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Murcko scaffold

Ring system with 3 rings and 20 atoms

28 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
28
With full pages
3
Scaffold SMILES

c1ccc(OCc2cccc(-c3ccccc3)c2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(OCc2cccc(-c3ccccc3)c2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

3-{4-[(2'',6''-Dimethylbiphenyl-3-yl)methoxy]phenyl}propanoic Acid chemical structure, C24H24O3, CAS 691900-43-3
3-{4-[(2'',6''-Dimethylbiphenyl-3-yl)methoxy]phenyl}propanoic Acid
CAS 691900-43-3C24H24O3
AMG-837 sodium chemical structure, C26H20F3NaO3, CAS 865231-45-4
AMG-837 sodium
CAS 865231-45-4C26H20F3NaO3
Amg-837 chemical structure, C26H21F3O3, CAS 865231-46-5
Amg-837
CAS 865231-46-5C26H21F3O3
(3R)-3-[4-({3-[4-(Trifluoromethyl)phenyl]phenyl}methoxy)phenyl]hex-4-ynoic acid chemical structure, C26H21F3O3, CAS 865231-53-4
(3R)-3-[4-({3-[4-(Trifluoromethyl)phenyl]phenyl}methoxy)phenyl]hex-4-ynoic acid
CAS 865231-53-4C26H21F3O3
3-(4-([1,1'-Biphenyl]-3-ylmethoxy)phenyl)hex-4-ynoic acid chemical structure, C25H22O3, CAS 865231-50-1
3-(4-([1,1'-Biphenyl]-3-ylmethoxy)phenyl)hex-4-ynoic acid
CAS 865231-50-1C25H22O3
3-(4-{[4'-(2-Ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2-fluorophenyl)propanoic acid chemical structure, C28H31FO5, CAS 858096-92-1
3-(4-{[4'-(2-Ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2-fluorophenyl)propanoic acid
CAS 858096-92-1C28H31FO5
(R)-4-Hydroxy-6-(4-methoxyphenoxy)-4-methylhexanenitrile chemical structure, C26H21F3O3, CAS 1638744-77-0
(R)-4-Hydroxy-6-(4-methoxyphenoxy)-4-methylhexanenitrile
CAS 1638744-77-0C26H21F3O3
3-[(3-Methyl-4-nitrophenoxy)methyl]-4'-(trifluoromethyl)-1,1'-biphenyl chemical structure, C21H16F3NO3, CAS 648439-04-7
3-[(3-Methyl-4-nitrophenoxy)methyl]-4'-(trifluoromethyl)-1,1'-biphenyl
CAS 648439-04-7C21H16F3NO3
(S)-Methyl 4-(hydroxyimino)-3-(4-(3-(4-(trifluoromethyl)phenyl)benzyloxy)phenyl)butanoate chemical structure, C25H22F3NO4, CAS 1011531-93-3
(S)-Methyl 4-(hydroxyimino)-3-(4-(3-(4-(trifluoromethyl)phenyl)benzyloxy)phenyl)butanoate
CAS 1011531-93-3C25H22F3NO4
2-[2-[[3-[3-[(1~{S})-1-azanyl-2-oxidanyl-ethyl]phenyl]phenyl]methoxy]phenyl]ethanoic acid chemical structure, C23H23NO4, CAS 1646682-14-5
2-[2-[[3-[3-[(1~{S})-1-azanyl-2-oxidanyl-ethyl]phenyl]phenyl]methoxy]phenyl]ethanoic acid
CAS 1646682-14-5C23H23NO4
(2-{[3'-(Aminomethyl)-5'-methyl[1,1'-biphenyl]-3-yl]methoxy}phenyl)acetic acid chemical structure, C23H23NO3, CAS 1646570-06-0
(2-{[3'-(Aminomethyl)-5'-methyl[1,1'-biphenyl]-3-yl]methoxy}phenyl)acetic acid
CAS 1646570-06-0C23H23NO3
2,6-Dimethoxy-4-((2-methylbiphenyl-3-yl)methoxy)benzaldehyde chemical structure, C23H22O4, CAS 1675205-11-4
2,6-Dimethoxy-4-((2-methylbiphenyl-3-yl)methoxy)benzaldehyde
CAS 1675205-11-4C23H22O4
N-(2-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide chemical structure, C27H32N2O4, CAS 1675202-20-6
N-(2-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide
CAS 1675202-20-6C27H32N2O4
Orb1703675 chemical structure, C28H35NO4, CAS 1675204-51-9
Orb1703675
CAS 1675204-51-9C28H35NO4
AMG 837 hemicalcium salt chemical structure, C52H40CaF6O6, CAS 1291087-14-3
AMG 837 hemicalcium salt
CAS 1291087-14-3C52H40CaF6O6
FAA1 agonist-1 chemical structure, C21H17ClO5S, CAS 2102196-57-4
FAA1 agonist-1
CAS 2102196-57-4C21H17ClO5S
C52H46CaF6O8 chemical structure, C52H46CaF6O8
C52H46CaF6O8
C52H46CaF6O8
4-((2-Bromo-[1,1'-biphenyl]-3-yl)methoxy)-5-chloro-2-hydroxybenzaldehyde chemical structure, C20H14BrClO3, CAS 2156651-17-9
4-((2-Bromo-[1,1'-biphenyl]-3-yl)methoxy)-5-chloro-2-hydroxybenzaldehyde
CAS 2156651-17-9C20H14BrClO3
PD-1/PD-L1-IN-22 chemical structure, C25H26BrClN2O3, CAS 2159063-12-2
PD-1/PD-L1-IN-22
CAS 2159063-12-2C25H26BrClN2O3
PD-1-PDL1 Inhibitor C1a Hydrochloride chemical structure, C27H33ClN2O4, CAS 2108101-94-4
PD-1-PDL1 Inhibitor C1a Hydrochloride
CAS 2108101-94-4C27H33ClN2O4
5-Chloro-2-hydroxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]benzaldehyde chemical structure, C21H17ClO3, CAS 2278244-53-2
5-Chloro-2-hydroxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]benzaldehyde
CAS 2278244-53-2C21H17ClO3
AMG-837 Calcium Hydrate chemical structure, C52H42CaF6O7
AMG-837 Calcium Hydrate
C52H42CaF6O7
2-[2-Fluoro-4-[[3-(2-methylphenyl)phenyl]methoxy]phenoxy]acetic acid chemical structure, C22H19FO4, CAS 2378617-96-8
2-[2-Fluoro-4-[[3-(2-methylphenyl)phenyl]methoxy]phenoxy]acetic acid
CAS 2378617-96-8C22H19FO4
N-Hydroxy-6-[[3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methylamino]hexanamide chemical structure, C28H34N2O3, CAS 2364448-93-9
N-Hydroxy-6-[[3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methylamino]hexanamide
CAS 2364448-93-9C28H34N2O3