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Murcko scaffold

Ring system with 4 rings and 27 atoms

20 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 27
Chemicals: 20
With full pages: 5

Scaffold SMILES

O=C(C1=CC(=O)N(CCN2CCOCC2)C1c1ccccc1)c1cncs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C1=CC(=O)N(CCN2CCOCC2)C1c1ccccc1)c1cncs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

2-(2,3-Dimethoxyphenyl)-3-(2,4-dimethyl-1,3-thiazole-5-carbonyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one chemical structure, C24H29N3O6S, CAS 627821-75-4

2-(2,3-Dimethoxyphenyl)-3-(2,4-dimethyl-1,3-thiazole-5-carbonyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one

CAS 627821-75-4C₂₄H₂₉N₃O₆S

2-(2,5-Dimethoxyphenyl)-3-(2,4-dimethyl-1,3-thiazole-5-carbonyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one chemical structure, C24H29N3O6S, CAS 627821-81-2

2-(2,5-Dimethoxyphenyl)-3-(2,4-dimethyl-1,3-thiazole-5-carbonyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one

CAS 627821-81-2C₂₄H₂₉N₃O₆S

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-3-hydroxy-5-(2-methoxyphenyl)-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one chemical structure, C23H27N3O5S, CAS 627821-41-4

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-3-hydroxy-5-(2-methoxyphenyl)-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one

CAS 627821-41-4C₂₃H₂₇N₃O₅S

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-3-hydroxy-5-(4-methoxyphenyl)-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one chemical structure, C23H27N3O5S, CAS 627820-87-5

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-3-hydroxy-5-(4-methoxyphenyl)-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one

CAS 627820-87-5C₂₃H₂₇N₃O₅S

3-(2,4-Dimethyl-1,3-thiazole-5-carbonyl)-4-hydroxy-2-(3-methoxyphenyl)-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one chemical structure, C23H27N3O5S, CAS 5660-04-8

3-(2,4-Dimethyl-1,3-thiazole-5-carbonyl)-4-hydroxy-2-(3-methoxyphenyl)-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one

CAS 5660-04-8C₂₃H₂₇N₃O₅S

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-5-(4-fluorophenyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one chemical structure, C22H24FN3O4S, CAS 627820-24-0

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-5-(4-fluorophenyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one

CAS 627820-24-0C₂₂H₂₄FN₃O₄S

4-(2,4-Dimethylthiazole-5-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one chemical structure, C23H27N3O4S, CAS 627820-12-6

4-(2,4-Dimethylthiazole-5-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one

CAS 627820-12-6C₂₃H₂₇N₃O₄S

Methyl 4-{3-[(2,4-dimethyl(1,3-thiazol-5-yl))carbonyl]-4-hydroxy-1-(2-morpholi n-4-ylethyl)-5-oxo-3-pyrrolin-2-yl}benzoate chemical structure, C24H27N3O6S, CAS 627820-93-3

Methyl 4-{3-[(2,4-dimethyl(1,3-thiazol-5-yl))carbonyl]-4-hydroxy-1-(2-morpholi n-4-ylethyl)-5-oxo-3-pyrrolin-2-yl}benzoate

CAS 627820-93-3C₂₄H₂₇N₃O₆S

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-5-(3-bromophenyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one chemical structure, C22H24BrN3O4S, CAS 627820-18-2

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-5-(3-bromophenyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one

CAS 627820-18-2C₂₂H₂₄BrN₃O₄S

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-5-[4-(tert-butyl)phenyl]-3-hydrox y-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one chemical structure, C26H33N3O4S, CAS 627820-39-7

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-5-[4-(tert-butyl)phenyl]-3-hydrox y-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one

CAS 627820-39-7C₂₆H₃₃N₃O₄S

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-3-hydroxy-5-[4-(methylethyl)pheny l]-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one chemical structure, C25H31N3O4S, CAS 627821-38-9

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-3-hydroxy-5-[4-(methylethyl)pheny l]-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one

