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Murcko scaffold

1-Benzyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one scaffold

23 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 23
With full pages: 2

Scaffold SMILES

O=C1CCNc2ccccc2N1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 1-Benzyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one page

Murcko scaffold O=C1CCNc2ccccc2N1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-5-acetyl-1-(phenylmethyl)- chemical structure, C18H18N2O2, CAS 105931-86-0

2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-5-acetyl-1-(phenylmethyl)-

CAS 105931-86-0C₁₈H₁₈N₂O₂

5-Acetyl-1-benzyl-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one chemical structure, C19H20N2O2, CAS 105931-87-1

5-Acetyl-1-benzyl-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one

CAS 105931-87-1C₁₉H₂₀N₂O₂

1-(4-Methylbenzyl)-8-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one chemical structure, C18H17F3N2O, CAS 866149-49-7

1-(4-Methylbenzyl)-8-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one

CAS 866149-49-7C₁₈H₁₇F₃N₂O

1-(4-Chlorobenzyl)-5-(methylsulfonyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one chemical structure, C17H17ClN2O3S, CAS 866138-34-3

1-(4-Chlorobenzyl)-5-(methylsulfonyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one

CAS 866138-34-3C₁₇H₁₇ClN₂O₃S

1-(4-Chlorobenzyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one chemical structure, C16H15ClN2O, CAS 866138-33-2

1-(4-Chlorobenzyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one

CAS 866138-33-2C₁₆H₁₅ClN₂O

5-Benzyl-3-methyl-4-oxo-2,3-dihydro-1,5-benzodiazepine-1-carbaldehyde chemical structure, C18H18N2O2, CAS 119483-60-2

5-Benzyl-3-methyl-4-oxo-2,3-dihydro-1,5-benzodiazepine-1-carbaldehyde

CAS 119483-60-2C₁₈H₁₈N₂O₂

5-(2-Chloro-6-fluorobenzyl)-3-methyl-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-carbaldehyde chemical structure, C18H16ClFN2O2, CAS 929839-16-7

5-(2-Chloro-6-fluorobenzyl)-3-methyl-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-carbaldehyde

CAS 929839-16-7C₁₈H₁₆ClFN₂O₂

1-Benzyl-4-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one chemical structure, C17H18N2O, CAS 174337-50-9

1-Benzyl-4-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

CAS 174337-50-9C₁₇H₁₈N₂O

1-(4-Bromobenzyl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one chemical structure, C17H17BrN2O, CAS 950353-63-6

1-(4-Bromobenzyl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one

CAS 950353-63-6C₁₇H₁₇BrN₂O

1-Benzyl-3-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one chemical structure, C17H18N2O, CAS 950398-51-3

1-Benzyl-3-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

CAS 950398-51-3C₁₇H₁₈N₂O

1-[(2-Chlorophenyl)methyl]-3-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one chemical structure, C17H17ClN2O, CAS 950306-57-7

1-[(2-Chlorophenyl)methyl]-3-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

CAS 950306-57-7C₁₇H₁₇ClN₂O

1-[(4-Chlorophenyl)methyl]-3-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one chemical structure, C17H17ClN2O, CAS 950398-58-0

1-[(4-Chlorophenyl)methyl]-3-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

CAS 950398-58-0C₁₇H₁₇ClN₂O

1-[(4-Fluorophenyl)methyl]-3-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one chemical structure, C17H17FN2O, CAS 950421-88-2

1-[(4-Fluorophenyl)methyl]-3-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

CAS 950421-88-2C₁₇H₁₇FN₂O

1-[(4-Bromophenyl)methyl]-3-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one chemical structure, C17H17BrN2O, CAS 950353-71-6

1-[(4-Bromophenyl)methyl]-3-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

CAS 950353-71-6C₁₇H₁₇BrN₂O

1-(2,6-Dichlorobenzyl)-3-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one chemical structure, C17H16Cl2N2O, CAS 950398-65-9

1-(2,6-Dichlorobenzyl)-3-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one

CAS 950398-65-9C₁₇H₁₆Cl₂N₂O

1-[(4-Fluorophenyl)methyl]-4-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one chemical structure, C17H17FN2O, CAS 950421-92-8

1-[(4-Fluorophenyl)methyl]-4-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

CAS 950421-92-8C₁₇H₁₇FN₂O

1-(2-Chloro-6-fluorobenzyl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one chemical structure, C17H16ClFN2O, CAS 950306-63-5

1-(2-Chloro-6-fluorobenzyl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one

CAS 950306-63-5C₁₇H₁₆ClFN₂O

1-(2,6-Dichlorobenzyl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one chemical structure, C17H16Cl2N2O, CAS 950398-72-8

1-(2,6-Dichlorobenzyl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one

CAS 950398-72-8C₁₇H₁₆Cl₂N₂O

1-[(2-Fluorophenyl)methyl]-4-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one chemical structure, C17H17FN2O, CAS 950421-96-2

1-[(2-Fluorophenyl)methyl]-4-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

CAS 950421-96-2C₁₇H₁₇FN₂O

4-Methyl-1-(2,3,5,6-tetramethylbenzyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one chemical structure, C21H26N2O, CAS 950353-79-4

4-Methyl-1-(2,3,5,6-tetramethylbenzyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one

CAS 950353-79-4C₂₁H₂₆N₂O

1-Benzyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one chemical structure, C16H16N2O, CAS 1333691-32-9

1-Benzyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

CAS 1333691-32-9C₁₆H₁₆N₂O

(S)-3-Amino-1-benzyl-8-fluoro-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C16H16FN3O, CAS 2407062-89-7

(S)-3-Amino-1-benzyl-8-fluoro-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one

CAS 2407062-89-7C₁₆H₁₆FN₃O

5-Benzyl-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-sulfonyl fluoride chemical structure, C16H15FN2O3S, CAS 2411306-65-3

5-Benzyl-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-sulfonyl fluoride

CAS 2411306-65-3C₁₆H₁₅FN₂O₃S