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Murcko scaffold

Ring system with 3 rings and 25 atoms

35 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
35
With full pages
3
Scaffold SMILES

O=C(CNS(=O)(=O)c1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNS(=O)(=O)c1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

N-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-4-methoxy-N-methylbenzenesulfonamide chemical structure, C20H24FN3O4S, CAS 593264-48-3
N-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-4-methoxy-N-methylbenzenesulfonamide
CAS 593264-48-3C20H24FN3O4S
N-[2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl]-4-methoxy-N-methylbenzenesulfonamide chemical structure, C20H24ClN3O4S, CAS 593264-49-4
N-[2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl]-4-methoxy-N-methylbenzenesulfonamide
CAS 593264-49-4C20H24ClN3O4S
4-Methoxy-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-N-methylbenzenesulfonamide chemical structure, C21H27N3O5S, CAS 667874-55-7
4-Methoxy-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-N-methylbenzenesulfonamide
CAS 667874-55-7C21H27N3O5S
2,3,5,6-Tetramethyl-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]benzene-1-sulfonamide chemical structure, C22H29N3O3S, CAS 690246-14-1
2,3,5,6-Tetramethyl-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]benzene-1-sulfonamide
CAS 690246-14-1C22H29N3O3S
2,5-Dimethyl-N-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)benzenesulfonamide chemical structure, C20H25N3O3S, CAS 690246-05-0
2,5-Dimethyl-N-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)benzenesulfonamide
CAS 690246-05-0C20H25N3O3S
N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl}-N,4-dimethylbenzenesulfonamide chemical structure, C21H27N3O4S, CAS 428851-58-5
N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl}-N,4-dimethylbenzenesulfonamide
CAS 428851-58-5C21H27N3O4S
N-[2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl]-4-methylbenzenesulfonamide chemical structure, C19H22ClN3O3S, CAS 664318-46-1
N-[2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl]-4-methylbenzenesulfonamide
CAS 664318-46-1C19H22ClN3O3S
N-[2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl]-N,2,4,6-tetramethylbenzenesulfonamide chemical structure, C22H28ClN3O3S, CAS 665017-59-4
N-[2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl]-N,2,4,6-tetramethylbenzenesulfonamide
CAS 665017-59-4C22H28ClN3O3S
N-[2-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-N,2,4,6-tetramethylbenzenesulfonamide chemical structure, C23H31N3O4S, CAS 665017-60-7
N-[2-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-N,2,4,6-tetramethylbenzenesulfonamide
CAS 665017-60-7C23H31N3O4S
3,4-Dimethoxy-N-methyl-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]benzenesulfonamide chemical structure, C21H27N3O5S, CAS 665017-70-9
3,4-Dimethoxy-N-methyl-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]benzenesulfonamide
CAS 665017-70-9C21H27N3O5S
N-{2-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl}-N,4-dimethylbenzenesulfonamide chemical structure, C21H27N3O4S, CAS 434299-87-3
N-{2-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl}-N,4-dimethylbenzenesulfonamide
CAS 434299-87-3C21H27N3O4S
4-Chloro-N-[2-[4-(2-fluorophenyl)piperazin-1-yl]-2-oxoethyl]-N-methylbenzenesulfonamide chemical structure, C19H21ClFN3O3S, CAS 625413-28-7
4-Chloro-N-[2-[4-(2-fluorophenyl)piperazin-1-yl]-2-oxoethyl]-N-methylbenzenesulfonamide
CAS 625413-28-7C19H21ClFN3O3S
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-N,4-dimethylbenzenesulfonamide chemical structure, C20H24FN3O3S, CAS 431912-79-7
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-N,4-dimethylbenzenesulfonamide
CAS 431912-79-7C20H24FN3O3S
2,5-Dichloro-N-[2-[4-(2-fluorophenyl)piperazin-1-yl]-2-oxoethyl]-N-methylbenzenesulfonamide chemical structure, C19H20Cl2FN3O3S, CAS 593264-74-5
2,5-Dichloro-N-[2-[4-(2-fluorophenyl)piperazin-1-yl]-2-oxoethyl]-N-methylbenzenesulfonamide
CAS 593264-74-5C19H20Cl2FN3O3S
N-Methyl-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]benzenesulfonamide chemical structure, C19H23N3O3S, CAS 593262-22-7
N-Methyl-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]benzenesulfonamide
CAS 593262-22-7C19H23N3O3S
N-{2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl}-N,4-dimethylbenzenesulfonamide chemical structure, C20H24ClN3O3S, CAS 592467-71-5
N-{2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl}-N,4-dimethylbenzenesulfonamide
CAS 592467-71-5C20H24ClN3O3S
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-2,4,6-trimethylbenzenesulfonamide chemical structure, C21H26FN3O3S, CAS 693806-16-5
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-2,4,6-trimethylbenzenesulfonamide
CAS 693806-16-5C21H26FN3O3S
4-Methyl-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]benzenesulfonamide chemical structure, C19H23N3O3S, CAS 693806-28-9
4-Methyl-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]benzenesulfonamide
CAS 693806-28-9C19H23N3O3S
N-{2-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-2-oxoethyl}-4-methoxy-N-methylbenzenesulfonamide chemical structure, C21H26ClN3O4S, CAS 693820-64-3
N-{2-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-2-oxoethyl}-4-methoxy-N-methylbenzenesulfonamide
CAS 693820-64-3C21H26ClN3O4S
N-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl}-N,4-dimethylbenzenesulfonamide chemical structure, C20H24FN3O3S, CAS 431915-47-8
N-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl}-N,4-dimethylbenzenesulfonamide
CAS 431915-47-8C20H24FN3O3S
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]benzenesulfonamide chemical structure, C18H20FN3O3S, CAS 679829-74-4
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]benzenesulfonamide
CAS 679829-74-4C18H20FN3O3S
N-[2-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-2-oxoethyl]-N,2,4,6-tetramethylbenzenesulfonamide chemical structure, C23H30ClN3O3S, CAS 675862-33-6
N-[2-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-2-oxoethyl]-N,2,4,6-tetramethylbenzenesulfonamide
CAS 675862-33-6C23H30ClN3O3S
N-{2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl}-4-methoxy-N,3-dimethylbenzenesulfonamide chemical structure, C21H26ClN3O4S, CAS 717833-34-6
N-{2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl}-4-methoxy-N,3-dimethylbenzenesulfonamide
CAS 717833-34-6C21H26ClN3O4S
N-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzenesulfonamide chemical structure, C20H22F3N3O4S, CAS 690644-26-9
N-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzenesulfonamide
CAS 690644-26-9C20H22F3N3O4S