Murcko scaffold
3-Phenyl-4H-pyrazolo[1,5-a]pyrimidin-7-one scaffold
118 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 16
- Chemicals
- 118
- With full pages
- 29
Scaffold SMILES
O=c1ccnc2c(-c3ccccc3)c[nH]n12
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=c1ccnc2c(-c3ccccc3)c[nH]n12](/scaffold/LQOZGZQLNDEHLB-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 118 chemicals
![Ethyl (2-methyl-7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-5-yl)acetate chemical structure, C17H17N3O3, CAS 726199-64-0](/s/CKWZTVSSDLNIRW-UHFFFAOYSA-N.svg)
Ethyl (2-methyl-7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-5-yl)acetate
CAS 726199-64-0C17H17N3O3
![5-tert-Butyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C17H19N3O, CAS 877798-07-7](/s/PFIUIEAMCBNRQQ-UHFFFAOYSA-N.svg)
5-tert-Butyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 877798-07-7C17H19N3O
![2-Methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C16H17N3O, CAS 879577-69-2](/s/FOIADZGYILOFMN-UHFFFAOYSA-N.svg)
2-Methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 879577-69-2C16H17N3O
![5-Isopropyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C16H17N3O, CAS 879571-05-8](/s/WCXLLXFUHIQSKK-UHFFFAOYSA-N.svg)
5-Isopropyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 879571-05-8C16H17N3O
![3-(4-Chlorophenyl)-6-ethyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7(4H)-one chemical structure, C16H16ClN3O, CAS 432536-07-7](/s/WYSSVOALZWOZOU-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-6-ethyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS 432536-07-7C16H16ClN3O
![6-Ethyl-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C16H17N3O, CAS 296770-69-9](/s/TWBALWJAFBKKCJ-UHFFFAOYSA-N.svg)
6-Ethyl-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 296770-69-9C16H17N3O
![5-(Methoxymethyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one chemical structure, C15H15N3O2, CAS 310422-19-6](/s/HDAUYCPGQKWRPG-UHFFFAOYSA-N.svg)
5-(Methoxymethyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS 310422-19-6C15H15N3O2
![5-Methyl-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C14H10F3N3O, CAS 879577-20-5](/s/CTUVSNSURNBMMJ-UHFFFAOYSA-N.svg)
5-Methyl-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-ol
CAS 879577-20-5C14H10F3N3O
![3-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-7-one chemical structure, C14H12ClN3O, CAS 850764-60-2](/s/KSIQRPQGLOUZIY-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-7-one
CAS 850764-60-2C14H12ClN3O
![3-(4-Chlorophenyl)-2-methyl-5-propyl-1H-pyrazolo[1,5-a]pyrimidin-7-one chemical structure, C16H16ClN3O, CAS 419545-63-4](/s/FRRDLPUGHJSODK-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-2-methyl-5-propyl-1H-pyrazolo[1,5-a]pyrimidin-7-one
CAS 419545-63-4C16H16ClN3O
![Ethyl [3-(4-chlorophenyl)-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]acetate chemical structure, C17H16ClN3O3, CAS 444789-98-4](/s/VJRJFATUDBEHAW-UHFFFAOYSA-N.svg)
Ethyl [3-(4-chlorophenyl)-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]acetate
CAS 444789-98-4C17H16ClN3O3
![Ethyl (2,5-dimethyl-7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)acetate chemical structure, C18H19N3O3, CAS 462618-28-6](/s/JHCKMIKJZMSRBA-UHFFFAOYSA-N.svg)
Ethyl (2,5-dimethyl-7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)acetate
CAS 462618-28-6C18H19N3O3
![5-Methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C13H11N3O, CAS 58347-54-9](/s/XPWLGRQOVGQEJJ-UHFFFAOYSA-N.svg)
5-Methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 58347-54-9C13H11N3O
![3-(4-Chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C13H10ClN3O, CAS 58347-53-8](/s/BBVYTPDJKBELJW-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 58347-53-8C13H10ClN3O
![6-Ethyl-5-methyl-3-phenyl-4H-pyrazolo[1,5-a]pyrimidin-7-one chemical structure, C15H15N3O, CAS 736962-47-3](/s/CGMXDZAGECDQPD-UHFFFAOYSA-N.svg)
6-Ethyl-5-methyl-3-phenyl-4H-pyrazolo[1,5-a]pyrimidin-7-one
CAS 736962-47-3C15H15N3O
![2,5,6-Trimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one chemical structure, C15H15N3O, CAS 879622-94-3](/s/JJGVGYLZAKZQBD-UHFFFAOYSA-N.svg)
2,5,6-Trimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS 879622-94-3C15H15N3O
![3-Phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C15H15N3O, CAS 879770-28-2](/s/ABFBTPWAJOPDLH-UHFFFAOYSA-N.svg)
