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Murcko scaffold

Ring system with 4 rings and 24 atoms

47 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
47
With full pages
6
Scaffold SMILES

c1ccc(CCNc2ccnc3c(-c4ccccc4)cnn23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CCNc2ccnc3c(-c4ccccc4)cnn23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 47 of 47 chemicals

5-tert-Butyl-3-(4-chlorophenyl)-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C24H25ClN4, CAS 896821-76-4
5-tert-Butyl-3-(4-chlorophenyl)-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896821-76-4C24H25ClN4
2-Methyl-3-phenyl-N-(2-phenylethyl)-5-propylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C24H26N4, CAS 896823-35-1
2-Methyl-3-phenyl-N-(2-phenylethyl)-5-propylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 896823-35-1C24H26N4
3-(4-Chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H23ClN4O2, CAS 896831-13-3
3-(4-Chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 896831-13-3C23H23ClN4O2
5-tert-Butyl-3-phenyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C24H26N4, CAS 896837-81-3
5-tert-Butyl-3-phenyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896837-81-3C24H26N4
2-Methyl-3-phenyl-N-(2-phenylethyl)-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C24H26N4, CAS 899408-04-9
2-Methyl-3-phenyl-N-(2-phenylethyl)-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 899408-04-9C24H26N4
6-Ethyl-2,5-dimethyl-N-phenethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C24H26N4, CAS 899387-48-5
6-Ethyl-2,5-dimethyl-N-phenethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 899387-48-5C24H26N4
3-(4-Chlorophenyl)-5-methyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C21H19ClN4, CAS 900280-78-6
3-(4-Chlorophenyl)-5-methyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 900280-78-6C21H19ClN4
N-[2-(3,4-Dimethoxyphenyl)ethyl]-6-ethyl-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C26H30N4O2, CAS 896593-85-4
N-[2-(3,4-Dimethoxyphenyl)ethyl]-6-ethyl-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 896593-85-4C26H30N4O2
5-tert-Butyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C26H30N4O2, CAS 896594-90-4
5-tert-Butyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 896594-90-4C26H30N4O2
3-(4-Chlorophenyl)-2,5-dimethyl-N-phenethylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H21ClN4, CAS 877786-94-2
3-(4-Chlorophenyl)-2,5-dimethyl-N-phenethylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 877786-94-2C22H21ClN4
N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-(2-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C25H28N4O3, CAS 879575-21-0
N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-(2-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 879575-21-0C25H28N4O3
3-(4-Chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C24H25ClN4O2, CAS 862192-99-2
3-(4-Chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 862192-99-2C24H25ClN4O2
5-tert-Butyl-2-methyl-3-phenyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C25H28N4, CAS 877803-02-6
5-tert-Butyl-2-methyl-3-phenyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 877803-02-6C25H28N4
2,5-Dimethyl-N-phenethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H22N4, CAS 877776-97-1
2,5-Dimethyl-N-phenethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 877776-97-1C22H22N4
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C24H26N4O2, CAS 877647-02-4
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 877647-02-4C24H26N4O2
5-tert-Butyl-3-(4-chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C27H31ClN4O2, CAS 877790-38-0
5-tert-Butyl-3-(4-chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-methylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 877790-38-0C27H31ClN4O2
5-Methyl-3-phenyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C21H20N4, CAS 877788-38-0
5-Methyl-3-phenyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 877788-38-0C21H20N4
N-[2-(3,4-Dimethoxyphenyl)ethyl]-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H24N4O2, CAS 849910-68-5
N-[2-(3,4-Dimethoxyphenyl)ethyl]-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 849910-68-5C23H24N4O2
3-(2-Methoxyphenyl)-2,5-dimethyl-N-phenethylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H24N4O, CAS 879568-29-3
3-(2-Methoxyphenyl)-2,5-dimethyl-N-phenethylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 879568-29-3C23H24N4O
N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-(2-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C24H26N4O3, CAS 879584-94-8
N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-(2-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 879584-94-8C24H26N4O3
2,5-Dimethyl-3-(4-methylphenyl)-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H24N4, CAS 900296-31-3
2,5-Dimethyl-3-(4-methylphenyl)-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 900296-31-3C23H24N4
3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C24H26N4O2, CAS 900259-92-9
3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 900259-92-9C24H26N4O2
N-[2-(3,4-Dimethoxyphenyl)ethyl]-5-methyl-3-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C24H26N4O2, CAS 900892-55-9
N-[2-(3,4-Dimethoxyphenyl)ethyl]-5-methyl-3-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 900892-55-9C24H26N4O2
3-(2-Chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H23ClN4O2, CAS 900879-51-8
3-(2-Chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 900879-51-8C23H23ClN4O2