Murcko scaffold
6,7-Dihydro-2-benzothiophen-4(5H)-one scaffold
51 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 10
- Chemicals
- 51
- With full pages
- 7
Scaffold SMILES
O=C1CCCc2cscc21
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 51 chemicals
Isobenzothiophene-1-carboxylic acid, 4,5,6,7-tetrahydro-6,6-dimethyl-3-methylthio-4-oxo-, ethyl ester
CAS 168279-56-9C14H18O3S2
3-Methylsulfanyl-4-oxo-6,7-dihydro-5H-2-benzothiophene-1-carboxylic acid
CAS 168279-58-1C10H10O3S2
![Methyl 3-(ethylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate chemical structure, C14H18O3S2, CAS 172516-42-6](/s/DGCDOLUIZCGQES-UHFFFAOYSA-N.svg)
Methyl 3-(ethylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
CAS 172516-42-6C14H18O3S2
![Methyl 6,6-dimethyl-4-oxo-3-(propylthio)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate chemical structure, C15H20O3S2, CAS 175202-42-3](/s/JPDCVCSAGCKJIF-UHFFFAOYSA-N.svg)
Methyl 6,6-dimethyl-4-oxo-3-(propylthio)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
CAS 175202-42-3C15H20O3S2
![Ethyl 3-(isopropylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate chemical structure, C16H22O3S2, CAS 175202-44-5](/s/MKYKSCSPJSZFRF-UHFFFAOYSA-N.svg)
Ethyl 3-(isopropylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
CAS 175202-44-5C16H22O3S2
![Ethyl 3-(sec-butylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate chemical structure, C17H24O3S2, CAS 172516-44-8](/s/AMPIBRMRXUZXOA-UHFFFAOYSA-N.svg)
Ethyl 3-(sec-butylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
CAS 172516-44-8C17H24O3S2
![Ethyl 3-(Butylthio)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate chemical structure, C15H20O3S2, CAS 172516-33-5](/s/HCROBYJGELKPTO-UHFFFAOYSA-N.svg)
Ethyl 3-(Butylthio)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
CAS 172516-33-5C15H20O3S2
![Ethyl 3-(methylthio)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate chemical structure, C12H14O3S2, CAS 168279-54-7](/s/BHVLZDJJLSBOHJ-UHFFFAOYSA-N.svg)
Ethyl 3-(methylthio)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
CAS 168279-54-7C12H14O3S2
![Ethyl 3-[(2-ethoxy-2-oxoethyl)thio]-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate chemical structure, C15H18O5S2, CAS 172516-34-6](/s/XCOXOTJHYIPVBY-UHFFFAOYSA-N.svg)
Ethyl 3-[(2-ethoxy-2-oxoethyl)thio]-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
CAS 172516-34-6C15H18O5S2
![1-Acetyl-6,6-dimethyl-3-(methylthio)-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one chemical structure, C13H16O2S2, CAS 175202-49-0](/s/KQKPDZSWAQSYPD-UHFFFAOYSA-N.svg)
1-Acetyl-6,6-dimethyl-3-(methylthio)-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one
CAS 175202-49-0C13H16O2S2
6,6-Dimethyl-3-(methylthio)-4-oxo-4,5,6,7-tetrahydrobenzo(c)thiophene-1-carbonitrile
CAS 175202-50-3C12H13NOS2
3-(Methylthio)-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carbonitrile
CAS 168279-53-6C10H9NOS2
![Ethyl 6,6-dimethyl-3-(methylsulfonyl)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate chemical structure, C14H18O5S2, CAS 172516-46-0](/s/VWTILAZGQNBROA-UHFFFAOYSA-N.svg)
Ethyl 6,6-dimethyl-3-(methylsulfonyl)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
CAS 172516-46-0C14H18O5S2
![Ethyl 4-oxo-3-(propylthio)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate chemical structure, C14H18O3S2, CAS 172516-30-2](/s/LVWYWXLMDBCCKZ-UHFFFAOYSA-N.svg)
Ethyl 4-oxo-3-(propylthio)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
CAS 172516-30-2C14H18O3S2
![Ethyl 3-(ethylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate chemical structure, C15H20O3S2, CAS 172516-43-7](/s/JDZHCMKRPNLTTD-UHFFFAOYSA-N.svg)
Ethyl 3-(ethylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
CAS 172516-43-7C15H20O3S2