CAS 627821-38-9C₂₅H₃₁N₃O₄S

5-(3,4-Dimethoxyphenyl)-4-[(2,4-dimethyl(1,3-thiazol-5-yl))carbonyl]-3-hydroxy-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one chemical structure, C24H29N3O6S, CAS 627820-42-2

5-(3,4-Dimethoxyphenyl)-4-[(2,4-dimethyl(1,3-thiazol-5-yl))carbonyl]-3-hydroxy-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one

CAS 627820-42-2C₂₄H₂₉N₃O₆S

4-(2,4-Dimethylthiazole-5-carbonyl)-5-(3-fluorophenyl)-3-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one chemical structure, C22H24FN3O4S, CAS 638134-93-7

4-(2,4-Dimethylthiazole-5-carbonyl)-5-(3-fluorophenyl)-3-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one

CAS 638134-93-7C₂₂H₂₄FN₃O₄S

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-3-hydroxy-1-(2-morpholin-4-ylethy l)-5-(3,4,5-trimethoxyphenyl)-3-pyrrolin-2-one chemical structure, C25H31N3O7S, CAS 627820-57-9

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-3-hydroxy-1-(2-morpholin-4-ylethy l)-5-(3,4,5-trimethoxyphenyl)-3-pyrrolin-2-one

CAS 627820-57-9C₂₅H₃₁N₃O₇S

4-(2,4-Dimethylthiazole-5-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-5-phenyl-1H-pyrrol-2(5H)-one chemical structure, C22H25N3O4S, CAS 627820-06-8

4-(2,4-Dimethylthiazole-5-carbonyl)-3-hydroxy-1-(2-morpholinoethyl)-5-phenyl-1H-pyrrol-2(5H)-one

CAS 627820-06-8C₂₂H₂₅N₃O₄S

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-5-(4-bromophenyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one chemical structure, C22H24BrN3O4S, CAS 627820-27-3

4-[(2,4-Dimethyl(1,3-thiazol-5-yl))carbonyl]-5-(4-bromophenyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-3-pyrrolin-2-one

CAS 627820-27-3C₂₂H₂₄BrN₃O₄S

4-[(2,4-Dimethyl-1,3-thiazol-5-yl)carbonyl]-5-(4-ethoxyphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H29N3O5S, CAS 627820-36-4

4-[(2,4-Dimethyl-1,3-thiazol-5-yl)carbonyl]-5-(4-ethoxyphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-1,5-dihydro-2H-pyrrol-2-one

CAS 627820-36-4C₂₄H₂₉N₃O₅S

4-(2,4-Dimethylthiazole-5-carbonyl)-5-(2-fluorophenyl)-3-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one chemical structure, C22H24FN3O4S, CAS 627820-90-0

4-(2,4-Dimethylthiazole-5-carbonyl)-5-(2-fluorophenyl)-3-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one

CAS 627820-90-0C₂₂H₂₄FN₃O₄S

5-(4-Chlorophenyl)-4-[(2,4-dimethyl-1,3-thiazol-5-yl)carbonyl]-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H24ClN3O4S, CAS 627820-09-1

5-(4-Chlorophenyl)-4-[(2,4-dimethyl-1,3-thiazol-5-yl)carbonyl]-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-1,5-dihydro-2H-pyrrol-2-one

CAS 627820-09-1C₂₂H₂₄ClN₃O₄S

(E)-(2,4-Dimethyl-1,3-thiazol-5-yl){2-(3-methoxyphenyl)-1-[2-(morpholin-4-ium-4-yl)ethyl]-4,5-dioxopyrrolidin-3-ylidene}methanolate chemical structure, C23H27N3O5S

(E)-(2,4-Dimethyl-1,3-thiazol-5-yl){2-(3-methoxyphenyl)-1-[2-(morpholin-4-ium-4-yl)ethyl]-4,5-dioxopyrrolidin-3-ylidene}methanolate

C₂₃H₂₇N₃O₅S