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Murcko scaffold

Ring system with 4 rings and 27 atoms

34 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
34
With full pages
22
Scaffold SMILES

O=C(C1=CC(=O)N(CCN2CCOCC2)C1c1ccccc1)c1ccco1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(CCN2CCOCC2)C1c1ccccc1)c1ccco1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

5-(3-(Allyloxy)phenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one chemical structure, C24H26N2O6, CAS 619273-08-4
5-(3-(Allyloxy)phenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one
CAS 619273-08-4C24H26N2O6
5-(3,4-Diethoxyphenyl)-3-hydroxy-4-[(5-methyl(2-furyl))carbonyl]-1-(2-morpholi n-4-ylethyl)-3-pyrrolin-2-one chemical structure, C26H32N2O7, CAS 620119-15-5
5-(3,4-Diethoxyphenyl)-3-hydroxy-4-[(5-methyl(2-furyl))carbonyl]-1-(2-morpholi n-4-ylethyl)-3-pyrrolin-2-one
CAS 620119-15-5C26H32N2O7
4-(2-Furylcarbonyl)-3-hydroxy-5-(3-methoxy-4-propoxyphenyl)-1-(2-morpholin-4-y lethyl)-3-pyrrolin-2-one chemical structure, C25H30N2O7, CAS 636990-50-6
4-(2-Furylcarbonyl)-3-hydroxy-5-(3-methoxy-4-propoxyphenyl)-1-(2-morpholin-4-y lethyl)-3-pyrrolin-2-one
CAS 636990-50-6C25H30N2O7
3-Hydroxy-5-(3-methoxy-4-propoxyphenyl)-4-(5-methyl-2-furoyl)-1-[2-(4-morpholinyl)ethyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C26H32N2O7, CAS 636991-90-7
3-Hydroxy-5-(3-methoxy-4-propoxyphenyl)-4-(5-methyl-2-furoyl)-1-[2-(4-morpholinyl)ethyl]-1,5-dihydro-2H-pyrrol-2-one
CAS 636991-90-7C26H32N2O7
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-4-[(5-methyl(2-furyl))carbonyl]-1-(2-mo rpholin-4-ylethyl)-3-pyrrolin-2-one chemical structure, C25H30N2O7, CAS 638135-47-4
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-4-[(5-methyl(2-furyl))carbonyl]-1-(2-mo rpholin-4-ylethyl)-3-pyrrolin-2-one
CAS 638135-47-4C25H30N2O7
5-(4-Fluorophenyl)-4-(2-furoyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H21FN2O5, CAS 378752-59-1
5-(4-Fluorophenyl)-4-(2-furoyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 378752-59-1C21H21FN2O5
2-(3-Bromophenyl)-3-(furan-2-carbonyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one chemical structure, C21H21BrN2O5, CAS 381699-28-1
2-(3-Bromophenyl)-3-(furan-2-carbonyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one
CAS 381699-28-1C21H21BrN2O5
2-(2,4-Dimethoxyphenyl)-3-(furan-2-carbonyl)-4-hydroxy-1-(2-morpholinoethyl)-2H-pyrrol-5-one chemical structure, C23H26N2O7, CAS 378214-42-7
2-(2,4-Dimethoxyphenyl)-3-(furan-2-carbonyl)-4-hydroxy-1-(2-morpholinoethyl)-2H-pyrrol-5-one
CAS 378214-42-7C23H26N2O7
4-(Furan-2-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one chemical structure, C21H21N3O7, CAS 380891-03-2
4-(Furan-2-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one
CAS 380891-03-2C21H21N3O7
2-(3,4-Dimethoxyphenyl)-3-(furan-2-carbonyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one chemical structure, C23H26N2O7, CAS 378768-64-0
2-(3,4-Dimethoxyphenyl)-3-(furan-2-carbonyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one
CAS 378768-64-0C23H26N2O7
4-(Furan-2-carbonyl)-3-hydroxy-5-(4-methoxyphenyl)-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one chemical structure, C22H24N2O6, CAS 380156-61-6
4-(Furan-2-carbonyl)-3-hydroxy-5-(4-methoxyphenyl)-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one
CAS 380156-61-6C22H24N2O6
