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Murcko scaffold

Ring system with 4 rings and 27 atoms

23 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
23
With full pages
15
Scaffold SMILES

O=C(C1=CC(=O)N(CCN2CCOCC2)C1c1ccccc1)c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(CCN2CCOCC2)C1c1ccccc1)c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

3-Hydroxy-1-(2-morpholinoethyl)-4-(thiophene-2-carbonyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one chemical structure, C22H24N2O4S, CAS 381681-05-6
3-Hydroxy-1-(2-morpholinoethyl)-4-(thiophene-2-carbonyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one
CAS 381681-05-6C22H24N2O4S
5-(3-Bromophenyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-4-(thien-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H21BrN2O4S, CAS 378776-07-9
5-(3-Bromophenyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-4-(thien-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 378776-07-9C21H21BrN2O4S
5-(2-Fluorophenyl)-3-hydroxy-1-(2-(4-morpholinyl)ethyl)-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H21FN2O4S, CAS 381188-66-5
5-(2-Fluorophenyl)-3-hydroxy-1-(2-(4-morpholinyl)ethyl)-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 381188-66-5C21H21FN2O4S
3-Hydroxy-5-(4-isopropylphenyl)-1-(2-morpholinoethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C24H28N2O4S, CAS 378772-59-9
3-Hydroxy-5-(4-isopropylphenyl)-1-(2-morpholinoethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 378772-59-9C24H28N2O4S
3-Hydroxy-1-(2-morpholinoethyl)-5-(4-nitrophenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C21H21N3O6S, CAS 380868-40-6
3-Hydroxy-1-(2-morpholinoethyl)-5-(4-nitrophenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 380868-40-6C21H21N3O6S
3-Hydroxy-1-(2-morpholinoethyl)-5-(3-nitrophenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C21H21N3O6S, CAS 378762-40-4
3-Hydroxy-1-(2-morpholinoethyl)-5-(3-nitrophenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 378762-40-4C21H21N3O6S
3-Hydroxy-5-(4-methoxyphenyl)-1-(2-morpholinoethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C22H24N2O5S, CAS 380593-96-4
3-Hydroxy-5-(4-methoxyphenyl)-1-(2-morpholinoethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 380593-96-4C22H24N2O5S
2-(3,4-Dimethoxyphenyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C23H26N2O6S, CAS 381186-81-8
2-(3,4-Dimethoxyphenyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 381186-81-8C23H26N2O6S
3-Hydroxy-1-(2-morpholinoethyl)-5-phenyl-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C21H22N2O4S, CAS 380589-24-2
3-Hydroxy-1-(2-morpholinoethyl)-5-phenyl-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 380589-24-2C21H22N2O4S
2-(4-Chlorophenyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C21H21ClN2O4S, CAS 381197-13-3
2-(4-Chlorophenyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 381197-13-3C21H21ClN2O4S
5-(2,3-Dimethoxyphenyl)-3-hydroxy-1-(2-morpholinoethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C23H26N2O6S, CAS 385419-32-9
5-(2,3-Dimethoxyphenyl)-3-hydroxy-1-(2-morpholinoethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 385419-32-9C23H26N2O6S
3-Hydroxy-1-[2-(4-morpholinyl)ethyl]-4-(2-thienylcarbonyl)-5-(3,4,5-trimethoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H28N2O7S, CAS 433316-09-7
3-Hydroxy-1-[2-(4-morpholinyl)ethyl]-4-(2-thienylcarbonyl)-5-(3,4,5-trimethoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 433316-09-7C24H28N2O7S
(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-5-(3-methoxyphenyl)-1-[2-(morpholin-4-yl)ethyl]pyrrolidine-2,3-dione chemical structure, C22H24N2O5S, CAS 371923-53-4
(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-5-(3-methoxyphenyl)-1-[2-(morpholin-4-yl)ethyl]pyrrolidine-2,3-dione
CAS 371923-53-4C22H24N2O5S
(4E)-5-(4-Ethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-[2-(morpholin-4-yl)ethyl]pyrrolidine-2,3-dione chemical structure, C23H26N2O5S, CAS 384353-46-2
(4E)-5-(4-Ethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-[2-(morpholin-4-yl)ethyl]pyrrolidine-2,3-dione
CAS 384353-46-2C23H26N2O5S
5-(2,5-Dimethoxyphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H26N2O6S, CAS 503432-96-0
5-(2,5-Dimethoxyphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 503432-96-0C23H26N2O6S
5-(4-Butoxyphenyl)-3-hydroxy-1-[2-(4-morpholinyl)ethyl]-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H30N2O5S, CAS 618082-09-0
5-(4-Butoxyphenyl)-3-hydroxy-1-[2-(4-morpholinyl)ethyl]-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 618082-09-0C25H30N2O5S
5-(3-Ethoxyphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H26N2O5S, CAS 619271-45-3
5-(3-Ethoxyphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 619271-45-3C23H26N2O5S
3-Hydroxy-5-(3-methoxy-4-propoxyphenyl)-1-(2-morpholin-4-ylethyl)-4-(2-thienyl carbonyl)-3-pyrrolin-2-one chemical structure, C25H30N2O6S, CAS 636990-58-4
3-Hydroxy-5-(3-methoxy-4-propoxyphenyl)-1-(2-morpholin-4-ylethyl)-4-(2-thienyl carbonyl)-3-pyrrolin-2-one
CAS 636990-58-4C25H30N2O6S
3-Hydroxy-1-(2-morpholin-4-ylethyl)-5-(3-propoxyphenyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one chemical structure, C24H28N2O5S, CAS 620151-20-4
3-Hydroxy-1-(2-morpholin-4-ylethyl)-5-(3-propoxyphenyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one
CAS 620151-20-4C24H28N2O5S
3-Hydroxy-1-(2-morpholin-4-ylethyl)-5-(3-prop-2-enyloxyphenyl)-4-(2-thienylcar bonyl)-3-pyrrolin-2-one chemical structure, C24H26N2O5S, CAS 620151-88-4
3-Hydroxy-1-(2-morpholin-4-ylethyl)-5-(3-prop-2-enyloxyphenyl)-4-(2-thienylcar bonyl)-3-pyrrolin-2-one
CAS 620151-88-4C24H26N2O5S
5-(3,4-Diethoxyphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-4-(thiophene-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H30N2O6S, CAS 619273-81-3
5-(3,4-Diethoxyphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-4-(thiophene-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 619273-81-3C25H30N2O6S
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-4-(2-thienylc arbonyl)-3-pyrrolin-2-one chemical structure, C24H28N2O6S, CAS 636990-59-5
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-1-(2-morpholin-4-ylethyl)-4-(2-thienylc arbonyl)-3-pyrrolin-2-one
CAS 636990-59-5C24H28N2O6S
2-(4-{4-Hydroxy-1-[2-(morpholin-4-yl)ethyl]-5-oxo-3-(thiophen-2-ylcarbonyl)-2,5-dihydro-1H-pyrrol-2-yl}phenoxy)acetamide chemical structure, C23H25N3O6S, CAS 618079-59-7
2-(4-{4-Hydroxy-1-[2-(morpholin-4-yl)ethyl]-5-oxo-3-(thiophen-2-ylcarbonyl)-2,5-dihydro-1H-pyrrol-2-yl}phenoxy)acetamide
CAS 618079-59-7C23H25N3O6S