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Murcko scaffold

1-(4-Phenyl-1,3-thiazol-2-yl)piperazine scaffold

82 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
82
With full pages
6
Scaffold SMILES

c1ccc(-c2csc(N3CCNCC3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(4-Phenyl-1,3-thiazol-2-yl)piperazine page
Murcko scaffold c1ccc(-c2csc(N3CCNCC3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 82 of 82 chemicals

3-[2-(4-Methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzoic acid chemical structure, C15H17N3O2S, CAS 860344-60-1
3-[2-(4-Methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzoic acid
CAS 860344-60-1C15H17N3O2S
4-[5-Methyl-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzoic acid chemical structure, C16H19N3O2S, CAS 860344-50-9
4-[5-Methyl-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzoic acid
CAS 860344-50-9C16H19N3O2S
3-Fluoro-4-[2-(4-methylpiperazin-1-yl)-thiazol-4-yl]benzoic acid HCl salt chemical structure, C15H17ClFN3O2S, CAS 1059548-86-5
3-Fluoro-4-[2-(4-methylpiperazin-1-yl)-thiazol-4-yl]benzoic acid HCl salt
CAS 1059548-86-5C15H17ClFN3O2S
4-[2-(4-Methyl-1-piperazinyl)-4-thiazolyl]benzoic acid hydrobromide chemical structure, C15H18BrN3O2S, CAS 455253-69-7
4-[2-(4-Methyl-1-piperazinyl)-4-thiazolyl]benzoic acid hydrobromide
CAS 455253-69-7C15H18BrN3O2S
4-(5-Methyl-2-piperazin-1-yl-1,3-thiazol-4-yl)benzoic acid chemical structure, C15H17N3O2S, CAS 1059548-75-2
4-(5-Methyl-2-piperazin-1-yl-1,3-thiazol-4-yl)benzoic acid
CAS 1059548-75-2C15H17N3O2S
4-[5-Fluoro-2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzoic acid hydrochloride chemical structure, C15H17ClFN3O2S, CAS 1059549-28-8
4-[5-Fluoro-2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzoic acid hydrochloride
CAS 1059549-28-8C15H17ClFN3O2S
4-[5-Fluoro-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzoic acid, dihydrochloride chemical structure, C15H18Cl2FN3O2S, CAS 1094358-00-5
4-[5-Fluoro-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzoic acid, dihydrochloride
CAS 1094358-00-5C15H18Cl2FN3O2S
4-[5-Methyl-2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzoic acid hydrochloride chemical structure, C16H20ClN3O2S, CAS 1059549-04-0
4-[5-Methyl-2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzoic acid hydrochloride
CAS 1059549-04-0C16H20ClN3O2S
4-[2-(Piperazin-1-yl)-1,3-thiazol-4-yl]benzoic acid chemical structure, C14H15N3O2S, CAS 920009-73-0
4-[2-(Piperazin-1-yl)-1,3-thiazol-4-yl]benzoic acid
CAS 920009-73-0C14H15N3O2S
tert-Butyl 4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxylate chemical structure, C18H23N3O2S, CAS 887624-04-6
tert-Butyl 4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxylate
CAS 887624-04-6C18H23N3O2S
tert-Butyl 4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine-1-carboxylate chemical structure, C18H22FN3O2S, CAS 668484-33-1
tert-Butyl 4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine-1-carboxylate
CAS 668484-33-1C18H22FN3O2S
4-Phenyl-2-(piperazin-1-yl)thiazole hydrochloride chemical structure, C13H16ClN3S, CAS 1884156-02-8
4-Phenyl-2-(piperazin-1-yl)thiazole hydrochloride
CAS 1884156-02-8C13H16ClN3S
1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]piperazine trihydrate chemical structure, C13H20ClN3O3S, CAS 1984136-73-3
1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]piperazine trihydrate
CAS 1984136-73-3C13H20ClN3O3S
1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine trihydrate chemical structure, C13H20FN3O3S, CAS 1982950-26-4
1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine trihydrate
CAS 1982950-26-4C13H20FN3O3S
1-(5-Methyl-4-phenyl-1,3-thiazol-2-yl)piperazine hydrochloride chemical structure, C14H18ClN3S, CAS 2301849-67-0
1-(5-Methyl-4-phenyl-1,3-thiazol-2-yl)piperazine hydrochloride
CAS 2301849-67-0C14H18ClN3S
4-(4-Bromophenyl)-2-(4-(but-2-ynoyl)piperazin-1-yl)thiazole-5-carboxamide chemical structure, C18H17BrN4O2S, CAS 1628355-75-8
4-(4-Bromophenyl)-2-(4-(but-2-ynoyl)piperazin-1-yl)thiazole-5-carboxamide
CAS 1628355-75-8C18H17BrN4O2S
2-(4-(But-2-ynoyl)piperazin-1-yl)-4-(4-(methylsulfonyl)phenyl)thiazole-5-carboxamide chemical structure, C19H20N4O4S2, CAS 1628355-84-9
2-(4-(But-2-ynoyl)piperazin-1-yl)-4-(4-(methylsulfonyl)phenyl)thiazole-5-carboxamide
CAS 1628355-84-9C19H20N4O4S2
3-Fluoro-4-[2-(4-methyl-4-oxido-1-piperazinyl)-4-thiazolyl]benzoic acid methyl ester chemical structure, C16H18FN3O3S, CAS 1059549-35-7
3-Fluoro-4-[2-(4-methyl-4-oxido-1-piperazinyl)-4-thiazolyl]benzoic acid methyl ester
CAS 1059549-35-7C16H18FN3O3S
3-Fluoro-4-[2-(4-methyl-4-oxido-1-piperazinyl)-4-thiazolyl]benzoic acid chemical structure, C15H16FN3O3S, CAS 1059549-37-9
3-Fluoro-4-[2-(4-methyl-4-oxido-1-piperazinyl)-4-thiazolyl]benzoic acid
CAS 1059549-37-9C15H16FN3O3S
2-(4-Acryloylpiperazin-1-yl)-4-(4-bromophenyl)thiazole-5-carboxamide chemical structure, C17H17BrN4O2S, CAS 1628355-74-7
2-(4-Acryloylpiperazin-1-yl)-4-(4-bromophenyl)thiazole-5-carboxamide
CAS 1628355-74-7C17H17BrN4O2S
Ethyl 4-(4-bromophenyl)-2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-5-carboxylate chemical structure, C21H26BrN3O4S, CAS 1628356-02-4
Ethyl 4-(4-bromophenyl)-2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-5-carboxylate
CAS 1628356-02-4C21H26BrN3O4S
Methyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)-4-(4-(methylsulfonyl)phenyl)thiazole-5-carboxylate chemical structure, C21H27N3O6S2, CAS 1628356-16-0
Methyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)-4-(4-(methylsulfonyl)phenyl)thiazole-5-carboxylate
CAS 1628356-16-0C21H27N3O6S2
4-(2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-5-(methoxycarbonyl)thiazol-4-yl)benzoic acid chemical structure, C21H25N3O6S, CAS 1628356-17-1
4-(2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-5-(methoxycarbonyl)thiazol-4-yl)benzoic acid
CAS 1628356-17-1C21H25N3O6S
4-[5-(Aminocarbonyl)-4-(4-bromophenyl)-2-thiazolyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester chemical structure, C19H23BrN4O3S, CAS 1628356-35-3
4-[5-(Aminocarbonyl)-4-(4-bromophenyl)-2-thiazolyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
CAS 1628356-35-3C19H23BrN4O3S