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Murcko scaffold

Ring system with 4 rings and 22 atoms

22 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 22
Chemicals: 22
With full pages: 6

Scaffold SMILES

O=c1c2c(-c3ccccc3)csc2ncn1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c2c(-c3ccccc3)csc2ncn1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

3-(4-Methylphenyl)-5-phenylthieno[2,3-d]pyrimidin-4-one chemical structure, C19H14N2OS, CAS 312946-76-2

3-(4-Methylphenyl)-5-phenylthieno[2,3-d]pyrimidin-4-one

CAS 312946-76-2C₁₉H₁₄N₂OS

5-(2,4-Dimethylphenyl)-3-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-one chemical structure, C21H18N2OS, CAS 312946-78-4

5-(2,4-Dimethylphenyl)-3-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-one

CAS 312946-78-4C₂₁H₁₈N₂OS

3-(4-Methoxyphenyl)-5-phenylthieno[2,3-d]pyrimidin-4-one chemical structure, C19H14N2O2S, CAS 461430-19-3

3-(4-Methoxyphenyl)-5-phenylthieno[2,3-d]pyrimidin-4-one

CAS 461430-19-3C₁₉H₁₄N₂O₂S

3-(3-Methoxyphenyl)-5-phenylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C19H14N2O2S, CAS 445435-60-9

3-(3-Methoxyphenyl)-5-phenylthieno[2,3-d]pyrimidin-4(3H)-one

CAS 445435-60-9C₁₉H₁₄N₂O₂S

3,5-Bis(4-ethoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C22H20N2O3S, CAS 461436-87-3

3,5-Bis(4-ethoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 461436-87-3C₂₂H₂₀N₂O₃S

5-(4-Ethoxyphenyl)-3-(4-methoxyphenyl)thieno[2,3-d]pyrimidin-4-one chemical structure, C21H18N2O3S, CAS 342382-53-0

5-(4-Ethoxyphenyl)-3-(4-methoxyphenyl)thieno[2,3-d]pyrimidin-4-one

CAS 342382-53-0C₂₁H₁₈N₂O₃S

5-(3,4-Dimethoxyphenyl)-3-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-one chemical structure, C21H18N2O3S, CAS 461440-18-6

5-(3,4-Dimethoxyphenyl)-3-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-one

CAS 461440-18-6C₂₁H₁₈N₂O₃S

3-(3-Chlorophenyl)-5-(3,4-dimethoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C20H15ClN2O3S, CAS 446871-32-5

3-(3-Chlorophenyl)-5-(3,4-dimethoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 446871-32-5C₂₀H₁₅ClN₂O₃S

5-(3,4-Dimethoxyphenyl)-3-(4-methoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C21H18N2O4S, CAS 446045-37-0

5-(3,4-Dimethoxyphenyl)-3-(4-methoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 446045-37-0C₂₁H₁₈N₂O₄S

5-(3,4-Dimethoxyphenyl)-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C20H16N2O3S, CAS 461656-06-4

5-(3,4-Dimethoxyphenyl)-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one

CAS 461656-06-4C₂₀H₁₆N₂O₃S

2-(4-Oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetohydrazide chemical structure, C20H16N4O2S2, CAS 312946-37-5

2-(4-Oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetohydrazide

CAS 312946-37-5C₂₀H₁₆N₄O₂S₂

2-((5-(2-Chlorophenyl)-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide chemical structure, C20H14ClN3O2S2, CAS 670273-94-6

2-((5-(2-Chlorophenyl)-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide

CAS 670273-94-6C₂₀H₁₄ClN₃O₂S₂

2-((4-Oxo-3,5-diphenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide chemical structure, C20H15N3O2S2, CAS 354795-44-1

2-((4-Oxo-3,5-diphenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide

CAS 354795-44-1C₂₀H₁₅N₃O₂S₂

5-(4-Chlorophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C19H13ClN2O2S, CAS 461646-73-1

5-(4-Chlorophenyl)-3-(3-methoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 461646-73-1C₁₉H₁₃ClN₂O₂S

2-{[5-(4-Fluorophenyl)-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}acetamide chemical structure, C20H14FN3O2S2, CAS 496023-11-1

2-{[5-(4-Fluorophenyl)-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}acetamide

CAS 496023-11-1C₂₀H₁₄FN₃O₂S₂

5-(4-Fluorophenyl)-2-[(2-oxopropyl)thio]-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C21H15FN2O2S2, CAS 379244-17-4

5-(4-Fluorophenyl)-2-[(2-oxopropyl)thio]-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one

CAS 379244-17-4C₂₁H₁₅FN₂O₂S₂

2-({6-Methyl-4-oxo-3,5-diphenyl-3H,4H-thieno[2,3-d]pyrimidin-2-yl}sulfanyl)acetamide chemical structure, C21H17N3O2S2, CAS 499233-24-8

2-({6-Methyl-4-oxo-3,5-diphenyl-3H,4H-thieno[2,3-d]pyrimidin-2-yl}sulfanyl)acetamide

CAS 499233-24-8C₂₁H₁₇N₃O₂S₂

2-((4-Oxo-3-phenyl-5-(p-tolyl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetic acid chemical structure, C21H16N2O3S2, CAS 374602-13-8

2-((4-Oxo-3-phenyl-5-(p-tolyl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetic acid

CAS 374602-13-8C₂₁H₁₆N₂O₃S₂

Ethyl 2-((4-oxo-3,5-diphenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetate chemical structure, C22H18N2O3S2, CAS 312946-35-3

Ethyl 2-((4-oxo-3,5-diphenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetate

CAS 312946-35-3C₂₂H₁₈N₂O₃S₂

5-(4-Bromophenyl)-3-(4-ethoxyphenyl)thieno[2,3-d]pyrimidin-4-one chemical structure, C20H15BrN2O2S, CAS 312946-84-2

5-(4-Bromophenyl)-3-(4-ethoxyphenyl)thieno[2,3-d]pyrimidin-4-one

CAS 312946-84-2C₂₀H₁₅BrN₂O₂S

N,N-Dimethyl-2-({6-methyl-4-oxo-3,5-diphenyl-3H,4H-thieno[2,3-d]pyrimidin-2-yl}sulfanyl)acetamide chemical structure, C23H21N3O2S2, CAS 500111-79-5

N,N-Dimethyl-2-({6-methyl-4-oxo-3,5-diphenyl-3H,4H-thieno[2,3-d]pyrimidin-2-yl}sulfanyl)acetamide

CAS 500111-79-5C₂₃H₂₁N₃O₂S₂

2-[(Difluoromethyl)sulfanyl]-5-(3,4-dimethoxyphenyl)-3-phenyl-3H,4H-thieno[2,3-d]pyrimidin-4-one, N,N-dimethylacetamide chemical structure, C25H25F2N3O4S2, CAS 353744-46-4

2-[(Difluoromethyl)sulfanyl]-5-(3,4-dimethoxyphenyl)-3-phenyl-3H,4H-thieno[2,3-d]pyrimidin-4-one, N,N-dimethylacetamide

CAS 353744-46-4C₂₅H₂₅F₂N₃O₄S₂