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Murcko scaffold

Ring system with 4 rings and 28 atoms

245 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
245
With full pages
117
Scaffold SMILES

O=C(CSc1nc2ccccc2c(=O)n1-c1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nc2ccccc2c(=O)n1-c1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 245 chemicals

N-(4-Methoxyphenyl)-2-[(4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)sulfanyl]acetamide chemical structure, C23H19N3O3S, CAS 175914-13-3
N-(4-Methoxyphenyl)-2-[(4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)sulfanyl]acetamide
CAS 175914-13-3C23H19N3O3S
N-(4-Fluorophenyl)-2-[(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide chemical structure, C22H16FN3O2S, CAS 256955-31-4
N-(4-Fluorophenyl)-2-[(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide
CAS 256955-31-4C22H16FN3O2S
N-(4-Ethoxyphenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide chemical structure, C25H23N3O3S, CAS 613227-96-6
N-(4-Ethoxyphenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide
CAS 613227-96-6C25H23N3O3S
N-(2-Fluorophenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide chemical structure, C23H18FN3O2S, CAS 474805-57-7
N-(2-Fluorophenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide
CAS 474805-57-7C23H18FN3O2S
N-(3-Chloro-4-methoxyphenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide chemical structure, C24H20ClN3O3S, CAS 613227-98-8
N-(3-Chloro-4-methoxyphenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide
CAS 613227-98-8C24H20ClN3O3S
N-(3-Methoxyphenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide chemical structure, C24H21N3O3S, CAS 499102-40-8
N-(3-Methoxyphenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide
CAS 499102-40-8C24H21N3O3S
N-(3,4-Dimethoxyphenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide chemical structure, C25H23N3O4S, CAS 499102-41-9
N-(3,4-Dimethoxyphenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide
CAS 499102-41-9C25H23N3O4S
N-(2-Ethoxyphenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide chemical structure, C25H23N3O3S, CAS 499102-42-0
N-(2-Ethoxyphenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide
CAS 499102-42-0C25H23N3O3S
N-(3,4-Dimethoxyphenyl)-2-[3-(4-methoxyphenyl)-4-oxoquinazolin-2-yl]sulfanylacetamide chemical structure, C25H23N3O5S, CAS 498546-66-0
N-(3,4-Dimethoxyphenyl)-2-[3-(4-methoxyphenyl)-4-oxoquinazolin-2-yl]sulfanylacetamide
CAS 498546-66-0C25H23N3O5S
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(3,5-dimethoxyphenyl)acetamide chemical structure, C24H20BrN3O4S, CAS 499104-11-9
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(3,5-dimethoxyphenyl)acetamide
CAS 499104-11-9C24H20BrN3O4S
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(4-ethoxyphenyl)acetamide chemical structure, C24H20BrN3O3S, CAS 499104-16-4
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(4-ethoxyphenyl)acetamide
CAS 499104-16-4C24H20BrN3O3S
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(4-fluorophenyl)acetamide chemical structure, C22H15BrFN3O2S, CAS 499104-22-2
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(4-fluorophenyl)acetamide
CAS 499104-22-2C22H15BrFN3O2S
2-[3-(4-Bromophenyl)-4-oxoquinazolin-2-yl]sulfanyl-N-(3-methoxyphenyl)acetamide chemical structure, C23H18BrN3O3S, CAS 499104-26-6
2-[3-(4-Bromophenyl)-4-oxoquinazolin-2-yl]sulfanyl-N-(3-methoxyphenyl)acetamide
CAS 499104-26-6C23H18BrN3O3S
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(3,4-dimethoxyphenyl)acetamide chemical structure, C24H20BrN3O4S, CAS 499104-28-8
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(3,4-dimethoxyphenyl)acetamide
CAS 499104-28-8C24H20BrN3O4S
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(2-ethoxyphenyl)acetamide chemical structure, C24H20BrN3O3S, CAS 499104-31-3
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(2-ethoxyphenyl)acetamide
CAS 499104-31-3C24H20BrN3O3S
N-(4-Methylphenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide chemical structure, C24H21N3O2S, CAS 475418-12-3
N-(4-Methylphenyl)-2-{[3-(4-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide
CAS 475418-12-3C24H21N3O2S
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(4-methoxyphenyl)acetamide chemical structure, C23H18BrN3O3S, CAS 499104-12-0
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(4-methoxyphenyl)acetamide
CAS 499104-12-0C23H18BrN3O3S
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(4-methylphenyl)acetamide chemical structure, C23H18BrN3O2S, CAS 499104-37-9
2-{[3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(4-methylphenyl)acetamide
CAS 499104-37-9C23H18BrN3O2S
N-(2-Chlorophenyl)-2-(4-oxo-3-phenylquinazolin-2-yl)sulfanylacetamide chemical structure, C22H16ClN3O2S, CAS 332860-73-8
N-(2-Chlorophenyl)-2-(4-oxo-3-phenylquinazolin-2-yl)sulfanylacetamide
CAS 332860-73-8C22H16ClN3O2S
N-Methyl-2-(4-oxo-3-phenylquinazolin-2-yl)sulfanyl-N-phenylacetamide chemical structure, C23H19N3O2S, CAS 345988-61-6
N-Methyl-2-(4-oxo-3-phenylquinazolin-2-yl)sulfanyl-N-phenylacetamide
CAS 345988-61-6C23H19N3O2S
N-(5-Chloro-2-methylphenyl)-2-(4-oxo-3-phenylquinazolin-2-yl)sulfanylacetamide chemical structure, C23H18ClN3O2S, CAS 331710-54-4
N-(5-Chloro-2-methylphenyl)-2-(4-oxo-3-phenylquinazolin-2-yl)sulfanylacetamide
CAS 331710-54-4C23H18ClN3O2S
2-(4-Oxo-3-phenylquinazolin-2-yl)sulfanyl-N-(4-propan-2-ylphenyl)acetamide chemical structure, C25H23N3O2S, CAS 311783-01-4
2-(4-Oxo-3-phenylquinazolin-2-yl)sulfanyl-N-(4-propan-2-ylphenyl)acetamide
CAS 311783-01-4C25H23N3O2S
N-(3-Chloro-4-fluorophenyl)-2-[(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide chemical structure, C22H15ClFN3O2S, CAS 329929-27-3
N-(3-Chloro-4-fluorophenyl)-2-[(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide
CAS 329929-27-3C22H15ClFN3O2S
N-(3-CL-PH)-2-((3-(4-CL-Phenyl)-4-oxo-3,4-dihydro-2-quinazolinyl)thio)acetamide chemical structure, C22H15Cl2N3O2S, CAS 380477-54-3
N-(3-CL-PH)-2-((3-(4-CL-Phenyl)-4-oxo-3,4-dihydro-2-quinazolinyl)thio)acetamide
CAS 380477-54-3C22H15Cl2N3O2S