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Murcko scaffold

1-Benzyl-2-piperidone scaffold

120 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 14
Chemicals: 120
With full pages: 12

Scaffold SMILES

O=C1CCCCN1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 1-Benzyl-2-piperidone page

Murcko scaffold O=C1CCCCN1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 120 of 120 chemicals

1-[(3,4-Difluorophenyl)methyl]-2-oxopiperidine-3-carboxylic acid chemical structure, C13H13F2NO3, CAS 1326243-56-4

1-[(3,4-Difluorophenyl)methyl]-2-oxopiperidine-3-carboxylic acid

CAS 1326243-56-4C₁₃H₁₃F₂NO₃

1-Benzyl-5-methylpiperidin-2-one chemical structure, C13H17NO, CAS 1401845-61-1

1-Benzyl-5-methylpiperidin-2-one

CAS 1401845-61-1C₁₃H₁₇NO

tert-Butyl (S)-(1-benzyl-6-oxopiperidin-3-yl)carbamate chemical structure, C17H24N2O3, CAS 2173192-52-2

tert-Butyl (S)-(1-benzyl-6-oxopiperidin-3-yl)carbamate

CAS 2173192-52-2C₁₇H₂₄N₂O₃

N-(1-Benzyl-2-oxopiperidin-3-yl)but-2-ynamide chemical structure, C16H18N2O2, CAS 2411194-29-9

N-(1-Benzyl-2-oxopiperidin-3-yl)but-2-ynamide

CAS 2411194-29-9C₁₆H₁₈N₂O₂

2-Chloro-N-[1-[1-(2-fluorophenyl)ethyl]-2-oxopiperidin-3-yl]acetamide chemical structure, C15H18ClFN2O2, CAS 2411195-18-9

2-Chloro-N-[1-[1-(2-fluorophenyl)ethyl]-2-oxopiperidin-3-yl]acetamide

CAS 2411195-18-9C₁₅H₁₈ClFN₂O₂

(2E)-N-(1-Benzyl-2-oxopiperidin-3-yl)-4-(dimethylamino)but-2-enamide chemical structure, C18H25N3O2, CAS 2411327-43-8

(2E)-N-(1-Benzyl-2-oxopiperidin-3-yl)-4-(dimethylamino)but-2-enamide

CAS 2411327-43-8C₁₈H₂₅N₃O₂

N-(1-Benzyl-2-oxopiperidin-3-yl)-2-chloroacetamide chemical structure, C14H17ClN2O2, CAS 2411194-55-1

N-(1-Benzyl-2-oxopiperidin-3-yl)-2-chloroacetamide

CAS 2411194-55-1C₁₄H₁₇ClN₂O₂

N-(1-Benzyl-2-oxopiperidin-3-yl)prop-2-enamide chemical structure, C15H18N2O2, CAS 2411198-76-8

N-(1-Benzyl-2-oxopiperidin-3-yl)prop-2-enamide

CAS 2411198-76-8C₁₅H₁₈N₂O₂

N-Methyl-N-{[(2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)carbamoyl]methyl}prop-2-enamide chemical structure, C19H22F3N3O3, CAS 2197387-80-5

N-Methyl-N-{[(2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}piperidin-3-yl)carbamoyl]methyl}prop-2-enamide

CAS 2197387-80-5C₁₉H₂₂F₃N₃O₃

(R)-1-Benzyl-6-(hydroxymethyl)piperidin-2-one chemical structure, C13H17NO2, CAS 2489838-10-8

(R)-1-Benzyl-6-(hydroxymethyl)piperidin-2-one

CAS 2489838-10-8C₁₃H₁₇NO₂

1-Benzyl-6-(hydroxymethyl)piperidin-2-one chemical structure, C13H17NO2, CAS 2708286-97-7

1-Benzyl-6-(hydroxymethyl)piperidin-2-one

CAS 2708286-97-7C₁₃H₁₇NO₂

Methyl (R)-1-benzyl-6-oxopiperidine-2-carboxylate chemical structure, C14H17NO3, CAS 2489838-09-5

Methyl (R)-1-benzyl-6-oxopiperidine-2-carboxylate

CAS 2489838-09-5C₁₄H₁₇NO₃

(S)-1-Benzyl-6-(hydroxymethyl)piperidin-2-one chemical structure, C13H17NO2, CAS 2708341-33-5

