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Murcko scaffold

1-(2-Pyrimidinyl)piperazine scaffold

599 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
599
With full pages
41
Scaffold SMILES

c1cnc(N2CCNCC2)nc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(2-Pyrimidinyl)piperazine page
Murcko scaffold c1cnc(N2CCNCC2)nc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 599 chemicals

1-(2-Pyrimidinyl)piperazine chemical structure, C8H12N4, CAS 20980-22-7
1-(2-Pyrimidinyl)piperazine
CAS 20980-22-7C8H12N4
RP 55462 chemical structure, C12H20ClN5, CAS 102396-29-2
RP 55462
CAS 102396-29-2C12H20ClN5
1-Piperazinebutanenitrile, 4-(2-pyrimidinyl)- chemical structure, C12H17N5, CAS 33386-14-0
1-Piperazinebutanenitrile, 4-(2-pyrimidinyl)-
CAS 33386-14-0C12H17N5
2,2,2-Trifluoro-1-(4-(pyrimidin-2-yl)piperazin-1-yl)ethan-1-one chemical structure, C10H11F3N4O, CAS 1549-78-6
2,2,2-Trifluoro-1-(4-(pyrimidin-2-yl)piperazin-1-yl)ethan-1-one
CAS 1549-78-6C10H11F3N4O
Ethyl 4-(pyrimidin-2-yl)piperazine-1-carboxylate chemical structure, C11H16N4O2, CAS 99931-83-6
Ethyl 4-(pyrimidin-2-yl)piperazine-1-carboxylate
CAS 99931-83-6C11H16N4O2
1-[4-Methyl-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]ethanone chemical structure, C12H18N4O, CAS 66373-34-0
1-[4-Methyl-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]ethanone
CAS 66373-34-0C12H18N4O
N-(Propan-2-yl)-4-(pyrimidin-2-yl)piperazine-1-carbothioamide chemical structure, C12H19N5S, CAS 452300-49-1
N-(Propan-2-yl)-4-(pyrimidin-2-yl)piperazine-1-carbothioamide
CAS 452300-49-1C12H19N5S
1-(5-Bromopyrimidin-2-yl)piperazine chemical structure, C8H11BrN4, CAS 99931-82-5
1-(5-Bromopyrimidin-2-yl)piperazine
CAS 99931-82-5C8H11BrN4
1-(4,6-Dimethyl-2-pyrimidyl)piperazine chemical structure, C10H16N4, CAS 22746-09-4
1-(4,6-Dimethyl-2-pyrimidyl)piperazine
CAS 22746-09-4C10H16N4
2-{4-[4-(Trifluoromethyl)pyrimidin-2-yl]piperazin-1-YL}ethanamine chemical structure, C11H16F3N5, CAS 683274-53-5
2-{4-[4-(Trifluoromethyl)pyrimidin-2-yl]piperazin-1-YL}ethanamine
CAS 683274-53-5C11H16F3N5
2-[4-(5-Bromopyrimidin-2-yl)piperazin-1-yl]ethanol chemical structure, C10H15BrN4O, CAS 849021-42-7
2-[4-(5-Bromopyrimidin-2-yl)piperazin-1-yl]ethanol
CAS 849021-42-7C10H15BrN4O
2-(Piperazin-1-yl)-4-(trifluoromethyl)pyrimidine chemical structure, C9H11F3N4, CAS 179756-91-3
2-(Piperazin-1-yl)-4-(trifluoromethyl)pyrimidine
CAS 179756-91-3C9H11F3N4
2-Chloro-1-{4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazino}ethan-1-one chemical structure, C11H12ClF3N4O, CAS 278791-54-1
2-Chloro-1-{4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazino}ethan-1-one
CAS 278791-54-1C11H12ClF3N4O
2-{4-[4-(Trifluoromethyl)pyrimidin-2-yl]piperazino}ethan-1-ol chemical structure, C11H15F3N4O, CAS 651004-99-8
2-{4-[4-(Trifluoromethyl)pyrimidin-2-yl]piperazino}ethan-1-ol
CAS 651004-99-8C11H15F3N4O
delta-Oxo-4-(2-pyrimidinyl)-1-piperazinepentanoic acid chemical structure, C13H18N4O3, CAS 209961-25-1
delta-Oxo-4-(2-pyrimidinyl)-1-piperazinepentanoic acid
CAS 209961-25-1C13H18N4O3
4-Oxo-4-[4-(pyrimidin-2-yl)piperazin-1-yl]butanoic acid chemical structure, C12H16N4O3, CAS 213186-60-8
4-Oxo-4-[4-(pyrimidin-2-yl)piperazin-1-yl]butanoic acid
CAS 213186-60-8C12H16N4O3
3,3-Dimethyl-5-oxo-5-(4-(pyrimidin-2-yl)piperazin-1-yl)pentanoic acid chemical structure, C15H22N4O3, CAS 717827-24-2
3,3-Dimethyl-5-oxo-5-(4-(pyrimidin-2-yl)piperazin-1-yl)pentanoic acid
CAS 717827-24-2C15H22N4O3
4-Amino-2-(4-methylpiperazin-1-yl)pyrimidine-5-carbonitrile chemical structure, C10H14N6, CAS 103151-40-2
4-Amino-2-(4-methylpiperazin-1-yl)pyrimidine-5-carbonitrile
CAS 103151-40-2C10H14N6
1-(2-Pyrimidyl)piperazine hydrochloride chemical structure, C8H13ClN4, CAS 78069-54-2
1-(2-Pyrimidyl)piperazine hydrochloride
CAS 78069-54-2C8H13ClN4
4-Pyrimidinamine, 5-bromo-6-chloro-N-(1-methylethyl)-2-(4-methyl-1-piperazinyl)-, monohydrochloride, hydrate chemical structure, C12H20BrCl2N5, CAS 61973-50-0
4-Pyrimidinamine, 5-bromo-6-chloro-N-(1-methylethyl)-2-(4-methyl-1-piperazinyl)-, monohydrochloride, hydrate
CAS 61973-50-0C12H20BrCl2N5
1-Piperazinecarboxamide, N-((dimethylamino)carbonyl)-N-methyl-4-(2-pyrimidinyl)- chemical structure, C13H20N6O2, CAS 80712-44-3
1-Piperazinecarboxamide, N-((dimethylamino)carbonyl)-N-methyl-4-(2-pyrimidinyl)-
CAS 80712-44-3C13H20N6O2
Piperazine, 1-(1,3-dioxobutyl)-4-(2-pyrimidinyl)- chemical structure, C12H16N4O2, CAS 164468-01-3
Piperazine, 1-(1,3-dioxobutyl)-4-(2-pyrimidinyl)-
CAS 164468-01-3C12H16N4O2
1-Piperazinepropanoic acid, beta-oxo-4-(2-pyrimidinyl)-, ethyl ester chemical structure, C13H18N4O3, CAS 164468-02-4
1-Piperazinepropanoic acid, beta-oxo-4-(2-pyrimidinyl)-, ethyl ester
CAS 164468-02-4C13H18N4O3
1-Piperazinepropanoic acid, beta-methyl-4-(2-pyrimidinyl)-, ethyl ester chemical structure, C14H22N4O2, CAS 164468-03-5
1-Piperazinepropanoic acid, beta-methyl-4-(2-pyrimidinyl)-, ethyl ester
CAS 164468-03-5C14H22N4O2