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Murcko scaffold

1-Phenyl-1H,2H,3H,4H-pyrrolo(1,2-a)pyrazine scaffold

59 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
59
With full pages
5
Scaffold SMILES

c1ccc(C2NCCn3cccc32)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-1H,2H,3H,4H-pyrrolo(1,2-a)pyrazine page
Murcko scaffold c1ccc(C2NCCn3cccc32)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 59 chemicals

1-(4-Chlorophenyl)-1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazine chemical structure, C13H13ClN2, CAS 112758-91-5
1-(4-Chlorophenyl)-1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazine
CAS 112758-91-5C13H13ClN2
1-Phenyl-1H,2H,3H,4H-pyrrolo(1,2-a)pyrazine chemical structure, C13H14N2, CAS 112758-89-1
1-Phenyl-1H,2H,3H,4H-pyrrolo(1,2-a)pyrazine
CAS 112758-89-1C13H14N2
1-(4-Fluorophenyl)-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine chemical structure, C13H13FN2, CAS 112767-38-1
1-(4-Fluorophenyl)-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine
CAS 112767-38-1C13H13FN2
1-(4-Methoxy-phenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine chemical structure, C14H16N2O, CAS 112758-90-4
1-(4-Methoxy-phenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine
CAS 112758-90-4C14H16N2O
1-(2-Fluorophenyl)-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine chemical structure, C13H13FN2, CAS 897615-91-7
1-(2-Fluorophenyl)-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine
CAS 897615-91-7C13H13FN2
1-(p-Tolyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C14H16N2, CAS 890090-95-6
1-(p-Tolyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 890090-95-6C14H16N2
1-(4-Ethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C15H18N2O, CAS 887201-27-6
1-(4-Ethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 887201-27-6C15H18N2O
1-(3,4-Dimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C15H18N2O2, CAS 887201-31-2
1-(3,4-Dimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 887201-31-2C15H18N2O2
1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C16H20N2O3, CAS 73627-27-7
1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 73627-27-7C16H20N2O3
N-Butyl-1-(2,5-dimethoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide chemical structure, C20H27N3O2S, CAS 393831-01-1
N-Butyl-1-(2,5-dimethoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide
CAS 393831-01-1C20H27N3O2S
N-Butyl-1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide chemical structure, C18H23N3S, CAS 393823-40-0
N-Butyl-1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide
CAS 393823-40-0C18H23N3S
N-Butyl-1-(2-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide chemical structure, C18H22FN3S, CAS 393824-79-8
N-Butyl-1-(2-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide
CAS 393824-79-8C18H22FN3S
N-(tert-Butyl)-1-(p-tolyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide chemical structure, C19H25N3S, CAS 393830-27-8
N-(tert-Butyl)-1-(p-tolyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide
CAS 393830-27-8C19H25N3S
N-(tert-Butyl)-1-(4-ethoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide chemical structure, C20H27N3O2, CAS 899960-60-2
N-(tert-Butyl)-1-(4-ethoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide
CAS 899960-60-2C20H27N3O2
N-Butyl-1-(4-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide chemical structure, C18H22ClN3S, CAS 393823-74-0
N-Butyl-1-(4-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide
CAS 393823-74-0C18H22ClN3S
N-Butyl-1-(4-fluorophenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carbothioamide chemical structure, C18H22FN3S, CAS 393824-11-8
N-Butyl-1-(4-fluorophenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carbothioamide
CAS 393824-11-8C18H22FN3S
N-Methyl-1-(p-tolyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide chemical structure, C16H19N3S, CAS 393830-24-5
N-Methyl-1-(p-tolyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide
CAS 393830-24-5C16H19N3S
1-(2,4-Dichlorophenyl)-N-methyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carbothioamide chemical structure, C15H15Cl2N3S, CAS 393825-20-2
1-(2,4-Dichlorophenyl)-N-methyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carbothioamide
CAS 393825-20-2C15H15Cl2N3S
N-Butyl-1-(p-tolyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide chemical structure, C19H25N3S, CAS 393830-26-7
N-Butyl-1-(p-tolyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide
CAS 393830-26-7C19H25N3S
N-Methyl-1-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide chemical structure, C18H23N3O3S, CAS 393833-43-7
N-Methyl-1-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide
CAS 393833-43-7C18H23N3O3S
N-Butyl-1-(4-nitrophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide chemical structure, C18H22N4O2S, CAS 393825-59-7
N-Butyl-1-(4-nitrophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide
CAS 393825-59-7C18H22N4O2S
N-Ethyl-1-(3-nitrophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide chemical structure, C16H18N4O2S, CAS 393830-59-6
N-Ethyl-1-(3-nitrophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carbothioamide
CAS 393830-59-6C16H18N4O2S
1-(2,4-Dichlorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C13H12Cl2N2, CAS 1024471-90-6
1-(2,4-Dichlorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 1024471-90-6C13H12Cl2N2
(S)-N-(2-(1-(2,4-Difluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethyl)propionamide chemical structure, C18H19F2N3O2, CAS 1004949-44-3
(S)-N-(2-(1-(2,4-Difluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethyl)propionamide
CAS 1004949-44-3C18H19F2N3O2