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Murcko scaffold

N-Phenyl-2-(pyridin-2-yl)quinoline-4-carboxamide scaffold

39 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
39
With full pages
4
Scaffold SMILES

O=C(Nc1ccccc1)c1cc(-c2ccccn2)nc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-Phenyl-2-(pyridin-2-yl)quinoline-4-carboxamide page
Murcko scaffold O=C(Nc1ccccc1)c1cc(-c2ccccn2)nc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 39 of 39 chemicals

8-Chloro-N-(4-fluorophenyl)-2-(2-pyridinyl)-4-quinolinecarboxamide chemical structure, C21H13ClFN3O, CAS 713118-18-4
8-Chloro-N-(4-fluorophenyl)-2-(2-pyridinyl)-4-quinolinecarboxamide
CAS 713118-18-4C21H13ClFN3O
6-Methyl-2-pyridin-2-yl-N-[4-(trifluoromethyl)phenyl]quinoline-4-carboxamide chemical structure, C23H16F3N3O, CAS 713118-23-1
6-Methyl-2-pyridin-2-yl-N-[4-(trifluoromethyl)phenyl]quinoline-4-carboxamide
CAS 713118-23-1C23H16F3N3O
Methyl 2-({[7-chloro-8-methyl-2-(pyridin-2-yl)quinolin-4-yl]carbonyl}amino)-4,5-dimethoxybenzoate chemical structure, C26H22ClN3O5, CAS 713118-60-6
Methyl 2-({[7-chloro-8-methyl-2-(pyridin-2-yl)quinolin-4-yl]carbonyl}amino)-4,5-dimethoxybenzoate
CAS 713118-60-6C26H22ClN3O5
6-Chloro-N-[3-chloro-4-(difluoromethoxy)phenyl]-2-pyridin-2-ylquinoline-4-carboxamide chemical structure, C22H13Cl2F2N3O2, CAS 713118-82-2
6-Chloro-N-[3-chloro-4-(difluoromethoxy)phenyl]-2-pyridin-2-ylquinoline-4-carboxamide
CAS 713118-82-2C22H13Cl2F2N3O2
Methyl 2-[(7-chloro-8-methyl-2-(2-pyridyl)-4-quinolyl)carbonylamino]benzoate chemical structure, C24H18ClN3O3, CAS 713119-03-0
Methyl 2-[(7-chloro-8-methyl-2-(2-pyridyl)-4-quinolyl)carbonylamino]benzoate
CAS 713119-03-0C24H18ClN3O3
Methyl 3-({[6-chloro-2-(pyridin-2-yl)quinolin-4-yl]carbonyl}amino)-4-methylbenzoate chemical structure, C24H18ClN3O3, CAS 713120-74-2
Methyl 3-({[6-chloro-2-(pyridin-2-yl)quinolin-4-yl]carbonyl}amino)-4-methylbenzoate
CAS 713120-74-2C24H18ClN3O3
N-(5-Chloro-2,4-dimethoxyphenyl)-6,8-dimethyl-2-pyridin-2-ylquinoline-4-carboxamide chemical structure, C25H22ClN3O3, CAS 713489-73-7
N-(5-Chloro-2,4-dimethoxyphenyl)-6,8-dimethyl-2-pyridin-2-ylquinoline-4-carboxamide
CAS 713489-73-7C25H22ClN3O3
7-Chloro-N-(3,5-dimethoxyphenyl)-8-methyl-2-pyridin-2-ylquinoline-4-carboxamide chemical structure, C24H20ClN3O3, CAS 713114-69-3
7-Chloro-N-(3,5-dimethoxyphenyl)-8-methyl-2-pyridin-2-ylquinoline-4-carboxamide
CAS 713114-69-3C24H20ClN3O3
Diethyl 5-({[6-methyl-2-(pyridin-2-yl)quinolin-4-yl]carbonyl}amino)benzene-1,3-dicarboxylate chemical structure, C28H25N3O5, CAS 713114-75-1
Diethyl 5-({[6-methyl-2-(pyridin-2-yl)quinolin-4-yl]carbonyl}amino)benzene-1,3-dicarboxylate
CAS 713114-75-1C28H25N3O5
6-Chloro-N-(3,4-dimethoxyphenyl)-2-pyridin-2-ylquinoline-4-carboxamide chemical structure, C23H18ClN3O3, CAS 713115-30-1
6-Chloro-N-(3,4-dimethoxyphenyl)-2-pyridin-2-ylquinoline-4-carboxamide
CAS 713115-30-1C23H18ClN3O3
N-(3-Acetylphenyl)-6-bromo-2-pyridin-2-ylquinoline-4-carboxamide chemical structure, C23H16BrN3O2, CAS 713117-58-9