3-Phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 879770-28-2C15H15N3O
![3-(4-Chlorophenyl)-6-ethyl-5-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one chemical structure, C15H14ClN3O, CAS 509113-27-3](/s/BKYJEMPTDGUJFX-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-6-ethyl-5-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS 509113-27-3C15H14ClN3O
![6-Chloro-3-(4-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7(4H)-one chemical structure, C15H14ClN3O2, CAS 419550-43-9](/s/FETRLYHBVWKUCO-UHFFFAOYSA-N.svg)
6-Chloro-3-(4-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS 419550-43-9C15H14ClN3O2
![3-(2-Methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C15H15N3O2, CAS 895837-56-6](/s/LYVVBLWLHDTGCC-UHFFFAOYSA-N.svg)
3-(2-Methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 895837-56-6C15H15N3O2
![2,5-Dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one chemical structure, C14H13N3O, CAS 138628-48-5](/s/TWAKYLAMMFJNIN-UHFFFAOYSA-N.svg)
2,5-Dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS 138628-48-5C14H13N3O
![Ethyl 2-(7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-5-yl)acetate chemical structure, C16H15N3O3, CAS 527703-81-7](/s/MHSXABBZTYRYKD-UHFFFAOYSA-N.svg)
Ethyl 2-(7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-5-yl)acetate
CAS 527703-81-7C16H15N3O3
![3-(4-Chlorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one chemical structure, C14H9ClF3N3O, CAS 924828-82-0](/s/HZTKWPUYNLCAMY-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS 924828-82-0C14H9ClF3N3O
![5-Ethyl-3-(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one chemical structure, C16H17N3O2, CAS 708224-93-5](/s/QUXXHBMOGSHBBN-UHFFFAOYSA-N.svg)
5-Ethyl-3-(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS 708224-93-5C16H17N3O2
- 6-Ethyl-3-(2-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7(4H)-one701220-61-3C17H19N3O2
- Ethyl 2-(3-(4-chlorophenyl)-2,5-dimethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)acetate531530-70-8C18H18ClN3O3
- 3-(4-Chlorophenyl)-5-propyl-1H-pyrazolo[1,5-a]pyrimidin-7-one419547-36-7C15H14ClN3O
- 3-(4-Chlorophenyl)-5-(methoxymethyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one419550-98-4C15H14ClN3O2
- Ethyl 2-methyl-7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate890007-87-1C16H15N3O3
- Ethyl [3-(3-bromophenyl)-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]acetate462087-85-0C17H16BrN3O3
- 5-(Methoxymethyl)-3-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-ol692287-70-0C15H15N3O3
- Ethyl 3-(3,4-dimethoxyphenyl)-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate860610-81-7C17H17N3O5
- 6-Chloro-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-ol879457-80-4C14H12ClN3O
- 5-tert-Butyl-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-ol896856-18-1C16H16ClN3O
- Methyl (2-methyl-7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-5-yl)acetate899401-97-9C16H15N3O3
- 5-tert-Butyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-ol896077-01-3C16H17N3O
- Ethyl 7-hydroxy-2-methyl-3-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-6-carboxylate852690-95-0C17H14F3N3O3
- 2-(Methoxymethyl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-ol876718-17-1C15H15N3O2
- Ethyl [7-hydroxy-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-5-yl]acetate835889-40-2C17H14F3N3O3
- 3-(3,4-Dimethoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-ol900297-43-0C16H17N3O3
- Ethyl [3-(3,4-dimethoxyphenyl)-7-hydroxy-2-methylpyrazolo[1,5-a]pyrimidin-5-yl]acetate876898-61-2C19H21N3O5
- 3-(4-Methoxyphenyl)-2-methyl-5-propyl-1H-pyrazolo[1,5-a]pyrimidin-7-one419551-46-5C17H19N3O2
- Methyl [3-(4-chlorophenyl)-7-hydroxy-2-methylpyrazolo[1,5-a]pyrimidin-5-yl]acetate876668-00-7C16H14ClN3O3
- 3-(2,5-Dimethyl-7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)propanoic acid878417-25-5C17H17N3O3
- 5-(tert-Butyl)-3-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7-ol877800-82-3C17H18ClN3O
- 3-(3,4-Dimethoxyphenyl)-6-(2-hydroxyethyl)-5-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one866144-63-0C17H19N3O4
- Methyl 2-(2,5-dimethyl-7-oxo-3-phenyl-1H-pyrazolo[1,5-a]pyrimidin-6-yl)acetate890007-92-8C17H17N3O3
- 5-tert-Butyl-3-(2-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-ol902047-53-4C16H16ClN3O
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