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Murcko scaffold

Ring system with 4 rings and 21 atoms

52 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 21
Chemicals: 52
With full pages: 4

Scaffold SMILES

c1ccc(-c2ccc3cnn(-c4ccccc4)c3n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(-c2ccc3cnn(-c4ccccc4)c3n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 52 chemicals

3-Methyl-1,6-diphenyl-4-(trifluoromethyl)-1H-pyrazolo(3,4-B)pyridine chemical structure, C20H14F3N3, CAS 428846-07-5

3-Methyl-1,6-diphenyl-4-(trifluoromethyl)-1H-pyrazolo(3,4-B)pyridine

CAS 428846-07-5C₂₀H₁₄F₃N₃

6-(4-Methoxyphenyl)-3-methyl-1-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C21H16F3N3O, CAS 671772-02-4

6-(4-Methoxyphenyl)-3-methyl-1-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

CAS 671772-02-4C₂₁H₁₆F₃N₃O

3-Methyl-1-(4-methylphenyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C21H17N3O2, CAS 749216-18-0

3-Methyl-1-(4-methylphenyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

CAS 749216-18-0C₂₁H₁₇N₃O₂

3-Methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C20H15N3O2, CAS 749218-99-3

3-Methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

CAS 749218-99-3C₂₀H₁₅N₃O₂

6-(4-Methoxyphenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide chemical structure, C21H19N5O2, CAS 380193-14-6

6-(4-Methoxyphenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide

CAS 380193-14-6C₂₁H₁₉N₅O₂

6-(4-Methoxyphenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C21H17N3O3, CAS 380187-39-3

6-(4-Methoxyphenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

CAS 380187-39-3C₂₁H₁₇N₃O₃

6-(4-Bromophenyl)-3-methyl-1-phenyl-4-(trifluoromethyl)pyrazolo[3,4-b]pyridine chemical structure, C20H13BrF3N3, CAS 754997-84-7

6-(4-Bromophenyl)-3-methyl-1-phenyl-4-(trifluoromethyl)pyrazolo[3,4-b]pyridine

CAS 754997-84-7C₂₀H₁₃BrF₃N₃

1-(3-Fluorophenyl)-3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C20H13F4N3, CAS 866142-70-3

1-(3-Fluorophenyl)-3-methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

CAS 866142-70-3C₂₀H₁₃F₄N₃

6-(4-Fluorophenyl)-3-methyl-1-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C20H13F4N3, CAS 737769-63-0

6-(4-Fluorophenyl)-3-methyl-1-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

CAS 737769-63-0C₂₀H₁₃F₄N₃

RefChem:381666 chemical structure, C19H15N3, CAS 198637-57-9

CAS 198637-57-9C₁₉H₁₅N₃

6-(4-Methoxyphenyl)-3-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C22H16F3N3O3, CAS 885457-03-4

6-(4-Methoxyphenyl)-3-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

CAS 885457-03-4C₂₂H₁₆F₃N₃O₃

4-[6-(3,4-Dimethoxyphenyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]benzoic acid chemical structure, C23H18F3N3O4, CAS 900016-16-2

4-[6-(3,4-Dimethoxyphenyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]benzoic acid

CAS 900016-16-2C₂₃H₁₈F₃N₃O₄

6-(3-Methoxyphenyl)-3-methyl-1-phenyl-4-(trifluoromethyl)pyrazolo[3,4-b]pyridine chemical structure, C21H16F3N3O, CAS 792945-05-2

6-(3-Methoxyphenyl)-3-methyl-1-phenyl-4-(trifluoromethyl)pyrazolo[3,4-b]pyridine

CAS 792945-05-2C₂₁H₁₆F₃N₃O

3-Methyl-6-(4-methylphenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine chemical structure, C20H17N3, CAS 890087-24-8

3-Methyl-6-(4-methylphenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine

CAS 890087-24-8C₂₀H₁₇N₃

4-(Difluoromethyl)-6-(2-methoxyphenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine chemical structure, C21H17F2N3O, CAS 832745-96-7

4-(Difluoromethyl)-6-(2-methoxyphenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine

CAS 832745-96-7C₂₁H₁₇F₂N₃O

6-(4-Ethylphenyl)-3-methyl-1-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C22H18F3N3, CAS 832745-97-8

6-(4-Ethylphenyl)-3-methyl-1-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

CAS 832745-97-8C₂₂H₁₈F₃N₃

4-(Difluoromethyl)-3-methyl-6-(4-methylphenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine chemical structure, C21H17F2N3, CAS 832746-01-7

4-(Difluoromethyl)-3-methyl-6-(4-methylphenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine

CAS 832746-01-7C₂₁H₁₇F₂N₃

6-(2-Methoxyphenyl)-3-methyl-1-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C21H16F3N3O, CAS 832746-32-4

6-(2-Methoxyphenyl)-3-methyl-1-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

CAS 832746-32-4C₂₁H₁₆F₃N₃O

Methyl 6-[3-(difluoromethoxy)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate chemical structure, C22H17F2N3O3, CAS 832746-42-6

Methyl 6-[3-(difluoromethoxy)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

CAS 832746-42-6C₂₂H₁₇F₂N₃O₃

4-(Difluoromethyl)-3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine chemical structure, C20H15F2N3, CAS 832746-78-8

4-(Difluoromethyl)-3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine

CAS 832746-78-8C₂₀H₁₅F₂N₃

4-[3-Methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]benzoic acid chemical structure, C21H14F3N3O2, CAS 925087-31-6

4-[3-Methyl-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]benzoic acid

CAS 925087-31-6C₂₁H₁₄F₃N₃O₂

1-(2-Fluorophenyl)-3-methyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C20H14FN3O2, CAS 1011399-61-3

1-(2-Fluorophenyl)-3-methyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

CAS 1011399-61-3C₂₀H₁₄FN₃O₂

1-(4-Fluorophenyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C19H12FN3O2, CAS 1011397-67-3

1-(4-Fluorophenyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

CAS 1011397-67-3C₁₉H₁₂FN₃O₂

4-(4-(Methoxycarbonyl)-3-methyl-6-phenyl-1H-pyrazolo[3,4-b]pyridin-1-yl)benzoic acid chemical structure, C22H17N3O4, CAS 1011398-75-6

4-(4-(Methoxycarbonyl)-3-methyl-6-phenyl-1H-pyrazolo[3,4-b]pyridin-1-yl)benzoic acid

CAS 1011398-75-6C₂₂H₁₇N₃O₄