Murcko scaffold
Ring system with 3 rings and 21 atoms
45 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 21
- Chemicals
- 45
- With full pages
- 11
Scaffold SMILES
O=C(c1ccccc1)N1CCN=C1SCc1cccnc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 45 of 45 chemicals
![(2-Methoxyphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone chemical structure, C17H17N3O2S, CAS 851807-40-4](/s/CZLLDMAWUWRUAQ-UHFFFAOYSA-N.svg)
(2-Methoxyphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone
CAS 851807-40-4C17H17N3O2S
![(2-Ethoxyphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone chemical structure, C18H19N3O2S, CAS 851807-43-7](/s/MBGRQJCZDIVYBX-UHFFFAOYSA-N.svg)
(2-Ethoxyphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone
CAS 851807-43-7C18H19N3O2S
![(2,6-Dimethoxyphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone chemical structure, C18H19N3O3S, CAS 851807-50-6](/s/OBUAAZXTKCSXAV-UHFFFAOYSA-N.svg)
(2,6-Dimethoxyphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone
CAS 851807-50-6C18H19N3O3S
N,N-Dimethyl-4-(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazole-1-carbonyl)benzenesulfonamide
CAS 851807-84-6C18H20N4O3S2
![N,N-Diethyl-4-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazole-1-carbonyl]benzenesulfonamide chemical structure, C20H24N4O3S2, CAS 851807-85-7](/s/LFVVACFQDAWRIX-UHFFFAOYSA-N.svg)
N,N-Diethyl-4-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazole-1-carbonyl]benzenesulfonamide
CAS 851807-85-7C20H24N4O3S2
(3-Nitrophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-69-7C16H14N4O3S
(2,3-Dimethoxyphenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-49-3C18H19N3O3S
(3-Bromophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-63-1C16H14BrN3OS
![(3,5-Dimethoxyphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone chemical structure, C18H19N3O3S, CAS 851807-51-7](/s/UATZXSZKXKKTCJ-UHFFFAOYSA-N.svg)
(3,5-Dimethoxyphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone
CAS 851807-51-7C18H19N3O3S
(2-Bromophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-62-0C16H14BrN3OS
![[2-(Pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]-[4-(trifluoromethyl)phenyl]methanone chemical structure, C17H14F3N3OS, CAS 851807-75-5](/s/OGULORPGJYLUMW-UHFFFAOYSA-N.svg)
[2-(Pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]-[4-(trifluoromethyl)phenyl]methanone
CAS 851807-75-5C17H14F3N3OS
(3-Methoxyphenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-41-5C17H17N3O2S
![(3-Chlorophenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone chemical structure, C16H14ClN3OS, CAS 851807-60-8](/s/GFXUQUSCIYMSID-UHFFFAOYSA-N.svg)
(3-Chlorophenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone
CAS 851807-60-8C16H14ClN3OS
![(3,4-Dimethylphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone chemical structure, C18H19N3OS, CAS 851807-38-0](/s/ZVXDEECTKQMASO-UHFFFAOYSA-N.svg)
(3,4-Dimethylphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone
CAS 851807-38-0C18H19N3OS
(4-Methyl-3-nitrophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-72-2C17H16N4O3S
(3,4-Difluorophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-66-4C16H13F2N3OS
(4-Nitrophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-70-0C16H14N4O3S
(3-Fluorophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-57-3C16H14FN3OS
(4-Bromophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-64-2C16H14BrN3OS
(2-((Pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)(p-tolyl)methanone
CAS 851807-36-8C17H17N3OS
(3,5-Dimethylphenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-37-9C18H19N3OS
(4-Ethoxyphenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-44-8C18H19N3O2S
(4-Chlorophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone
CAS 851807-61-9C16H14ClN3OS
![(4-Methoxyphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone chemical structure, C17H17N3O2S, CAS 851807-42-6](/s/WCCSRPSSSLVPDQ-UHFFFAOYSA-N.svg)
(4-Methoxyphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone
CAS 851807-42-6C17H17N3O2S
- (5-Bromo-2-chlorophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone892460-68-3C16H13BrClN3OS
- (2-((Pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)(m-tolyl)methanone851807-35-7C17H17N3OS
- [2-(Pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]-(3,4,5-triethoxyphenyl)methanone851807-55-1C22H27N3O4S
- (2-Chlorophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone851807-59-5C16H14ClN3OS
- (5-Chloro-2-methoxyphenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone851807-67-5C17H16ClN3O2S
- (2,6-Difluorophenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone851807-65-3C16H13F2N3OS
- (4-tert-Butylphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone851807-39-1C20H23N3OS
- (4-Fluorophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone851807-58-4C16H14FN3OS
- [2-(Pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]-[2-(trifluoromethyl)phenyl]methanone851807-73-3C17H14F3N3OS
- (4-Butoxyphenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone851807-46-0C20H23N3O2S
- (3,4-Diethoxyphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone851807-53-9C20H23N3O3S
- (2-Nitrophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone851807-68-6C16H14N4O3S
- (2,4-Dimethoxyphenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone851807-47-1C18H19N3O3S
- (3,4-Dimethoxyphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone851807-48-2C18H19N3O3S
- [2-(Pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]-(3,4,5-trimethoxyphenyl)methanone851807-54-0C19H21N3O4S
- (2-Methylphenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone851807-34-6C17H17N3OS
- [2-(Pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]-[3-(trifluoromethyl)phenyl]methanone851807-74-4C17H14F3N3OS
- (2-Methyl-3-nitrophenyl)-[2-(pyridin-3-ylmethylsulfanyl)-4,5-dihydroimidazol-1-yl]methanone851807-71-1C17H16N4O3S
- (3,5-Bis(trifluoromethyl)phenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone851807-76-6C18H13F6N3OS
- (2-Fluorophenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone851807-56-2C16H14FN3OS
- (4-Isopropoxyphenyl)(2-((pyridin-3-ylmethyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone851807-45-9C19H21N3O2S
Related scaffolds
Same ring framework with different atoms or bond orders
O=S(=O)(c1ccccc1)N1CCN=C1SCc1ccccc125 chemicals
O=C(Nc1ccccc1)C1CCCN1S(=O)(=O)c1ccccc116 chemicals
O=C(c1ccccc1)N1CCN=C1SCc1ccccc111 chemicals![Scaffold S=c1[nH]nc(COc2ccccc2)n1Cc1ccccc1](/scaffold/UBSDNTVPHQQNPN-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(COc2ccccc2)n1Cc1ccccc17 chemicals
O=S(=O)(c1ccccc1)N1CCN=C1SCc1cccnc16 chemicals
O=C(Nc1ccccc1)C1CCC(=O)N1Cc1ccccc15 chemicals
O=C(Nc1cccn1Cc1ccccc1)c1ccccc14 chemicals
O=C(Nc1ccccc1)c1nccn1Cc1ccccc13 chemicals
c1ccc(CSc2nccn2Cc2ccccc2)cc13 chemicals
O=S(=O)(c1ccccc1)n1nccc1COc1ccccc13 chemicals![Scaffold S=c1[nH]nc(CCc2ccccc2)n1Cc1ccccc1](/scaffold/LFXOIUDSACXIBV-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(CCc2ccccc2)n1Cc1ccccc13 chemicals
O=S(=O)(c1ccccc1)N1CCCC1CCN1CCCCC13 chemicals