![Ethyl 3-(allylthio)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate chemical structure, C14H16O3S2, CAS 172516-32-4](/s/XJLCKTFJOYQKEL-UHFFFAOYSA-N.svg)
Ethyl 3-(allylthio)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
CAS 172516-32-4C14H16O3S2
![3-(Ethylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbonitrile chemical structure, C13H15NOS2, CAS 175202-70-7](/s/MBSBTZDYHQSAAV-UHFFFAOYSA-N.svg)
3-(Ethylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbonitrile
CAS 175202-70-7C13H15NOS2
![1-Chloro-6,6-dimethyl-3-(methylthio)-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one chemical structure, C11H13ClOS2, CAS 175202-90-1](/s/BXLYJKVZYWNDKK-UHFFFAOYSA-N.svg)
1-Chloro-6,6-dimethyl-3-(methylthio)-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one
CAS 175202-90-1C11H13ClOS2
Methyl 6,6-dimethyl-3-methylsulfanyl-4-oxo-5,7-dihydro-2-benzothiophene-1-carboxylate
CAS 882278-67-3C13H16O3S2
Sbb053495
CAS 172516-41-5C12H14O3S2
Ethyl 4,5,6,7-tetrahydro-3-((1-methylethyl)thio)-4-oxobenzo(c)thiophene-1-carboxylate
CAS 172516-31-3C14H18O3S2
6,6-Dimethyl-3-methylsulfanyl-5,7-dihydro-2-benzothiophen-4-one
CAS 172516-40-4C11H14OS2
1-Bromo-6,6-dimethyl-3-methylsulfanyl-5,7-dihydro-2-benzothiophen-4-one
CAS 207307-46-8C11H13BrOS2
6,6-Dimethyl-3-methylsulfonyl-5,7-dihydro-2-benzothiophen-4-one
CAS 882270-24-8C11H14O3S2
- 6,7-Dihydro-6,6-dimethyl-3-(methylsulfinyl)benzo[c]thiophen-4(5H)-one959583-96-1C11H14O2S2
- 1-Cyano-6,6-dimethyl-3-methanesulphonyl-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one207307-45-7C12H13NO3S2
- 1-Bromo-6,6-dimethyl-3-(methylsulfonyl)-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one410090-76-5C11H13BrO3S2
- 1-Bromo-3-methylsulfanyl-6,7-dihydro-5H-2-benzothiophen-4-one207307-53-7C9H9BrOS2
- 1-Bromo-3-methylsulfonyl-6,7-dihydro-5H-2-benzothiophen-4-one882271-53-6C9H9BrO3S2
- 3-(Methylthio)-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carbothioamide499771-14-1C10H11NOS3
- 1-Chloro-6,6-dimethyl-3-methylsulfonyl-5,7-dihydro-2-benzothiophen-4-one882288-28-0C11H13ClO3S2
- 1-Chloro-3-methylsulfinyl-6,7-dihydro-5H-2-benzothiophen-4-one957942-34-6C9H9ClO2S2
- Ethyl 3-cyano-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxobenzo[c]thiophene-1-carboxylate375846-30-3C14H15NO3S
- 3-(2-Hydroxyethylsulfanyl)-6,6-dimethyl-4-oxo-5,7-dihydro-2-benzothiophene-1-carbonitrile207307-49-1C13H15NO2S2
- 1-Chloro-6,6-dimethyl-3-methylsulfinyl-5,7-dihydro-2-benzothiophen-4-one959575-13-4C11H13ClO2S2
- 1,3-Dimethyl-6,7-dihydrobenzo[c]thiophen-4(5H)-one20892-17-5C10H12OS
- 6,6-Dimethyl-3-(methylsulfinyl)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbonitrile186371-17-5C12H13NO2S2
- 3-Ethoxycarbonylmethylsulfanyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid ethyl ester873189-06-1C17H22O5S2
- 1-Acetyl-3-(methylsulfanyl)-6,7-dihydro-2-benzothiophen-4(5H)-one168279-51-4C11H12O2S2
- 3-(Methylthio)-6,7-dihydrobenzo[c]thiophen-4(5H)-one168279-57-0C9H10OS2
- 6,6-Dimethyl-3-(methylthio)-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carbothioamide207307-82-2C12H15NOS3
- Ethyl 3-(methylsulfonyl)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate364757-81-3C12H14O5S2
- Ethyl 3-hydrazinyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carboxylate172516-47-1C13H18N2O3S
- 6,7-Dihydro-2-benzothiophen-4(5H)-one194471-55-1C8H8OS
- 1,3-Dichloro-4,5,6,7-tetrahydro-2-benzothiophen-4-one35061-13-3C8H6Cl2OS
- 6,6-Dimethyl-3-(methylsulfanyl)-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carbaldehyde1395919-77-3C12H14O2S2
- 6,6-Dimethyl-3-(methylsulfonyl)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid873189-09-4C12H14O5S2
- 5,5-Dimethyl-3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid ethyl ester910635-50-6C14H18O3S2
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