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Murcko scaffold

Ring system with 4 rings and 22 atoms

342 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
342
With full pages
6
Scaffold SMILES

O=c1[nH]c2cnc(-c3ccccc3)nc2n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]c2cnc(-c3ccccc3)nc2n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 342 chemicals

2-(4-Chlorophenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C18H11ClFN5O2, CAS 869068-76-8
2-(4-Chlorophenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869068-76-8C18H11ClFN5O2
9-(3-Chlorophenyl)-2-(2,3-dimethoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C20H16ClN5O4, CAS 852452-81-4
9-(3-Chlorophenyl)-2-(2,3-dimethoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 852452-81-4C20H16ClN5O4
2-(4-Ethylphenyl)-9-(2-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C21H19N5O3, CAS 869069-37-4
2-(4-Ethylphenyl)-9-(2-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869069-37-4C21H19N5O3
2-(2,4-Dimethoxyphenyl)-9-(2-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C21H19N5O5, CAS 869069-45-4
2-(2,4-Dimethoxyphenyl)-9-(2-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869069-45-4C21H19N5O5
2-(2-Ethoxyphenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C20H16FN5O3, CAS 869069-02-3
2-(2-Ethoxyphenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869069-02-3C20H16FN5O3
2-(2,5-Dimethoxyphenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C20H16FN5O4, CAS 869069-13-6
2-(2,5-Dimethoxyphenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869069-13-6C20H16FN5O4
8-Oxo-2,9-diphenyl-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C18H13N5O2, CAS 389090-50-0
8-Oxo-2,9-diphenyl-8,9-dihydro-7H-purine-6-carboxamide
CAS 389090-50-0C18H13N5O2
8-Oxo-9-phenyl-2-(o-tolyl)-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C19H15N5O2, CAS 887216-81-1
8-Oxo-9-phenyl-2-(o-tolyl)-8,9-dihydro-7H-purine-6-carboxamide
CAS 887216-81-1C19H15N5O2
9-(4-Chlorophenyl)-8-oxo-2-phenyl-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C18H12ClN5O2, CAS 852452-88-1
9-(4-Chlorophenyl)-8-oxo-2-phenyl-8,9-dihydro-7H-purine-6-carboxamide
CAS 852452-88-1C18H12ClN5O2
2,9-Bis(4-chlorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C18H11Cl2N5O2, CAS 863501-35-3
2,9-Bis(4-chlorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 863501-35-3C18H11Cl2N5O2
9-(4-Chlorophenyl)-2-(4-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C19H14ClN5O3, CAS 863501-38-6
9-(4-Chlorophenyl)-2-(4-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 863501-38-6C19H14ClN5O3
9-(4-Chlorophenyl)-2-(3-methylphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C19H14ClN5O2, CAS 852453-10-2
9-(4-Chlorophenyl)-2-(3-methylphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 852453-10-2C19H14ClN5O2
9-(3-Chlorophenyl)-2-(4-nitrophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C18H11ClN6O4, CAS 887887-62-9
9-(3-Chlorophenyl)-2-(4-nitrophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 887887-62-9C18H11ClN6O4
9-(4-Chlorophenyl)-2-(4-nitrophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C18H11ClN6O4, CAS 887888-11-1
9-(4-Chlorophenyl)-2-(4-nitrophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 887888-11-1C18H11ClN6O4
2-(4-Ethoxyphenyl)-9-(3-methylphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C21H19N5O3, CAS 863501-52-4
2-(4-Ethoxyphenyl)-9-(3-methylphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 863501-52-4C21H19N5O3
9-(4-Fluorophenyl)-2-(3-hydroxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C18H12FN5O3, CAS 869068-73-5
9-(4-Fluorophenyl)-2-(3-hydroxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869068-73-5C18H12FN5O3
2-(3,4-Dimethoxyphenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C20H16FN5O4, CAS 869068-78-0
2-(3,4-Dimethoxyphenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869068-78-0C20H16FN5O4
2-(2-Fluorophenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C18H11F2N5O2, CAS 869068-89-3
2-(2-Fluorophenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869068-89-3C18H11F2N5O2
2-(3-Fluorophenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C18H11F2N5O2, CAS 869068-91-7
2-(3-Fluorophenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869068-91-7C18H11F2N5O2
2,9-Bis(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C18H11F2N5O2, CAS 869068-92-8
2,9-Bis(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869068-92-8C18H11F2N5O2
2-(4-Ethylphenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C20H16FN5O2, CAS 869068-93-9
2-(4-Ethylphenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869068-93-9C20H16FN5O2
9-(4-Fluorophenyl)-2-(4-nitrophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C18H11FN6O4, CAS 869068-97-3
9-(4-Fluorophenyl)-2-(4-nitrophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869068-97-3C18H11FN6O4
2-(3-Chlorophenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C18H11ClFN5O2, CAS 869068-99-5
2-(3-Chlorophenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869068-99-5C18H11ClFN5O2
2-(2,4-Dimethoxyphenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide chemical structure, C20H16FN5O4, CAS 869069-01-2
2-(2,4-Dimethoxyphenyl)-9-(4-fluorophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
CAS 869069-01-2C20H16FN5O4