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Murcko scaffold

1,5-Dihydro-1-phenyl-4H-pyrazolo(3,4-d)pyrimidin-4-one scaffold

286 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
286
With full pages
37
Scaffold SMILES

O=c1[nH]cnc2c1cnn2-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,5-Dihydro-1-phenyl-4H-pyrazolo(3,4-d)pyrimidin-4-one page
Murcko scaffold O=c1[nH]cnc2c1cnn2-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 286 chemicals

5-Amino-6-methylsulfanyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-one chemical structure, C12H11N5OS, CAS 500277-77-0
5-Amino-6-methylsulfanyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-one
CAS 500277-77-0C12H11N5OS
Ethyl 2-(4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetate chemical structure, C15H14N4O3, CAS 656831-55-9
Ethyl 2-(4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetate
CAS 656831-55-9C15H14N4O3
2-(4-Oxo-1-phenylpyrazolo[3,4-d]pyrimidin-5-yl)acetonitrile chemical structure, C13H9N5O, CAS 604754-49-6
2-(4-Oxo-1-phenylpyrazolo[3,4-d]pyrimidin-5-yl)acetonitrile
CAS 604754-49-6C13H9N5O
5-Amino-6-ethylsulfanyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-one chemical structure, C13H13N5OS, CAS 797765-40-3
5-Amino-6-ethylsulfanyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-one
CAS 797765-40-3C13H13N5OS
2-(1-(4-Fluorophenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide chemical structure, C13H10FN5O2, CAS 841211-23-2
2-(1-(4-Fluorophenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide
CAS 841211-23-2C13H10FN5O2
2-[1-(3,4-Dimethylphenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]acetamide chemical structure, C15H15N5O2, CAS 841211-83-4
2-[1-(3,4-Dimethylphenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]acetamide
CAS 841211-83-4C15H15N5O2
1,5-Dihydro-5-(2-oxopropyl)-1-phenyl-4H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C14H12N4O2, CAS 656831-68-4
1,5-Dihydro-5-(2-oxopropyl)-1-phenyl-4H-pyrazolo[3,4-d]pyrimidin-4-one
CAS 656831-68-4C14H12N4O2
2-[1-(4-Methylphenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]acetamide chemical structure, C14H13N5O2, CAS 841212-04-2
2-[1-(4-Methylphenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]acetamide
CAS 841212-04-2C14H13N5O2
5-Amino-1-phenyl-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C11H9N5O, CAS 69923-95-1
5-Amino-1-phenyl-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one
CAS 69923-95-1C11H9N5O
5-Amino-1-phenyl-6-prop-2-enylsulfanylpyrazolo[3,4-d]pyrimidin-4-one chemical structure, C14H13N5OS, CAS 4848-69-5
5-Amino-1-phenyl-6-prop-2-enylsulfanylpyrazolo[3,4-d]pyrimidin-4-one
CAS 4848-69-5C14H13N5OS
5-Amino-1-phenyl-6-propylsulfanylpyrazolo[3,4-d]pyrimidin-4-one chemical structure, C14H15N5OS, CAS 797769-66-5
5-Amino-1-phenyl-6-propylsulfanylpyrazolo[3,4-d]pyrimidin-4-one
CAS 797769-66-5C14H15N5OS
5-Amino-6-butylsulfanyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-one chemical structure, C15H17N5OS, CAS 692270-10-3
5-Amino-6-butylsulfanyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-one
CAS 692270-10-3C15H17N5OS
2-[1-(3-Chlorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]-N-methylacetamide chemical structure, C14H12ClN5O2, CAS 778623-11-3
2-[1-(3-Chlorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]-N-methylacetamide
CAS 778623-11-3C14H12ClN5O2
Ethyl 2-[[2-(4-oxo-1-phenylpyrazolo[3,4-d]pyrimidin-5-yl)acetyl]amino]acetate chemical structure, C17H17N5O4, CAS 852440-24-5
Ethyl 2-[[2-(4-oxo-1-phenylpyrazolo[3,4-d]pyrimidin-5-yl)acetyl]amino]acetate
CAS 852440-24-5C17H17N5O4
Ethyl 2-[[2-[1-(4-methylphenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]acetyl]amino]acetate chemical structure, C18H19N5O4, CAS 841212-23-5
Ethyl 2-[[2-[1-(4-methylphenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]acetyl]amino]acetate
CAS 841212-23-5C18H19N5O4
Ethyl 2-[1-(4-chlorophenyl)-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl]butanoate chemical structure, C17H17ClN4O3, CAS 852450-10-3
Ethyl 2-[1-(4-chlorophenyl)-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl]butanoate
CAS 852450-10-3C17H17ClN4O3
2-(1-(4-Fluorophenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetonitrile chemical structure, C13H8FN5O, CAS 863446-98-4
2-(1-(4-Fluorophenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetonitrile
CAS 863446-98-4C13H8FN5O
Methyl 2-(1-(4-fluorophenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetate chemical structure, C14H11FN4O3, CAS 852451-05-9
Methyl 2-(1-(4-fluorophenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetate
CAS 852451-05-9C14H11FN4O3
2-{4-Oxo-1-phenyl-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-5-yl}acetamide chemical structure, C13H11N5O2, CAS 852440-01-8
2-{4-Oxo-1-phenyl-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-5-yl}acetamide
CAS 852440-01-8C13H11N5O2
2-[1-(4-Chlorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]acetamide chemical structure, C13H10ClN5O2, CAS 852440-70-1
2-[1-(4-Chlorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]acetamide
CAS 852440-70-1C13H10ClN5O2
Ethyl 2-[[2-[1-(4-chlorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]acetyl]amino]acetate chemical structure, C17H16ClN5O4, CAS 852441-21-5
Ethyl 2-[[2-[1-(4-chlorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]acetyl]amino]acetate
CAS 852441-21-5C17H16ClN5O4
Ethyl 2-[[2-[1-(4-fluorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]acetyl]amino]acetate chemical structure, C17H16FN5O4, CAS 852450-70-5
Ethyl 2-[[2-[1-(4-fluorophenyl)-4-oxopyrazolo[3,4-d]pyrimidin-5-yl]acetyl]amino]acetate
CAS 852450-70-5C17H16FN5O4
Ethyl 2-(2-(1-(3,4-dimethylphenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamido)acetate chemical structure, C19H21N5O4, CAS 852451-67-3
Ethyl 2-(2-(1-(3,4-dimethylphenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamido)acetate
CAS 852451-67-3C19H21N5O4
5-Butyl-1-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C16H18N4O, CAS 912621-59-1
5-Butyl-1-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
CAS 912621-59-1C16H18N4O