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Murcko scaffold

Ring system with 3 rings and 16 atoms

24 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
24
With full pages
7
Scaffold SMILES

O=c1oc2c(-c3ccccc3)cccc2s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1oc2c(-c3ccccc3)cccc2s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

5-Hydroxy-7-[3-(trifluoromethyl)phenyl]-1,3-benzoxathiol-2-one chemical structure, C14H7F3O3S, CAS 405921-10-0
5-Hydroxy-7-[3-(trifluoromethyl)phenyl]-1,3-benzoxathiol-2-one
CAS 405921-10-0C14H7F3O3S
7-(2,4-Dichlorophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one chemical structure, C13H6Cl2O3S, CAS 327078-58-0
7-(2,4-Dichlorophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one
CAS 327078-58-0C13H6Cl2O3S
7-(4-Fluorophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one chemical structure, C13H7FO3S, CAS 327078-62-6
7-(4-Fluorophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one
CAS 327078-62-6C13H7FO3S
7-(2,5-Dichlorophenyl)-5-hydroxy-1,3-benzoxathiol-2-one chemical structure, C13H6Cl2O3S, CAS 315240-92-7
7-(2,5-Dichlorophenyl)-5-hydroxy-1,3-benzoxathiol-2-one
CAS 315240-92-7C13H6Cl2O3S
7-(3,5-Dichlorophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one chemical structure, C13H6Cl2O3S, CAS 315240-93-8
7-(3,5-Dichlorophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one
CAS 315240-93-8C13H6Cl2O3S
5-Hydroxy-7-(4-methoxyphenyl)-1,3-benzoxathiol-2-one chemical structure, C14H10O4S, CAS 301681-86-7
5-Hydroxy-7-(4-methoxyphenyl)-1,3-benzoxathiol-2-one
CAS 301681-86-7C14H10O4S
7-(3-Chloro-4-methylphenyl)-5-hydroxy-1,3-benzoxathiol-2-one chemical structure, C14H9ClO3S, CAS 501349-52-6
7-(3-Chloro-4-methylphenyl)-5-hydroxy-1,3-benzoxathiol-2-one
CAS 501349-52-6C14H9ClO3S
7-(3-Chlorophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one chemical structure, C13H7ClO3S, CAS 307514-06-3
7-(3-Chlorophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one
CAS 307514-06-3C13H7ClO3S
5-Hydroxy-7-(4-methylphenyl)-2H-1,3-benzoxathiol-2-one chemical structure, C14H10O3S, CAS 327078-57-9
5-Hydroxy-7-(4-methylphenyl)-2H-1,3-benzoxathiol-2-one
CAS 327078-57-9C14H10O3S
7-(4-Chloro-phenyl)-5-hydroxy-benzo[1,3]oxathiol-2-one chemical structure, C13H7ClO3S, CAS 327078-55-7
7-(4-Chloro-phenyl)-5-hydroxy-benzo[1,3]oxathiol-2-one
CAS 327078-55-7C13H7ClO3S
7-(4-Bromophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one chemical structure, C13H7BrO3S, CAS 327078-63-7
7-(4-Bromophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one
CAS 327078-63-7C13H7BrO3S
5-Hydroxy-7-(4-nitrophenyl)-1,3-benzoxathiol-2-one chemical structure, C13H7NO5S, CAS 417701-01-0
5-Hydroxy-7-(4-nitrophenyl)-1,3-benzoxathiol-2-one
CAS 417701-01-0C13H7NO5S
7-(4-Ethoxyphenyl)-5-hydroxy-1,3-benzoxathiol-2-one chemical structure, C15H12O4S, CAS 638143-18-7
7-(4-Ethoxyphenyl)-5-hydroxy-1,3-benzoxathiol-2-one
CAS 638143-18-7C15H12O4S
2-Oxo-7-(3-(trifluoromethyl)phenyl)benzo[d][1,3]oxathiol-5-yl acetate chemical structure, C16H9F3O4S, CAS 325817-44-5
2-Oxo-7-(3-(trifluoromethyl)phenyl)benzo[d][1,3]oxathiol-5-yl acetate
CAS 325817-44-5C16H9F3O4S
5-Hydroxy-7-(4-iodophenyl)-1,3-benzoxathiol-2-one chemical structure, C13H7IO3S, CAS 638143-22-3
5-Hydroxy-7-(4-iodophenyl)-1,3-benzoxathiol-2-one
CAS 638143-22-3C13H7IO3S
7-(3-Fluorophenyl)-5-hydroxybenzo[d][1,3]oxathiol-2-one chemical structure, C13H7FO3S, CAS 868213-18-7
7-(3-Fluorophenyl)-5-hydroxybenzo[d][1,3]oxathiol-2-one
CAS 868213-18-7C13H7FO3S
5-Hydroxy-7-phenyl-1,3-benzoxathiol-2-one chemical structure, C13H8O3S, CAS 7735-67-3
5-Hydroxy-7-phenyl-1,3-benzoxathiol-2-one
CAS 7735-67-3C13H8O3S
7-(2-Chlorophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one chemical structure, C13H7ClO3S, CAS 301681-73-2
7-(2-Chlorophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one
CAS 301681-73-2C13H7ClO3S
7-(3,4-Dimethylphenyl)-5-hydroxy-1,3-benzoxathiol-2-one chemical structure, C15H12O3S, CAS 627889-77-4
7-(3,4-Dimethylphenyl)-5-hydroxy-1,3-benzoxathiol-2-one
CAS 627889-77-4C15H12O3S
2-Oxo-7-phenyl-1,3-benzoxathiol-5-yl 2-methylpropanoate chemical structure, C17H14O4S, CAS 879577-63-6
2-Oxo-7-phenyl-1,3-benzoxathiol-5-yl 2-methylpropanoate
CAS 879577-63-6C17H14O4S
5-Hydroxy-7-(2-methylphenyl)-2H-1,3-benzoxathiol-2-one chemical structure, C14H10O3S, CAS 1353501-83-3
5-Hydroxy-7-(2-methylphenyl)-2H-1,3-benzoxathiol-2-one
CAS 1353501-83-3C14H10O3S
7-(4-Fluorophenyl)-5-fluorosulfonyloxy-2-oxo-1,3-benzoxathiole chemical structure, C13H6F2O5S2, CAS 2411243-36-0
7-(4-Fluorophenyl)-5-fluorosulfonyloxy-2-oxo-1,3-benzoxathiole
CAS 2411243-36-0C13H6F2O5S2
7-(3-Chlorophenyl)-5-fluorosulfonyloxy-2-oxo-1,3-benzoxathiole chemical structure, C13H6ClFO5S2, CAS 2411257-31-1
7-(3-Chlorophenyl)-5-fluorosulfonyloxy-2-oxo-1,3-benzoxathiole
CAS 2411257-31-1C13H6ClFO5S2
7-(2,4-Dichlorophenyl)-5-fluorosulfonyloxy-2-oxo-1,3-benzoxathiole chemical structure, C13H5Cl2FO5S2, CAS 2418649-64-4
7-(2,4-Dichlorophenyl)-5-fluorosulfonyloxy-2-oxo-1,3-benzoxathiole
CAS 2418649-64-4C13H5Cl2FO5S2