5-(3,4-Dichlorophenyl)-4-(2-furylcarbonyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one chemical structure, C21H20Cl2N2O5, CAS 381694-06-0
5-(3,4-Dichlorophenyl)-4-(2-furylcarbonyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one
CAS 381694-06-0C21H20Cl2N2O5
4-(Furan-2-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one chemical structure, C21H21N3O7, CAS 381178-37-6
4-(Furan-2-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one
CAS 381178-37-6C21H21N3O7
5-(2-F-PH)-4-(2-Furoyl)-3-HO-1-(2-(4-morpholinyl)ET)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H21FN2O5, CAS 378207-19-3
5-(2-F-PH)-4-(2-Furoyl)-3-HO-1-(2-(4-morpholinyl)ET)-1,5-dihydro-2H-pyrrol-2-one
CAS 378207-19-3C21H21FN2O5
4-(Furan-2-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-5-phenyl-1H-pyrrol-2(5H)-one chemical structure, C21H22N2O5, CAS 381707-58-0
4-(Furan-2-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-5-phenyl-1H-pyrrol-2(5H)-one
CAS 381707-58-0C21H22N2O5
4-(Furan-2-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-5-(3,4,5-trimethoxyphenyl)-1H-pyrrol-2(5H)-one chemical structure, C24H28N2O8, CAS 384351-71-7
4-(Furan-2-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-5-(3,4,5-trimethoxyphenyl)-1H-pyrrol-2(5H)-one
CAS 384351-71-7C24H28N2O8
5-(2,3-Dimethoxyphenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one chemical structure, C24H28N2O7, CAS 433310-35-1
5-(2,3-Dimethoxyphenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one
CAS 433310-35-1C24H28N2O7
4-(Furan-2-carbonyl)-3-hydroxy-5-(3-methoxyphenyl)-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H24N2O6, CAS 459204-59-2
4-(Furan-2-carbonyl)-3-hydroxy-5-(3-methoxyphenyl)-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 459204-59-2C22H24N2O6
4-Hydroxy-2-(3-methoxyphenyl)-3-(5-methylfuran-2-carbonyl)-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one chemical structure, C23H26N2O6, CAS 371203-66-6
4-Hydroxy-2-(3-methoxyphenyl)-3-(5-methylfuran-2-carbonyl)-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one
CAS 371203-66-6C23H26N2O6
(4E)-5-(4-Ethoxyphenyl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]-1-[2-(morpholin-4-yl)ethyl]pyrrolidine-2,3-dione chemical structure, C24H28N2O6, CAS 369399-43-9
(4E)-5-(4-Ethoxyphenyl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]-1-[2-(morpholin-4-yl)ethyl]pyrrolidine-2,3-dione
CAS 369399-43-9C24H28N2O6
5-(4-Chlorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one chemical structure, C21H21ClN2O5, CAS 380880-10-4
5-(4-Chlorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one
CAS 380880-10-4C21H21ClN2O5
5-(2,5-Dimethoxyphenyl)-4-(2-furylcarbonyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one chemical structure, C23H26N2O7, CAS 503432-98-2
5-(2,5-Dimethoxyphenyl)-4-(2-furylcarbonyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one
CAS 503432-98-2C23H26N2O7
4-(Furan-2-carbonyl)-3-hydroxy-5-(4-isopropyl-phenyl)-1-(2-morpholin-4-yl-ethyl)-1,5-dihydro-pyrrol-2-one chemical structure, C24H28N2O5, CAS 380592-09-6
4-(Furan-2-carbonyl)-3-hydroxy-5-(4-isopropyl-phenyl)-1-(2-morpholin-4-yl-ethyl)-1,5-dihydro-pyrrol-2-one
CAS 380592-09-6C24H28N2O5
5-(3-Ethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H26N2O6, CAS 619274-40-7
5-(3-Ethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 619274-40-7C23H26N2O6