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Murcko scaffold

Ring system with 2 rings and 11 atoms

48 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
48
With full pages
3
Scaffold SMILES

c1cnn(Cc2cncs2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1cnn(Cc2cncs2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 48 chemicals

2-Chloro-5-(1H-pyrazol-1-ylmethyl)-1,3-thiazole chemical structure, C7H6ClN3S, CAS 453557-78-3
2-Chloro-5-(1H-pyrazol-1-ylmethyl)-1,3-thiazole
CAS 453557-78-3C7H6ClN3S
2-Chloro-5-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-1,3-thiazole chemical structure, C9H10ClN3S, CAS 477713-52-3
2-Chloro-5-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-1,3-thiazole
CAS 477713-52-3C9H10ClN3S
5-[(4-Bromo-1H-pyrazol-1-yl)methyl]-2-chloro-1,3-thiazole chemical structure, C7H5BrClN3S, CAS 1525598-55-3
5-[(4-Bromo-1H-pyrazol-1-yl)methyl]-2-chloro-1,3-thiazole
CAS 1525598-55-3C7H5BrClN3S
4-Amino-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazole-3-carboxylic acid chemical structure, C8H8N4O2S, CAS 1695106-82-1
4-Amino-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazole-3-carboxylic acid
CAS 1695106-82-1C8H8N4O2S
4-Amino-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazole-3-carboxamide chemical structure, C8H9N5OS, CAS 1702623-30-0
4-Amino-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazole-3-carboxamide
CAS 1702623-30-0C8H9N5OS
1-(1,3-Thiazol-5-ylmethyl)-1H-pyrazol-4-amine chemical structure, C7H8N4S, CAS 1566053-22-2
1-(1,3-Thiazol-5-ylmethyl)-1H-pyrazol-4-amine
CAS 1566053-22-2C7H8N4S
3,5-Dimethyl-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazol-4-amine chemical structure, C9H12N4S, CAS 1566455-28-4
3,5-Dimethyl-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazol-4-amine
CAS 1566455-28-4C9H12N4S
1-[(1,3-Thiazol-5-yl)methyl]-1H-pyrazol-3-amine chemical structure, C7H8N4S, CAS 1564597-80-3
1-[(1,3-Thiazol-5-yl)methyl]-1H-pyrazol-3-amine
CAS 1564597-80-3C7H8N4S
4-Bromo-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazol-3-amine chemical structure, C7H7BrN4S, CAS 1564858-29-2
4-Bromo-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazol-3-amine
CAS 1564858-29-2C7H7BrN4S
4-Chloro-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazol-3-amine chemical structure, C7H7ClN4S, CAS 1564814-52-3
4-Chloro-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazol-3-amine
CAS 1564814-52-3C7H7ClN4S
4-Methyl-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazol-3-amine chemical structure, C8H10N4S, CAS 1564637-54-2
4-Methyl-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazol-3-amine
CAS 1564637-54-2C8H10N4S
5-[(4-Bromo-1H-pyrazol-1-yl)methyl]-1,3-thiazole chemical structure, C7H6BrN3S, CAS 1565936-83-5
5-[(4-Bromo-1H-pyrazol-1-yl)methyl]-1,3-thiazole
CAS 1565936-83-5C7H6BrN3S
1-[(Dimethyl-1,3-thiazol-5-yl)methyl]-1H-pyrazol-4-amine chemical structure, C9H12N4S, CAS 2098049-47-7
1-[(Dimethyl-1,3-thiazol-5-yl)methyl]-1H-pyrazol-4-amine
CAS 2098049-47-7C9H12N4S
5-[(4-Bromo-1H-pyrazol-1-yl)methyl]-2,4-dimethyl-1,3-thiazole chemical structure, C9H10BrN3S, CAS 2098049-75-1
5-[(4-Bromo-1H-pyrazol-1-yl)methyl]-2,4-dimethyl-1,3-thiazole
CAS 2098049-75-1C9H10BrN3S
Methyl 5-((1H-pyrazol-1-yl)methyl)-2-bromothiazole-4-carboxylate chemical structure, C9H8BrN3O2S, CAS 1997284-03-3
Methyl 5-((1H-pyrazol-1-yl)methyl)-2-bromothiazole-4-carboxylate
CAS 1997284-03-3C9H8BrN3O2S
5-Methyl-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazol-3-amine chemical structure, C8H10N4S, CAS 1697760-30-7
5-Methyl-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazol-3-amine
CAS 1697760-30-7C8H10N4S
B-[1-(5-thiazolylmethyl)-1H-pyrazol-4-yl]boronic acid chemical structure, C7H8BN3O2S, CAS 1694668-09-1
B-[1-(5-thiazolylmethyl)-1H-pyrazol-4-yl]boronic acid
CAS 1694668-09-1C7H8BN3O2S
5-[(3,5-Dimethyl-1H-pyrazol-1-yl)methyl]-2,4-dimethyl-1,3-thiazole hydrochloride chemical structure, C11H16ClN3S, CAS 2320420-50-4
5-[(3,5-Dimethyl-1H-pyrazol-1-yl)methyl]-2,4-dimethyl-1,3-thiazole hydrochloride
CAS 2320420-50-4C11H16ClN3S
1-[(2-Chloro-5-thiazolyl)methyl]-1H-pyrazole-4-methanamine chemical structure, C8H9ClN4S, CAS 2167010-61-7
1-[(2-Chloro-5-thiazolyl)methyl]-1H-pyrazole-4-methanamine
CAS 2167010-61-7C8H9ClN4S
2,4-Dimethyl-5-[(1H-pyrazol-1-yl)methyl]-1,3-thiazole dihydrochloride chemical structure, C9H13Cl2N3S, CAS 2877634-34-7
2,4-Dimethyl-5-[(1H-pyrazol-1-yl)methyl]-1,3-thiazole dihydrochloride
CAS 2877634-34-7C9H13Cl2N3S
5-Methyl-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazol-4-amine chemical structure, C8H10N4S, CAS 2103986-91-8
5-Methyl-1-[(1,3-thiazol-5-yl)methyl]-1H-pyrazol-4-amine
CAS 2103986-91-8C8H10N4S
4-Methyl-1-[(2-methyl-1,3-thiazol-5-yl)methyl]-1H-pyrazol-3-amine chemical structure, C9H12N4S, CAS 2137555-62-3
4-Methyl-1-[(2-methyl-1,3-thiazol-5-yl)methyl]-1H-pyrazol-3-amine
CAS 2137555-62-3C9H12N4S
1-[(4-Chloro-1,3-thiazol-5-yl)methyl]-4-methyl-1H-pyrazol-3-amine chemical structure, C8H9ClN4S, CAS 2137552-20-4
1-[(4-Chloro-1,3-thiazol-5-yl)methyl]-4-methyl-1H-pyrazol-3-amine
CAS 2137552-20-4C8H9ClN4S
1-[(4-Chloro-1,3-thiazol-5-yl)methyl]-5-methyl-1H-pyrazol-4-amine chemical structure, C8H9ClN4S, CAS 2137554-55-1
1-[(4-Chloro-1,3-thiazol-5-yl)methyl]-5-methyl-1H-pyrazol-4-amine
CAS 2137554-55-1C8H9ClN4S