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Murcko scaffold

Ring system with 4 rings and 21 atoms

74 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 21
Chemicals: 74
With full pages: 1

Scaffold SMILES

O=c1c(-c2ccccc2)coc2c3c(ccc12)OCNC3

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c(-c2ccccc2)coc2c3c(ccc12)OCNC3

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 74 chemicals

9-Isopropyl-3-(4-methoxyphenyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C21H21NO4, CAS 929846-03-7

9-Isopropyl-3-(4-methoxyphenyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 929846-03-7C₂₁H₂₁NO₄

9-Isobutyl-3-phenyl-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C21H21NO3, CAS 951995-98-5

9-Isobutyl-3-phenyl-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951995-98-5C₂₁H₂₁NO₃

3-(4-Methoxyphenyl)-9-(3-methoxypropyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C22H23NO5, CAS 946235-95-6

3-(4-Methoxyphenyl)-9-(3-methoxypropyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 946235-95-6C₂₂H₂₃NO₅

9-(3-Methoxypropyl)-3-phenyl-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C21H21NO4, CAS 951954-06-6

9-(3-Methoxypropyl)-3-phenyl-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951954-06-6C₂₁H₂₁NO₄

9-(2-Methoxyethyl)-3-(4-methoxyphenyl)-2-(trifluoromethyl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one chemical structure, C22H20F3NO5, CAS 951976-54-8

9-(2-Methoxyethyl)-3-(4-methoxyphenyl)-2-(trifluoromethyl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one

CAS 951976-54-8C₂₂H₂₀F₃NO₅

3-(2-Methoxyphenyl)-9-(3-methoxypropyl)-2-(trifluoromethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C23H22F3NO5, CAS 951933-27-0

3-(2-Methoxyphenyl)-9-(3-methoxypropyl)-2-(trifluoromethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951933-27-0C₂₃H₂₂F₃NO₅

9-(2-Methoxyethyl)-3-(4-methoxyphenyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C21H21NO5, CAS 951938-26-4

9-(2-Methoxyethyl)-3-(4-methoxyphenyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951938-26-4C₂₁H₂₁NO₅

3-(4-Methoxyphenyl)-9-(3-methoxypropyl)-2-(trifluoromethyl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one chemical structure, C23H22F3NO5, CAS 951940-11-7

3-(4-Methoxyphenyl)-9-(3-methoxypropyl)-2-(trifluoromethyl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one

CAS 951940-11-7C₂₃H₂₂F₃NO₅

9-(3-Methoxypropyl)-3-phenyl-2-(trifluoromethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C22H20F3NO4, CAS 951986-68-8

9-(3-Methoxypropyl)-3-phenyl-2-(trifluoromethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951986-68-8C₂₂H₂₀F₃NO₄

3-(4-Chlorophenyl)-9-isopropyl-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C20H18ClNO3, CAS 951955-24-1

3-(4-Chlorophenyl)-9-isopropyl-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951955-24-1C₂₀H₁₈ClNO₃

9-Isopropyl-3-phenyl-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C20H19NO3, CAS 951980-19-1

9-Isopropyl-3-phenyl-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951980-19-1C₂₀H₁₉NO₃

9-Isobutyl-3-(4-methoxyphenyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C22H23NO4, CAS 951980-73-7

9-Isobutyl-3-(4-methoxyphenyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951980-73-7C₂₂H₂₃NO₄

3-(4-Chlorophenyl)-9-(2-methoxyethyl)-2-(trifluoromethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C21H17ClF3NO4, CAS 951936-50-8

3-(4-Chlorophenyl)-9-(2-methoxyethyl)-2-(trifluoromethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951936-50-8C₂₁H₁₇ClF₃NO₄

3-(3,4-Dimethoxyphenyl)-9-(3-methoxypropyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C23H25NO6, CAS 951959-02-7

3-(3,4-Dimethoxyphenyl)-9-(3-methoxypropyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951959-02-7C₂₃H₂₅NO₆

3-(4-Chlorophenyl)-9-isobutyl-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C21H20ClNO3, CAS 951944-41-5

3-(4-Chlorophenyl)-9-isobutyl-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951944-41-5C₂₁H₂₀ClNO₃

3-(4-Chlorophenyl)-9-(2-methoxyethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C20H18ClNO4, CAS 951960-69-3

3-(4-Chlorophenyl)-9-(2-methoxyethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951960-69-3C₂₀H₁₈ClNO₄

3-(4-Chlorophenyl)-9,10-dihydro-9-(3-methoxypropyl)-4H,8H-pyrano(2,3-f)(1,3)benzoxazin-4-one chemical structure, C21H20ClNO4, CAS 946385-25-7

3-(4-Chlorophenyl)-9,10-dihydro-9-(3-methoxypropyl)-4H,8H-pyrano(2,3-f)(1,3)benzoxazin-4-one

CAS 946385-25-7C₂₁H₂₀ClNO₄

3-(2-Methoxyphenyl)-9-(3-methoxypropyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C22H23NO5, CAS 946385-22-4

3-(2-Methoxyphenyl)-9-(3-methoxypropyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 946385-22-4C₂₂H₂₃NO₅

9-(2-Methoxyethyl)-3-(2-methoxyphenyl)-2-(trifluoromethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C22H20F3NO5, CAS 951950-62-2

9-(2-Methoxyethyl)-3-(2-methoxyphenyl)-2-(trifluoromethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951950-62-2C₂₂H₂₀F₃NO₅

9-(2-Methoxyethyl)-3-phenyl-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one chemical structure, C20H19NO4, CAS 951932-95-9

9-(2-Methoxyethyl)-3-phenyl-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one

CAS 951932-95-9C₂₀H₁₉NO₄

3-(3,4-Dimethoxyphenyl)-9-isobutyl-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C23H25NO5, CAS 951938-55-9

3-(3,4-Dimethoxyphenyl)-9-isobutyl-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951938-55-9C₂₃H₂₅NO₅

9-Isopropyl-3-(2-methoxyphenyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C21H21NO4, CAS 951983-21-4

9-Isopropyl-3-(2-methoxyphenyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951983-21-4C₂₁H₂₁NO₄

3-(3,4-Dimethoxyphenyl)-9-(2-methoxyethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one chemical structure, C22H23NO6, CAS 951954-75-9

3-(3,4-Dimethoxyphenyl)-9-(2-methoxyethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one

CAS 951954-75-9C₂₂H₂₃NO₆

3-(4-Methoxyphenyl)-9-(propan-2-yl)-2-(trifluoromethyl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one chemical structure, C22H20F3NO4, CAS 951994-13-1

3-(4-Methoxyphenyl)-9-(propan-2-yl)-2-(trifluoromethyl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one

CAS 951994-13-1C₂₂H₂₀F₃NO₄