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Murcko scaffold

1-Benzyl-2-piperidone scaffold

120 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
120
With full pages
12
Scaffold SMILES

O=C1CCCCN1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzyl-2-piperidone page
Murcko scaffold O=C1CCCCN1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 120 chemicals

Methyl 1-(4-methoxybenzyl)-6-oxopiperidine-3-carboxylate chemical structure, C15H19NO4, CAS 1044561-59-2
Methyl 1-(4-methoxybenzyl)-6-oxopiperidine-3-carboxylate
CAS 1044561-59-2C15H19NO4
1-(3,4-Dimethoxybenzyl)-6-oxopiperidine-3-carboxylic acid chemical structure, C15H19NO5, CAS 1457094-68-6
1-(3,4-Dimethoxybenzyl)-6-oxopiperidine-3-carboxylic acid
CAS 1457094-68-6C15H19NO5
1-(2,4-Dimethoxybenzyl)-6-oxopiperidine-3-carboxylic Acid chemical structure, C15H19NO5, CAS 1356405-59-8
1-(2,4-Dimethoxybenzyl)-6-oxopiperidine-3-carboxylic Acid
CAS 1356405-59-8C15H19NO5
3-Amino-1-((3-(trifluoromethyl)phenyl)methyl)piperidin-2-one chemical structure, C13H15F3N2O, CAS 1404945-84-1
3-Amino-1-((3-(trifluoromethyl)phenyl)methyl)piperidin-2-one
CAS 1404945-84-1C13H15F3N2O
3-Amino-1-[1-(2-fluorophenyl)ethyl]piperidin-2-one chemical structure, C13H17FN2O, CAS 1404957-26-1
3-Amino-1-[1-(2-fluorophenyl)ethyl]piperidin-2-one
CAS 1404957-26-1C13H17FN2O
3-Amino-1-[1-(4-fluorophenyl)ethyl]piperidin-2-one chemical structure, C13H17FN2O, CAS 1404976-28-8
3-Amino-1-[1-(4-fluorophenyl)ethyl]piperidin-2-one
CAS 1404976-28-8C13H17FN2O
3-Amino-1-[(2,4-difluorophenyl)methyl]piperidin-2-one chemical structure, C12H14F2N2O, CAS 1404726-73-3
3-Amino-1-[(2,4-difluorophenyl)methyl]piperidin-2-one
CAS 1404726-73-3C12H14F2N2O
3-Bromo-1-{[3-(trifluoromethyl)phenyl]methyl}piperidin-2-one chemical structure, C13H13BrF3NO, CAS 1432678-90-4
3-Bromo-1-{[3-(trifluoromethyl)phenyl]methyl}piperidin-2-one
CAS 1432678-90-4C13H13BrF3NO
3-Bromo-1-[(2,4-difluorophenyl)methyl]piperidin-2-one chemical structure, C12H12BrF2NO, CAS 1408975-33-6
3-Bromo-1-[(2,4-difluorophenyl)methyl]piperidin-2-one
CAS 1408975-33-6C12H12BrF2NO
3-Amino-1-[(4-chlorophenyl)methyl]piperidin-2-one chemical structure, C12H15ClN2O, CAS 1344309-56-3
3-Amino-1-[(4-chlorophenyl)methyl]piperidin-2-one
CAS 1344309-56-3C12H15ClN2O
1-Benzyl-3-(methylamino)piperidin-2-one chemical structure, C13H18N2O, CAS 1341793-00-7
1-Benzyl-3-(methylamino)piperidin-2-one
CAS 1341793-00-7C13H18N2O
1-[(4-Fluorophenyl)methyl]-6-methyl-2-piperidinone chemical structure, C13H16FNO, CAS 870851-64-2
1-[(4-Fluorophenyl)methyl]-6-methyl-2-piperidinone
CAS 870851-64-2C13H16FNO
4-Amino-1-(2,4-dimethoxybenzyl)piperidin-2-one chemical structure, C14H20N2O3, CAS 1315495-75-0
4-Amino-1-(2,4-dimethoxybenzyl)piperidin-2-one
CAS 1315495-75-0C14H20N2O3
4-(Allylamino)-1-benzylpiperidin-2-one chemical structure, C15H20N2O, CAS 1315495-53-4
4-(Allylamino)-1-benzylpiperidin-2-one
CAS 1315495-53-4C15H20N2O
3-Amino-1-(2-fluoro-6-methoxybenzyl)piperidin-2-one chemical structure, C13H17FN2O2, CAS 1353255-16-9
3-Amino-1-(2-fluoro-6-methoxybenzyl)piperidin-2-one
CAS 1353255-16-9C13H17FN2O2
Ethyl 1-benzyl-2-oxopiperidine-3-carboxylate chemical structure, C15H19NO3, CAS 188885-08-7
Ethyl 1-benzyl-2-oxopiperidine-3-carboxylate
CAS 188885-08-7C15H19NO3
1-(2,4-Dimethoxybenzyl)-6-oxopiperidine-3-carboxylic Acid Methyl Ester chemical structure, C16H21NO5, CAS 1356405-58-7
1-(2,4-Dimethoxybenzyl)-6-oxopiperidine-3-carboxylic Acid Methyl Ester
CAS 1356405-58-7C16H21NO5
(S)-1-Benzyl-3-hydroxypiperidin-2-one chemical structure, C12H15NO2, CAS 1245644-72-7
(S)-1-Benzyl-3-hydroxypiperidin-2-one
CAS 1245644-72-7C12H15NO2
1-(4-Methoxybenzyl)-2-oxopiperidin-3-yl acetate chemical structure, C15H19NO4, CAS 1253790-65-6
1-(4-Methoxybenzyl)-2-oxopiperidin-3-yl acetate
CAS 1253790-65-6C15H19NO4
3-Hydroxy-1-(4-methoxybenzyl)piperidin-2-one chemical structure, C13H17NO3, CAS 1245644-82-9
3-Hydroxy-1-(4-methoxybenzyl)piperidin-2-one
CAS 1245644-82-9C13H17NO3
3-Iodo-1-(4-methoxybenzyl)piperidin-2-one chemical structure, C13H16INO2, CAS 1245646-02-9
3-Iodo-1-(4-methoxybenzyl)piperidin-2-one
CAS 1245646-02-9C13H16INO2
(3S)-2-Oxo-1-[(1R)-1-phenylethyl]piperidine-3-carboxylic acid chemical structure, C14H17NO3, CAS 845880-42-4
(3S)-2-Oxo-1-[(1R)-1-phenylethyl]piperidine-3-carboxylic acid
CAS 845880-42-4C14H17NO3
(3R,4S,5R)-1-Benzyl-2-oxopiperidine-3,4,5-triyl triacetate chemical structure, C18H21NO7, CAS 918949-31-2
(3R,4S,5R)-1-Benzyl-2-oxopiperidine-3,4,5-triyl triacetate
CAS 918949-31-2C18H21NO7
1-Benzyl-5-(aminomethyl)piperidin-2-one chemical structure, C13H18N2O, CAS 1272756-11-2
1-Benzyl-5-(aminomethyl)piperidin-2-one
CAS 1272756-11-2C13H18N2O