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Murcko scaffold

Ring system with 4 rings and 25 atoms

617 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
617
With full pages
17
Scaffold SMILES

O=C(Nc1ccccc1)c1cc(-c2ccccc2)nc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1cc(-c2ccccc2)nc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 617 chemicals

N-(3,5-Dichlorophenyl)-2-(4-methoxyphenyl)quinoline-4-carboxamide chemical structure, C23H16Cl2N2O2, CAS 332157-16-1
N-(3,5-Dichlorophenyl)-2-(4-methoxyphenyl)quinoline-4-carboxamide
CAS 332157-16-1C23H16Cl2N2O2
N-(3,4-Difluorophenyl)-2-phenylquinoline-4-carboxamide chemical structure, C22H14F2N2O, CAS 303133-50-8
N-(3,4-Difluorophenyl)-2-phenylquinoline-4-carboxamide
CAS 303133-50-8C22H14F2N2O
2-(3-Chlorophenyl)-N-(3,4-dimethylphenyl)-3-methyl-4-quinolinecarboxamide chemical structure, C25H21ClN2O, CAS 438533-03-0
2-(3-Chlorophenyl)-N-(3,4-dimethylphenyl)-3-methyl-4-quinolinecarboxamide
CAS 438533-03-0C25H21ClN2O
N-(4-Fluorophenyl)-2-phenylquinoline-4-carboxamide chemical structure, C22H15FN2O, CAS 349400-18-6
N-(4-Fluorophenyl)-2-phenylquinoline-4-carboxamide
CAS 349400-18-6C22H15FN2O
N-(2-Fluorophenyl)-2-phenylquinoline-4-carboxamide chemical structure, C22H15FN2O, CAS 346726-09-8
N-(2-Fluorophenyl)-2-phenylquinoline-4-carboxamide
CAS 346726-09-8C22H15FN2O
N-Methyl-N,2-diphenylquinoline-4-carboxamide chemical structure, C23H18N2O, CAS 92566-69-3
N-Methyl-N,2-diphenylquinoline-4-carboxamide
CAS 92566-69-3C23H18N2O
N-(4-Chloro-2,5-dimethoxyphenyl)-2-(2,5-dimethylphenyl)quinoline-4-carboxamide chemical structure, C26H23ClN2O3, CAS 350999-39-2
N-(4-Chloro-2,5-dimethoxyphenyl)-2-(2,5-dimethylphenyl)quinoline-4-carboxamide
CAS 350999-39-2C26H23ClN2O3
2-(3-Ethoxyphenyl)-N-(2,3,4-trifluorophenyl)quinoline-4-carboxamide chemical structure, C24H17F3N2O2, CAS 438198-54-0
2-(3-Ethoxyphenyl)-N-(2,3,4-trifluorophenyl)quinoline-4-carboxamide
CAS 438198-54-0C24H17F3N2O2
2-(3,4-Dimethylphenyl)-N-(2,3,4-trifluorophenyl)quinoline-4-carboxamide chemical structure, C24H17F3N2O, CAS 438199-43-0
2-(3,4-Dimethylphenyl)-N-(2,3,4-trifluorophenyl)quinoline-4-carboxamide
CAS 438199-43-0C24H17F3N2O
N-(2,4-Difluorophenyl)-2-(2,5-dimethoxyphenyl)quinoline-4-carboxamide chemical structure, C24H18F2N2O3, CAS 492432-18-5
N-(2,4-Difluorophenyl)-2-(2,5-dimethoxyphenyl)quinoline-4-carboxamide
CAS 492432-18-5C24H18F2N2O3
2-(2,5-Dimethoxyphenyl)-N-(2-fluoro-5-methylphenyl)-4-quinolinecarboxamide chemical structure, C25H21FN2O3, CAS 445260-42-4
2-(2,5-Dimethoxyphenyl)-N-(2-fluoro-5-methylphenyl)-4-quinolinecarboxamide
CAS 445260-42-4C25H21FN2O3
6-Bromo-N-(4-fluorophenyl)-2-phenylquinoline-4-carboxamide chemical structure, C22H14BrFN2O, CAS 444905-75-3
