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Murcko scaffold

Ring system with 3 rings and 18 atoms

48 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
48
With full pages
1
Scaffold SMILES

O=C1COC(c2ccccc2)=C1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1COC(c2ccccc2)=C1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 48 chemicals

4-(2-Fluorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C19H17FO4S, CAS 301691-47-4
4-(2-Fluorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301691-47-4C19H17FO4S
4-(2,4-Difluorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C19H16F2O4S, CAS 301691-79-2
4-(2,4-Difluorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301691-79-2C19H16F2O4S
4-(4-Bromophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C19H17BrO4S, CAS 301691-73-6
4-(4-Bromophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301691-73-6C19H17BrO4S
4-(4-Fluorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C19H17FO4S, CAS 301691-32-7
4-(4-Fluorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301691-32-7C19H17FO4S
Polmacoxib chemical structure, C18H16FNO4S, CAS 301692-76-2
Polmacoxib
CAS 301692-76-2C18H16FNO4S
4-(3,4-Difluorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C19H16F2O4S, CAS 301691-77-0
4-(3,4-Difluorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301691-77-0C19H16F2O4S
4-(2,5-Difluorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C19H16F2O4S, CAS 301692-24-0
4-(2,5-Difluorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301692-24-0C19H16F2O4S
4-(2-Chlorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C19H17ClO4S, CAS 301691-55-4
4-(2-Chlorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301691-55-4C19H17ClO4S
4-(4-Chlorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C19H17ClO4S, CAS 301691-34-9
4-(4-Chlorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301691-34-9C19H17ClO4S
4-(3,5-Dichlorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C19H16Cl2O4S, CAS 301691-67-8
4-(3,5-Dichlorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301691-67-8C19H16Cl2O4S
2,2-Dimethyl-4-(3-fluorophenyl)-5-{4-(methylsulfonyl)phenyl}-3(2H)-furanone chemical structure, C19H17FO4S, CAS 301690-25-5
2,2-Dimethyl-4-(3-fluorophenyl)-5-{4-(methylsulfonyl)phenyl}-3(2H)-furanone
CAS 301690-25-5C19H17FO4S
4-(3-Chlorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C19H17ClO4S, CAS 301691-41-8
4-(3-Chlorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301691-41-8C19H17ClO4S
4-(2,4-Dichlorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C19H16Cl2O4S, CAS 301691-65-6
4-(2,4-Dichlorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301691-65-6C19H16Cl2O4S
4-(3,4-Dichlorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C19H16Cl2O4S, CAS 301691-37-2
4-(3,4-Dichlorophenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301691-37-2C19H16Cl2O4S
4-(5,5-Dimethyl-4-oxo-3-phenyl-4,5-dihydrofuran-2-yl)benzenesulfonamide chemical structure, C18H17NO4S, CAS 301692-84-2
4-(5,5-Dimethyl-4-oxo-3-phenyl-4,5-dihydrofuran-2-yl)benzenesulfonamide
CAS 301692-84-2C18H17NO4S
4-(3-Methoxyphenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one chemical structure, C20H20O5S, CAS 301692-07-9
4-(3-Methoxyphenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS 301692-07-9C20H20O5S
4-(3-(3-Chlorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide chemical structure, C18H16ClNO4S, CAS 301692-70-6
4-(3-(3-Chlorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide
CAS 301692-70-6C18H16ClNO4S
4-(3-(3,4-Difluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide chemical structure, C18H15F2NO4S, CAS 301692-94-4
4-(3-(3,4-Difluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide
CAS 301692-94-4C18H15F2NO4S
4-(3-(2,5-Difluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide chemical structure, C18H15F2NO4S, CAS 301693-32-3
4-(3-(2,5-Difluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide
CAS 301693-32-3C18H15F2NO4S
4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one chemical structure, C19H17FO2S, CAS 301693-50-5
4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one
CAS 301693-50-5C19H17FO2S
4-(3-(4-Fluoro-3-methoxyphenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide chemical structure, C19H18FNO5S, CAS 301693-22-1
4-(3-(4-Fluoro-3-methoxyphenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide
CAS 301693-22-1C19H18FNO5S
2,2-Dimethyl-5-(4-(methylthio)phenyl)-4-(4-nitrophenyl)furan-3(2H)-one chemical structure, C19H17NO4S, CAS 301693-58-3
2,2-Dimethyl-5-(4-(methylthio)phenyl)-4-(4-nitrophenyl)furan-3(2H)-one
CAS 301693-58-3C19H17NO4S
2,2-Dimethyl-5-{2-fluoro-4-(methylsulfonyl)phenyl}-4-phenyl-3(2H)-furanone chemical structure, C19H17FO4S, CAS 301695-67-0
2,2-Dimethyl-5-{2-fluoro-4-(methylsulfonyl)phenyl}-4-phenyl-3(2H)-furanone
CAS 301695-67-0C19H17FO4S
4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylsulfinyl)phenyl)furan-3(2H)-one chemical structure, C19H17FO3S, CAS 301693-70-9
4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylsulfinyl)phenyl)furan-3(2H)-one
CAS 301693-70-9C19H17FO3S