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Murcko scaffold

Ring system with 3 rings and 15 atoms

157 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 15
Chemicals: 157
With full pages: 69

Scaffold SMILES

C1=CC(c2ccccc2)c2c[nH]nc2O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold C1=CC(c2ccccc2)c2c[nH]nc2O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 157 chemicals

6-Amino-3-methyl-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C14H12N4O, CAS 81000-11-5

6-Amino-3-methyl-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 81000-11-5C₁₄H₁₂N₄O

6-Amino-4-(3-fluorophenyl)-1,4-dihydro-3-methylpyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C14H11FN4O, CAS 89607-36-3

6-Amino-4-(3-fluorophenyl)-1,4-dihydro-3-methylpyrano[2,3-c]pyrazole-5-carbonitrile

CAS 89607-36-3C₁₄H₁₁FN₄O

6-Amino-4-(3,4-dichlorophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C14H10Cl2N4O, CAS 315244-85-0

6-Amino-4-(3,4-dichlorophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 315244-85-0C₁₄H₁₀Cl₂N₄O

6-Amino-4-(4-bromophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C14H11BrN4O, CAS 89607-40-9

6-Amino-4-(4-bromophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 89607-40-9C₁₄H₁₁BrN₄O

6-Amino-4-(2-fluorophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C14H11FN4O, CAS 89607-35-2

6-Amino-4-(2-fluorophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 89607-35-2C₁₄H₁₁FN₄O

6-Amino-4-(4-fluorophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C14H11FN4O, CAS 89607-37-4

6-Amino-4-(4-fluorophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 89607-37-4C₁₄H₁₁FN₄O

6-Amino-4-(2-methoxyphenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C15H14N4O2, CAS 89700-76-5

6-Amino-4-(2-methoxyphenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 89700-76-5C₁₅H₁₄N₄O₂

6-Amino-3-methyl-4-(2,4,5-trimethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C17H18N4O4, CAS 302788-93-8

6-Amino-3-methyl-4-(2,4,5-trimethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 302788-93-8C₁₇H₁₈N₄O₄

6-Amino-4-(4-bromo-2-fluorophenyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C14H10BrFN4O, CAS 353463-73-7

6-Amino-4-(4-bromo-2-fluorophenyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 353463-73-7C₁₄H₁₀BrFN₄O

6-Amino-4-phenyl-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C16H16N4O, CAS 300393-93-5

6-Amino-4-phenyl-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 300393-93-5C₁₆H₁₆N₄O

6-Amino-4-(2-chlorophenyl)-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C16H15ClN4O, CAS 330158-68-4

6-Amino-4-(2-chlorophenyl)-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 330158-68-4C₁₆H₁₅ClN₄O

6-Amino-3-tert-butyl-4-(2,3-dimethoxyphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C19H22N4O3, CAS 298687-62-4

6-Amino-3-tert-butyl-4-(2,3-dimethoxyphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 298687-62-4C₁₉H₂₂N₄O₃

6-Amino-4-(2-chlorophenyl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C15H13ClN4O2, CAS 797028-44-5

6-Amino-4-(2-chlorophenyl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 797028-44-5C₁₅H₁₃ClN₄O₂

6-Amino-4-(4-hydroxy-3,5-dimethoxyphenyl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C17H18N4O5, CAS 664999-80-8

6-Amino-4-(4-hydroxy-3,5-dimethoxyphenyl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 664999-80-8C₁₇H₁₈N₄O₅

6-Amino-3-(methoxymethyl)-4-(2-methoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C16H16N4O3, CAS 300392-53-4

6-Amino-3-(methoxymethyl)-4-(2-methoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 300392-53-4C₁₆H₁₆N₄O₃

6-Amino-4-(2-fluorophenyl)-3-(methoxymethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C15H13FN4O2, CAS 401624-92-8

6-Amino-4-(2-fluorophenyl)-3-(methoxymethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 401624-92-8C₁₅H₁₃FN₄O₂

6-Amino-4-(3,5-dimethoxyphenyl)-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C18H20N4O3, CAS 371209-33-5

6-Amino-4-(3,5-dimethoxyphenyl)-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 371209-33-5C₁₈H₂₀N₄O₃

6-Amino-3-methyl-4-(4-methylphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C15H14N4O, CAS 82805-71-8

6-Amino-3-methyl-4-(4-methylphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 82805-71-8C₁₅H₁₄N₄O

6-Amino-4-(4-chlorophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C14H11ClN4O, CAS 89607-39-6

6-Amino-4-(4-chlorophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 89607-39-6C₁₄H₁₁ClN₄O

6-Amino-4-(2-chloro-6-fluorophenyl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C15H12ClFN4O2, CAS 317840-31-6

6-Amino-4-(2-chloro-6-fluorophenyl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 317840-31-6C₁₅H₁₂ClFN₄O₂

6-Amino-3-tert-butyl-4-(2-fluoro-5-methoxyphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C18H19FN4O2, CAS 354554-80-6

6-Amino-3-tert-butyl-4-(2-fluoro-5-methoxyphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 354554-80-6C₁₈H₁₉FN₄O₂

6-Amino-3-(methoxymethyl)-4-(3-methoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C16H16N4O3, CAS 370873-05-5

6-Amino-3-(methoxymethyl)-4-(3-methoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 370873-05-5C₁₆H₁₆N₄O₃

Ethyl [6-amino-5-cyano-4-(2,5-dimethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazol-3-yl]acetate chemical structure, C19H20N4O5, CAS 488802-88-6

Ethyl [6-amino-5-cyano-4-(2,5-dimethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazol-3-yl]acetate

CAS 488802-88-6C₁₉H₂₀N₄O₅

(4S)-6-Amino-3-methyl-4-(2-nitrophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C14H11N5O3, CAS 302778-35-4

(4S)-6-Amino-3-methyl-4-(2-nitrophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 302778-35-4C₁₄H₁₁N₅O₃