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Murcko scaffold

Ring system with 4 rings and 21 atoms

28 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
28
With full pages
3
Scaffold SMILES

c1ccc(-c2ccn3ncc(-c4ccccc4)c3n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2ccn3ncc(-c4ccccc4)c3n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

5-(4-Fluorophenyl)-2-methyl-3-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H13F4N3, CAS 433942-88-2
5-(4-Fluorophenyl)-2-methyl-3-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 433942-88-2C20H13F4N3
5-(4-Methoxyphenyl)-2-methyl-3-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H16F3N3O, CAS 444144-50-7
5-(4-Methoxyphenyl)-2-methyl-3-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 444144-50-7C21H16F3N3O
5-(3-Methoxyphenyl)-2-methyl-3-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H16F3N3O, CAS 700853-90-3
5-(3-Methoxyphenyl)-2-methyl-3-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 700853-90-3C21H16F3N3O
3-(4-Chlorophenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H11ClF3N3, CAS 529482-38-0
3-(4-Chlorophenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 529482-38-0C19H11ClF3N3
2-Methyl-3,5-diphenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H14F3N3, CAS 299921-86-1
2-Methyl-3,5-diphenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 299921-86-1C20H14F3N3
5-(3-Chlorophenyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H10ClF4N3, CAS 439096-17-0
5-(3-Chlorophenyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 439096-17-0C19H10ClF4N3
3-(4-Fluorophenyl)-5-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine chemical structure, C19H11F4N3, CAS 866019-48-9
3-(4-Fluorophenyl)-5-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine
CAS 866019-48-9C19H11F4N3
5-(4-Chlorophenyl)-2-methyl-3-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H13ClF3N3, CAS 440096-34-4
5-(4-Chlorophenyl)-2-methyl-3-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 440096-34-4C20H13ClF3N3
2-Methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidine-6-carbonitrile chemical structure, C20H14N4, CAS 777867-72-8
2-Methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidine-6-carbonitrile
CAS 777867-72-8C20H14N4
5-(4-Chlorophenyl)-3-(3,4-dimethoxyphenyl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H16ClN3O2, CAS 866144-81-2
5-(4-Chlorophenyl)-3-(3,4-dimethoxyphenyl)pyrazolo[1,5-a]pyrimidine
CAS 866144-81-2C20H16ClN3O2
5-(3-Fluoro-4-methoxyphenyl)-3-(4-fluorophenyl)-6-methylpyrazolo[1,5-a]pyrimidine chemical structure, C20H15F2N3O, CAS 861207-19-4
5-(3-Fluoro-4-methoxyphenyl)-3-(4-fluorophenyl)-6-methylpyrazolo[1,5-a]pyrimidine
CAS 861207-19-4C20H15F2N3O
2-[3-(3,4-Dimethoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl]benzenol chemical structure, C20H17N3O3, CAS 866144-84-5
2-[3-(3,4-Dimethoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl]benzenol
CAS 866144-84-5C20H17N3O3
7-[Chloro(difluoro)methyl]-3-(4-chlorophenyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine chemical structure, C20H10Cl2F5N3, CAS 439097-30-0
7-[Chloro(difluoro)methyl]-3-(4-chlorophenyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine
CAS 439097-30-0C20H10Cl2F5N3
3-(4-Chlorophenyl)-5-(3-fluoro-4-methoxyphenyl)-6-methylpyrazolo[1,5-a]pyrimidine chemical structure, C20H15ClFN3O, CAS 861207-17-2
3-(4-Chlorophenyl)-5-(3-fluoro-4-methoxyphenyl)-6-methylpyrazolo[1,5-a]pyrimidine
CAS 861207-17-2C20H15ClFN3O
5-(3-Fluoro-4-methoxyphenyl)-6-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C20H16FN3O, CAS 861207-37-6
5-(3-Fluoro-4-methoxyphenyl)-6-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 861207-37-6C20H16FN3O
N'-(3,5-Diphenylpyrazolo[1,5-a]pyrimidin-7-yl)-N,N-dimethylethane-1,2-diamine chemical structure, C22H23N5, CAS 900880-85-5
N'-(3,5-Diphenylpyrazolo[1,5-a]pyrimidin-7-yl)-N,N-dimethylethane-1,2-diamine
CAS 900880-85-5C22H23N5
7-Hydrazinyl-3,5-diphenylpyrazolo[1,5-a]pyrimidine chemical structure, C18H15N5, CAS 900870-18-0
7-Hydrazinyl-3,5-diphenylpyrazolo[1,5-a]pyrimidine
CAS 900870-18-0C18H15N5
2-(2-((3,5-Diphenylpyrazolo[1,5-a]pyrimidin-7-yl)amino)ethoxy)ethanol chemical structure, C22H22N4O2, CAS 900900-93-8
2-(2-((3,5-Diphenylpyrazolo[1,5-a]pyrimidin-7-yl)amino)ethoxy)ethanol
CAS 900900-93-8C22H22N4O2
N-[2-(Dimethylamino)ethyl]-2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H25N5, CAS 900897-67-8
N-[2-(Dimethylamino)ethyl]-2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 900897-67-8C23H25N5
N-[3-(Dimethylamino)propyl]-2-methyl-3,5-diphenylpyrazolo[1,5-A]pyrimidin-7-amine chemical structure, C24H27N5, CAS 900894-75-9
N-[3-(Dimethylamino)propyl]-2-methyl-3,5-diphenylpyrazolo[1,5-A]pyrimidin-7-amine
CAS 900894-75-9C24H27N5
3,5-Diphenyl-N-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C21H20N4, CAS 901270-33-5
3,5-Diphenyl-N-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 901270-33-5C21H20N4
7-Hydrazinyl-2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidine chemical structure, C19H17N5, CAS 902045-68-5
7-Hydrazinyl-2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidine
CAS 902045-68-5C19H17N5
2-Methyl-N-(3-methylbutyl)-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C24H26N4, CAS 902010-79-1
2-Methyl-N-(3-methylbutyl)-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 902010-79-1C24H26N4
N-(2-Methoxyethyl)-2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H22N4O, CAS 890624-46-1
N-(2-Methoxyethyl)-2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 890624-46-1C22H22N4O