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Murcko scaffold

4-(Piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine scaffold

28 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
28
With full pages
3
Scaffold SMILES

c1nc(N2CCNCC2)c2cn[nH]c2n1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-(Piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine page
Murcko scaffold c1nc(N2CCNCC2)c2cn[nH]c2n1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

4-(Piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C9H12N6, CAS 853687-31-7
4-(Piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 853687-31-7C9H12N6
Ethyl 4-(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate chemical structure, C13H18N6O2, CAS 869072-37-7
Ethyl 4-(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate
CAS 869072-37-7C13H18N6O2
1-(1-Methyl-1H-pyrazolo(3,4-d)pyrimidin-4-yl)piperazine chemical structure, C10H14N6, CAS 245449-97-2
1-(1-Methyl-1H-pyrazolo(3,4-d)pyrimidin-4-yl)piperazine
CAS 245449-97-2C10H14N6
tert-Butyl 4-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate chemical structure, C14H20N6O2, CAS 245450-02-6
tert-Butyl 4-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate
CAS 245450-02-6C14H20N6O2
1-{1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}-4-(prop-2-yn-1-yl)piperazine chemical structure, C13H16N6, CAS 1281208-69-2
1-{1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}-4-(prop-2-yn-1-yl)piperazine
CAS 1281208-69-2C13H16N6
1-{1,6-Dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperazine chemical structure, C11H16N6, CAS 1092291-60-5
1-{1,6-Dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperazine
CAS 1092291-60-5C11H16N6
4-(4-Methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C10H14N6, CAS 1021206-72-3
4-(4-Methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 1021206-72-3C10H14N6
2-Chloro-1-(4-(1-methyl-1H-pyrazolo(3,4-d)pyrimidin-4-yl)piperazin-1-yl)ethan-1-one hydrochloride chemical structure, C12H16Cl2N6O, CAS 1258651-81-8
2-Chloro-1-(4-(1-methyl-1H-pyrazolo(3,4-d)pyrimidin-4-yl)piperazin-1-yl)ethan-1-one hydrochloride
CAS 1258651-81-8C12H16Cl2N6O
2-Chloro-1-(4-(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl)ethan-1-one chemical structure, C12H15ClN6O, CAS 1258826-89-9
2-Chloro-1-(4-(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl)ethan-1-one
CAS 1258826-89-9C12H15ClN6O
1-{1,6-Dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperazine dihydrochloride chemical structure, C11H18Cl2N6, CAS 1306603-02-0
1-{1,6-Dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperazine dihydrochloride
CAS 1306603-02-0C11H18Cl2N6
1-(1H-Pyrazolo(3,4-d)pyrimidin-4-yl)piperazine dihydrochloride chemical structure, C9H14Cl2N6, CAS 853680-94-1
1-(1H-Pyrazolo(3,4-d)pyrimidin-4-yl)piperazine dihydrochloride
CAS 853680-94-1C9H14Cl2N6
4-(2-Ethylpiperazin-1-yl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine chemical structure, C12H19N7, CAS 1802489-59-3
4-(2-Ethylpiperazin-1-yl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine
CAS 1802489-59-3C12H19N7
1-Methyl-4-(2-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine chemical structure, C11H17N7, CAS 1802489-62-8
1-Methyl-4-(2-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
CAS 1802489-62-8C11H17N7
tert-Butyl 4-(6-amino-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate chemical structure, C17H27N7O2, CAS 1802489-67-3
tert-Butyl 4-(6-amino-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate
CAS 1802489-67-3C17H27N7O2
1,3-Dimethyl-4-(2-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine chemical structure, C12H19N7, CAS 1802489-70-8
1,3-Dimethyl-4-(2-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
CAS 1802489-70-8C12H19N7
tert-Butyl (3S)-4-(6-amino-1-methylpyrazolo[5,4-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate chemical structure, C16H25N7O2, CAS 1616415-37-2
tert-Butyl (3S)-4-(6-amino-1-methylpyrazolo[5,4-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate
CAS 1616415-37-2C16H25N7O2
(S)-1,3-Dimethyl-4-(2-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine hydrochloride chemical structure, C12H20ClN7, CAS 1616415-41-8
(S)-1,3-Dimethyl-4-(2-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine hydrochloride
CAS 1616415-41-8C12H20ClN7
1-(4-{1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperazin-1-yl)prop-2-en-1-one chemical structure, C13H16N6O, CAS 2094213-71-3
1-(4-{1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperazin-1-yl)prop-2-en-1-one
CAS 2094213-71-3C13H16N6O
1-(4-{1,6-Dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperazin-1-yl)prop-2-en-1-one chemical structure, C14H18N6O, CAS 2094719-03-4
1-(4-{1,6-Dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperazin-1-yl)prop-2-en-1-one
CAS 2094719-03-4C14H18N6O
(S)-tert-Butyl 4-(6-amino-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate chemical structure, C17H27N7O2, CAS 1616415-40-7
(S)-tert-Butyl 4-(6-amino-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate
CAS 1616415-40-7C17H27N7O2
1-[1-(2-Chloroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-4-methylpiperazine chemical structure, C12H17ClN6, CAS 2097937-54-5
1-[1-(2-Chloroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-4-methylpiperazine
CAS 2097937-54-5C12H17ClN6
(S)-1-Methyl-4-(2-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine hydrochloride chemical structure, C11H18ClN7, CAS 1998701-02-2
(S)-1-Methyl-4-(2-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine hydrochloride
CAS 1998701-02-2C11H18ClN7
2-Chloro-1-[4-(1-methylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-one chemical structure, C13H17ClN6O, CAS 2411256-15-8
2-Chloro-1-[4-(1-methylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-one
CAS 2411256-15-8C13H17ClN6O
1-{1H-Pyrazolo[3,4-d]pyrimidin-4-yl}-4-(2,2,2-trifluoroethyl)piperazine chemical structure, C11H13F3N6, CAS 2741957-07-1
1-{1H-Pyrazolo[3,4-d]pyrimidin-4-yl}-4-(2,2,2-trifluoroethyl)piperazine
CAS 2741957-07-1C11H13F3N6