25H29ClN4O3, CAS 892266-92-1
7-(4-(5-Chloro-2-methylphenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione
CAS 892266-92-1C25H29ClN4O3
3-Pentyl-7-(4-(3-(trifluoromethyl)phenyl)piperazine-1-carbonyl)quinazoline-2,4(1H,3H)-dione chemical structure, C25H27F3N4O3, CAS 892267-00-4
3-Pentyl-7-(4-(3-(trifluoromethyl)phenyl)piperazine-1-carbonyl)quinazoline-2,4(1H,3H)-dione
CAS 892267-00-4C25H27F3N4O3
7-(4-(3-Methoxyphenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione chemical structure, C25H30N4O4, CAS 892267-08-2
7-(4-(3-Methoxyphenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione
CAS 892267-08-2C25H30N4O4
3-(2-Methoxyethyl)-7-(4-phenylpiperazine-1-carbonyl)quinazoline-2,4(1H,3H)-dione chemical structure, C22H24N4O4, CAS 892271-36-2
3-(2-Methoxyethyl)-7-(4-phenylpiperazine-1-carbonyl)quinazoline-2,4(1H,3H)-dione
CAS 892271-36-2C22H24N4O4
7-(4-(4-Fluorophenyl)piperazine-1-carbonyl)-3-(2-methoxyethyl)quinazoline-2,4(1H,3H)-dione chemical structure, C22H23FN4O4, CAS 892271-50-0
7-(4-(4-Fluorophenyl)piperazine-1-carbonyl)-3-(2-methoxyethyl)quinazoline-2,4(1H,3H)-dione
CAS 892271-50-0C22H23FN4O4
7-(4-(4-Chlorophenyl)piperazine-1-carbonyl)-3-(2-methoxyethyl)quinazoline-2,4(1H,3H)-dione chemical structure, C22H23ClN4O4, CAS 892272-38-7
7-(4-(4-Chlorophenyl)piperazine-1-carbonyl)-3-(2-methoxyethyl)quinazoline-2,4(1H,3H)-dione
CAS 892272-38-7C22H23ClN4O4
7-(4-(2-Fluorophenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione chemical structure, C24H27FN4O3, CAS 892288-13-0
7-(4-(2-Fluorophenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione
CAS 892288-13-0C24H27FN4O3
7-(4-(2,3-Dimethylphenyl)piperazine-1-carbonyl)-3-(2-methoxyethyl)quinazoline-2,4(1H,3H)-dione chemical structure, C24H28N4O4, CAS 892272-30-9
7-(4-(2,3-Dimethylphenyl)piperazine-1-carbonyl)-3-(2-methoxyethyl)quinazoline-2,4(1H,3H)-dione
CAS 892272-30-9C24H28N4O4
7-(4-(2-Fluorophenyl)piperazine-1-carbonyl)-3-(2-methoxyethyl)quinazoline-2,4(1H,3H)-dione chemical structure, C22H23FN4O4, CAS 892289-56-4
7-(4-(2-Fluorophenyl)piperazine-1-carbonyl)-3-(2-methoxyethyl)quinazoline-2,4(1H,3H)-dione
CAS 892289-56-4C22H23FN4O4
7-(4-(2-Methoxyphenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione chemical structure, C25H30N4O4, CAS 892265-88-2
7-(4-(2-Methoxyphenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione
CAS 892265-88-2C25H30N4O4
3-Allyl-7-(4-(4-fluorophenyl)piperazine-1-carbonyl)quinazoline-2,4(1H,3H)-dione chemical structure, C22H21FN4O3, CAS 892263-17-1
3-Allyl-7-(4-(4-fluorophenyl)piperazine-1-carbonyl)quinazoline-2,4(1H,3H)-dione
CAS 892263-17-1C22H21FN4O3
7-(4-(4-Nitrophenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione chemical structure, C24H27N5O5, CAS 892267-16-2
7-(4-(4-Nitrophenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione
CAS 892267-16-2C24H27N5O5
3-(2-Methoxyethyl)-7-(4-(4-methoxyphenyl)piperazine-1-carbonyl)quinazoline-2,4(1H,3H)-dione chemical structure, C23H26N4O5, CAS 950276-70-7
3-(2-Methoxyethyl)-7-(4-(4-methoxyphenyl)piperazine-1-carbonyl)quinazoline-2,4(1H,3H)-dione
CAS 950276-70-7C23H26N4O5
7-(4-(4-Acetylphenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione chemical structure, C26H30N4O4, CAS 892266-52-3
7-(4-(4-Acetylphenyl)piperazine-1-carbonyl)-3-pentylquinazoline-2,4(1H,3H)-dione
CAS 892266-52-3C26H30N4O4
7-[4-(3-Chlorophenyl)piperazine-1-carbonyl]-3-(2-methoxyethyl)-1H-quinazoline-2,4-dione chemical structure, C22H23ClN4O4, CAS 892271-58-8
7-[4-(3-Chlorophenyl)piperazine-1-carbonyl]-3-(2-methoxyethyl)-1H-quinazoline-2,4-dione
CAS 892271-58-8C22H23ClN4O4