N-(3-Acetylphenyl)-6-bromo-2-pyridin-2-ylquinoline-4-carboxamide
CAS 713117-58-9C23H16BrN3O2
N-[2-(Difluoromethoxy)-5-methylphenyl]-6-methyl-2-pyridin-2-ylquinoline-4-carboxamide chemical structure, C24H19F2N3O2, CAS 713117-64-7
N-[2-(Difluoromethoxy)-5-methylphenyl]-6-methyl-2-pyridin-2-ylquinoline-4-carboxamide
CAS 713117-64-7C24H19F2N3O2
4-[[Oxo-[2-(2-pyridinyl)-4-quinolinyl]methyl]amino]benzoic acid methyl ester chemical structure, C23H17N3O3, CAS 713117-69-2
4-[[Oxo-[2-(2-pyridinyl)-4-quinolinyl]methyl]amino]benzoic acid methyl ester
CAS 713117-69-2C23H17N3O3
N-(2,4-Dimethoxyphenyl)-2-pyridin-2-ylquinoline-4-carboxamide chemical structure, C23H19N3O3, CAS 377762-51-1
N-(2,4-Dimethoxyphenyl)-2-pyridin-2-ylquinoline-4-carboxamide
CAS 377762-51-1C23H19N3O3
N-(2,5-Dimethoxyphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide chemical structure, C23H19N3O3, CAS 879919-30-9
N-(2,5-Dimethoxyphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide
CAS 879919-30-9C23H19N3O3
N-(4-Methoxyphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide chemical structure, C22H17N3O2, CAS 879919-34-3
N-(4-Methoxyphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide
CAS 879919-34-3C22H17N3O2
N-(4-Chlorophenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide chemical structure, C21H14ClN3O, CAS 879919-38-7
N-(4-Chlorophenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide
CAS 879919-38-7C21H14ClN3O
2-(Pyridin-2-yl)-N-(p-tolyl)quinoline-4-carboxamide chemical structure, C22H17N3O, CAS 879919-40-1
2-(Pyridin-2-yl)-N-(p-tolyl)quinoline-4-carboxamide
CAS 879919-40-1C22H17N3O
N-(3-Chlorophenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide chemical structure, C21H14ClN3O, CAS 879919-42-3
N-(3-Chlorophenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide
CAS 879919-42-3C21H14ClN3O
N-(3-Methylphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide chemical structure, C22H17N3O, CAS 879919-44-5
N-(3-Methylphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide
CAS 879919-44-5C22H17N3O
N-(4-Ethoxyphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide chemical structure, C23H19N3O2, CAS 879919-63-8
N-(4-Ethoxyphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide
CAS 879919-63-8C23H19N3O2
N-[4-(tert-Butylsulfamoyl)phenyl]-2-(pyridin-2-yl)quinoline-4-carboxamide chemical structure, C25H24N4O3S, CAS 879919-96-7
N-[4-(tert-Butylsulfamoyl)phenyl]-2-(pyridin-2-yl)quinoline-4-carboxamide
CAS 879919-96-7C25H24N4O3S
6-Methyl-N-(4-methylphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide chemical structure, C23H19N3O, CAS 890641-81-3
6-Methyl-N-(4-methylphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide
CAS 890641-81-3C23H19N3O
N-(2-Methoxyphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide chemical structure, C22H17N3O2, CAS 951900-62-2
N-(2-Methoxyphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide
CAS 951900-62-2C22H17N3O2