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Murcko scaffold

Ring system with 4 rings and 24 atoms

28 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
28
With full pages
4
Scaffold SMILES

c1ccc(-c2cnn3c(NCCN4CCOCC4)ccnc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cnn3c(NCCN4CCOCC4)ccnc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

3-(4-Chlorophenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H24ClN5O, CAS 849910-86-7
3-(4-Chlorophenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 849910-86-7C20H24ClN5O
2,5-Dimethyl-N-[2-(morpholin-4-yl)ethyl]-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H25N5O, CAS 862197-65-7
2,5-Dimethyl-N-[2-(morpholin-4-yl)ethyl]-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 862197-65-7C20H25N5O
5-Methyl-N-(2-morpholin-4-ylethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C19H23N5O, CAS 850899-97-7
5-Methyl-N-(2-morpholin-4-ylethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 850899-97-7C19H23N5O
3-(4-Chlorophenyl)-5-methyl-N-[2-(morpholin-4-yl)ethyl]pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C19H22ClN5O, CAS 899406-37-2
3-(4-Chlorophenyl)-5-methyl-N-[2-(morpholin-4-yl)ethyl]pyrazolo[1,5-a]pyrimidin-7-amine
CAS 899406-37-2C19H22ClN5O
2-Methyl-N-[2-(morpholin-4-yl)ethyl]-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H29N5O, CAS 899396-69-1
2-Methyl-N-[2-(morpholin-4-yl)ethyl]-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 899396-69-1C22H29N5O
5-tert-Butyl-3-(4-chlorophenyl)-N-[2-(morpholin-4-yl)ethyl]pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H28ClN5O, CAS 899409-52-0
5-tert-Butyl-3-(4-chlorophenyl)-N-[2-(morpholin-4-yl)ethyl]pyrazolo[1,5-a]pyrimidin-7-amine
CAS 899409-52-0C22H28ClN5O
2-Methyl-N-[2-(morpholin-4-yl)ethyl]-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H29N5O, CAS 899410-27-6
2-Methyl-N-[2-(morpholin-4-yl)ethyl]-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 899410-27-6C22H29N5O
5-(tert-Butyl)-N-(2-morpholinoethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H29N5O, CAS 900279-56-3
5-(tert-Butyl)-N-(2-morpholinoethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 900279-56-3C22H29N5O
5-tert-Butyl-2-methyl-N-(2-morpholin-4-ylethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H31N5O, CAS 850801-96-6
5-tert-Butyl-2-methyl-N-(2-morpholin-4-ylethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 850801-96-6C23H31N5O
5-(tert-Butyl)-3-(4-chlorophenyl)-2-methyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H30ClN5O, CAS 877791-71-4
5-(tert-Butyl)-3-(4-chlorophenyl)-2-methyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 877791-71-4C23H30ClN5O
3-(2-Methoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C21H27N5O2, CAS 902041-09-2
3-(2-Methoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 902041-09-2C21H27N5O2
2-Ethyl-5-methyl-N-(2-morpholin-4-ylethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C21H27N5O, CAS 900291-10-3
2-Ethyl-5-methyl-N-(2-morpholin-4-ylethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 900291-10-3C21H27N5O
3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H29N5O3, CAS 900874-91-1
3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 900874-91-1C22H29N5O3
3-(2-Chlorophenyl)-5-methyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C19H22ClN5O, CAS 900900-09-6
3-(2-Chlorophenyl)-5-methyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 900900-09-6C19H22ClN5O
5-Isopropyl-N-(2-morpholinoethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C21H27N5O, CAS 900900-14-3
5-Isopropyl-N-(2-morpholinoethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 900900-14-3C21H27N5O
5-Methyl-N-(2-morpholinoethyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H22F3N5O, CAS 900882-42-0
5-Methyl-N-(2-morpholinoethyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 900882-42-0C20H22F3N5O
N-[2-(Morpholin-4-yl)ethyl]-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C21H27N5O, CAS 900872-03-9
N-[2-(Morpholin-4-yl)ethyl]-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 900872-03-9C21H27N5O
5,6-Dimethyl-N-(2-morpholin-4-ylethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H25N5O, CAS 900888-06-4
5,6-Dimethyl-N-(2-morpholin-4-ylethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 900888-06-4C20H25N5O
2,5-Dimethyl-3-(4-methylphenyl)-N-[2-(morpholin-4-yl)ethyl]pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C21H27N5O, CAS 902037-43-8
2,5-Dimethyl-3-(4-methylphenyl)-N-[2-(morpholin-4-yl)ethyl]pyrazolo[1,5-a]pyrimidin-7-amine
CAS 902037-43-8C21H27N5O
5-Methyl-N-[2-(morpholin-4-yl)ethyl]-3-phenyl-6-(prop-2-en-1-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H27N5O, CAS 902025-80-3
5-Methyl-N-[2-(morpholin-4-yl)ethyl]-3-phenyl-6-(prop-2-en-1-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 902025-80-3C22H27N5O
3-(2-Methoxyphenyl)-5-methyl-N-(2-morpholin-4-ylethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H25N5O2, CAS 902336-45-2
3-(2-Methoxyphenyl)-5-methyl-N-(2-morpholin-4-ylethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 902336-45-2C20H25N5O2
5-Methyl-3-(4-methylphenyl)-N-[2-(morpholin-4-yl)ethyl]pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H25N5O, CAS 900278-62-8
5-Methyl-3-(4-methylphenyl)-N-[2-(morpholin-4-yl)ethyl]pyrazolo[1,5-a]pyrimidin-7-amine
CAS 900278-62-8C20H25N5O
3-(2-Chlorophenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H24ClN5O, CAS 900286-98-8
3-(2-Chlorophenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 900286-98-8C20H24ClN5O
3-(4-Fluorophenyl)-5-methyl-N-[2-(morpholin-4-yl)ethyl]pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C19H22FN5O, CAS 921054-61-7
3-(4-Fluorophenyl)-5-methyl-N-[2-(morpholin-4-yl)ethyl]pyrazolo[1,5-a]pyrimidin-7-amine
CAS 921054-61-7C19H22FN5O