(S)-1-Benzyl-6-(hydroxymethyl)piperidin-2-one

CAS 2708341-33-5C₁₃H₁₇NO₂

(R)-1-Benzyl-6-(((tert-butyldimethylsilyl)oxy)methyl)piperidin-2-one chemical structure, C19H31NO2Si, CAS 2489838-11-9

(R)-1-Benzyl-6-(((tert-butyldimethylsilyl)oxy)methyl)piperidin-2-one

CAS 2489838-11-9C₁₉H₃₁NO₂Si

Prop-2-en-1-yl (1-{[4-(aminomethyl)phenyl]methyl}-2-oxopiperidin-3-yl)carbamate chemical structure, C17H23N3O3, CAS 727374-88-1

Prop-2-en-1-yl (1-{[4-(aminomethyl)phenyl]methyl}-2-oxopiperidin-3-yl)carbamate

CAS 727374-88-1C₁₇H₂₃N₃O₃

Methyl 1-[(4-fluorophenyl)methyl]-6-oxopiperidine-2-carboxylate chemical structure, C14H16FNO3, CAS 2877628-25-4

Methyl 1-[(4-fluorophenyl)methyl]-6-oxopiperidine-2-carboxylate

CAS 2877628-25-4C₁₄H₁₆FNO₃

5-Amino-1-[(3-fluorophenyl)methyl]piperidin-2-one chemical structure, C12H15FN2O, CAS 2137559-40-9

5-Amino-1-[(3-fluorophenyl)methyl]piperidin-2-one

CAS 2137559-40-9C₁₂H₁₅FN₂O

5,5-Difluoro-1-[(4-methoxyphenyl)methyl]-6-oxo-2-(trifluoromethyl)piperidine-3-carboxylic acid chemical structure, C15H14F5NO4, CAS 2241140-18-9

5,5-Difluoro-1-[(4-methoxyphenyl)methyl]-6-oxo-2-(trifluoromethyl)piperidine-3-carboxylic acid

CAS 2241140-18-9C₁₅H₁₄F₅NO₄

1-[(4-Aminophenyl)methyl]piperidin-2-one dihydrochloride chemical structure, C12H18Cl2N2O, CAS 2551117-98-5

1-[(4-Aminophenyl)methyl]piperidin-2-one dihydrochloride

CAS 2551117-98-5C₁₂H₁₈Cl₂N₂O

4-Amino-1-benzylpiperidin-2-one dihydrochloride chemical structure, C12H18Cl2N2O, CAS 2763754-78-3

4-Amino-1-benzylpiperidin-2-one dihydrochloride

CAS 2763754-78-3C₁₂H₁₈Cl₂N₂O

N-(Butan-2-yl)-1-[(4-fluorophenyl)methyl]-6-oxopiperidine-2-carboxamide chemical structure, C17H23FN2O2, CAS 2770581-78-5

N-(Butan-2-yl)-1-[(4-fluorophenyl)methyl]-6-oxopiperidine-2-carboxamide

CAS 2770581-78-5C₁₇H₂₃FN₂O₂

1-[(4-Fluorophenyl)methyl]-6-oxo-N-(2,2,2-trifluoroethyl)piperidine-2-carboxamide chemical structure, C15H16F4N2O2, CAS 2770580-78-2

1-[(4-Fluorophenyl)methyl]-6-oxo-N-(2,2,2-trifluoroethyl)piperidine-2-carboxamide

CAS 2770580-78-2C₁₅H₁₆F₄N₂O₂

1-[(4-Fluorophenyl)methyl]-6-oxo-N-(prop-2-en-1-yl)piperidine-2-carboxamide chemical structure, C16H19FN2O2, CAS 2770579-65-0

1-[(4-Fluorophenyl)methyl]-6-oxo-N-(prop-2-en-1-yl)piperidine-2-carboxamide

CAS 2770579-65-0C₁₆H₁₉FN₂O₂

6-Allyl-1-benzylpiperidin-2-one chemical structure, C15H19NO, CAS 1854039-36-3

6-Allyl-1-benzylpiperidin-2-one

CAS 1854039-36-3C₁₅H₁₉NO