6-Bromo-N-(4-fluorophenyl)-2-phenylquinoline-4-carboxamide
CAS 444905-75-3C22H14BrFN2O
N-(2,4-Dimethoxyphenyl)-2-(2-propan-2-yloxyphenyl)quinoline-4-carboxamide chemical structure, C27H26N2O4, CAS 444905-91-3
N-(2,4-Dimethoxyphenyl)-2-(2-propan-2-yloxyphenyl)quinoline-4-carboxamide
CAS 444905-91-3C27H26N2O4
N-(2-Methoxy-5-nitrophenyl)-2-(3-methylphenyl)quinoline-4-carboxamide chemical structure, C24H19N3O4, CAS 545427-62-1
N-(2-Methoxy-5-nitrophenyl)-2-(3-methylphenyl)quinoline-4-carboxamide
CAS 545427-62-1C24H19N3O4
2-(4-Ethoxyphenyl)-N-(4-methyl-3-nitrophenyl)quinoline-4-carboxamide chemical structure, C25H21N3O4, CAS 544431-03-0
2-(4-Ethoxyphenyl)-N-(4-methyl-3-nitrophenyl)quinoline-4-carboxamide
CAS 544431-03-0C25H21N3O4
Dimethyl 5-({[2-(2-chlorophenyl)-4-quinolinyl]carbonyl}amino)isophthalate chemical structure, C26H19ClN2O5, CAS 544442-84-4
Dimethyl 5-({[2-(2-chlorophenyl)-4-quinolinyl]carbonyl}amino)isophthalate
CAS 544442-84-4C26H19ClN2O5
N-(4-Ethoxyphenyl)-2-(2-methylphenyl)quinoline-4-carboxamide chemical structure, C25H22N2O2, CAS 544662-42-2
N-(4-Ethoxyphenyl)-2-(2-methylphenyl)quinoline-4-carboxamide
CAS 544662-42-2C25H22N2O2
N-(4-Bromo-2-fluorophenyl)-2-(2,4-dimethoxyphenyl)quinoline-4-carboxamide chemical structure, C24H18BrFN2O3, CAS 544669-21-8
N-(4-Bromo-2-fluorophenyl)-2-(2,4-dimethoxyphenyl)quinoline-4-carboxamide
CAS 544669-21-8C24H18BrFN2O3
2-(2,4-Dimethoxyphenyl)-N-(3-fluorophenyl)quinoline-4-carboxamide chemical structure, C24H19FN2O3, CAS 544662-70-6
2-(2,4-Dimethoxyphenyl)-N-(3-fluorophenyl)quinoline-4-carboxamide
CAS 544662-70-6C24H19FN2O3
N-(3-Acetylphenyl)-3-methyl-2-(4-methylphenyl)quinoline-4-carboxamide chemical structure, C26H22N2O2, CAS 544681-87-0
N-(3-Acetylphenyl)-3-methyl-2-(4-methylphenyl)quinoline-4-carboxamide
CAS 544681-87-0C26H22N2O2
N-(4-Fluoro-3-nitrophenyl)-2-(3-methoxyphenyl)quinoline-4-carboxamide chemical structure, C23H16FN3O4, CAS 544450-43-3
N-(4-Fluoro-3-nitrophenyl)-2-(3-methoxyphenyl)quinoline-4-carboxamide
CAS 544450-43-3C23H16FN3O4
N-(3,4-Difluorophenyl)-2-(3,4-dimethoxyphenyl)quinoline-4-carboxamide chemical structure, C24H18F2N2O3, CAS 544460-58-4
N-(3,4-Difluorophenyl)-2-(3,4-dimethoxyphenyl)quinoline-4-carboxamide
CAS 544460-58-4C24H18F2N2O3
2-(3,4-Dimethoxyphenyl)-N-(2-ethoxyphenyl)quinoline-4-carboxamide chemical structure, C26H24N2O4, CAS 547707-54-0
2-(3,4-Dimethoxyphenyl)-N-(2-ethoxyphenyl)quinoline-4-carboxamide
CAS 547707-54-0C26H24N2O4
N-(2-Carbamoylphenyl)-2-(2,4-dichlorophenyl)quinoline-4-carboxamide chemical structure, C23H15Cl2N3O2, CAS 546067-17-8
N-(2-Carbamoylphenyl)-2-(2,4-dichlorophenyl)quinoline-4-carboxamide
CAS 546067-17-8C23H15Cl2N3O2