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Murcko scaffold

2-(2-Oxo-2-phenylethyl)-1H-isoindole-1,3(2H)-dione scaffold

24 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
24
With full pages
5
Scaffold SMILES

O=C(CN1C(=O)c2ccccc2C1=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(2-Oxo-2-phenylethyl)-1H-isoindole-1,3(2H)-dione page
Murcko scaffold O=C(CN1C(=O)c2ccccc2C1=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

Methyl 3-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]phenyl}propanoate chemical structure, C20H17NO5, CAS 5472-64-0
Methyl 3-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]phenyl}propanoate
CAS 5472-64-0C20H17NO5
2-(2-Oxo-2-phenylethyl)-1H-isoindole-1,3(2H)-dione chemical structure, C16H11NO3, CAS 1032-67-3
2-(2-Oxo-2-phenylethyl)-1H-isoindole-1,3(2H)-dione
CAS 1032-67-3C16H11NO3
2-[2-(3-Bromo-phenyl)-2-oxo-ethyl]-isoindole-1,3-dione chemical structure, C16H10BrNO3, CAS 500356-85-4
2-[2-(3-Bromo-phenyl)-2-oxo-ethyl]-isoindole-1,3-dione
CAS 500356-85-4C16H10BrNO3
2-[2-(4-Bromophenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione chemical structure, C16H10BrNO3, CAS 794-43-4
2-[2-(4-Bromophenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
CAS 794-43-4C16H10BrNO3
2-[2-Oxo-2-[4-(trifluoromethyl)phenyl]ethyl]isoindole-1,3-dione chemical structure, C17H10F3NO3, CAS 391-10-6
2-[2-Oxo-2-[4-(trifluoromethyl)phenyl]ethyl]isoindole-1,3-dione
CAS 391-10-6C17H10F3NO3
alpha-Phthalimidopropiophenone chemical structure, C17H13NO3, CAS 19437-20-8
alpha-Phthalimidopropiophenone
CAS 19437-20-8C17H13NO3
2-[2-(4-Chlorophenyl)-2-oxoethyl]-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C16H10ClNO3, CAS 82585-51-1
2-[2-(4-Chlorophenyl)-2-oxoethyl]-2,3-dihydro-1H-isoindole-1,3-dione
CAS 82585-51-1C16H10ClNO3
2-[2-(2,4-Dichlorophenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione chemical structure, C16H9Cl2NO3, CAS 65146-53-4
2-[2-(2,4-Dichlorophenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
CAS 65146-53-4C16H9Cl2NO3
2-(2-(4-Bromophenyl)-2-oxoethyl)-5-nitro-1H-isoindole-1,3(2H)-dione chemical structure, C16H9BrN2O5, CAS 328272-56-6
2-(2-(4-Bromophenyl)-2-oxoethyl)-5-nitro-1H-isoindole-1,3(2H)-dione
CAS 328272-56-6C16H9BrN2O5
1H-Isoindole-1,3(2H)-dione, 2-[2-(2,4-dihydroxyphenyl)-2-oxoethyl]- chemical structure, C16H11NO5, CAS 65190-77-4
1H-Isoindole-1,3(2H)-dione, 2-[2-(2,4-dihydroxyphenyl)-2-oxoethyl]-
CAS 65190-77-4C16H11NO5
2-[2-(4-Fluorophenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione chemical structure, C16H10FNO3, CAS 82585-50-0
2-[2-(4-Fluorophenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
CAS 82585-50-0C16H10FNO3
2-[2-(4-Methoxyphenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione chemical structure, C17H13NO4, CAS 970-56-9
2-[2-(4-Methoxyphenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
CAS 970-56-9C17H13NO4
2-[2-(4-Bromo-2,5-dimethoxyphenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione chemical structure, C18H14BrNO5, CAS 329701-43-1
2-[2-(4-Bromo-2,5-dimethoxyphenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
CAS 329701-43-1C18H14BrNO5
2-(2-Oxo-2-(2,4,5-trimethylphenyl)ethyl)isoindoline-1,3-dione chemical structure, C19H17NO3, CAS 796999-91-2
2-(2-Oxo-2-(2,4,5-trimethylphenyl)ethyl)isoindoline-1,3-dione
CAS 796999-91-2C19H17NO3
2-[2-(2-Methoxyphenyl)-2-oxoethyl]-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C17H13NO4, CAS 216854-25-0
2-[2-(2-Methoxyphenyl)-2-oxoethyl]-2,3-dihydro-1H-isoindole-1,3-dione
CAS 216854-25-0C17H13NO4
2-[2-(4-Iodophenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione chemical structure, C16H10INO3, CAS 1253733-66-2
2-[2-(4-Iodophenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
CAS 1253733-66-2C16H10INO3
1H-Isoindole-1,3(2H)-dione, 2-[2-(4-methylphenyl)-2-oxoethyl]- chemical structure, C17H13NO3, CAS 1909-25-7
1H-Isoindole-1,3(2H)-dione, 2-[2-(4-methylphenyl)-2-oxoethyl]-
CAS 1909-25-7C17H13NO3
RefChem:382817 chemical structure, C17H13NO4, CAS 667433-79-6
RefChem:382817
CAS 667433-79-6C17H13NO4
2-(1-Hydroxy-2-oxo-2-phenylethyl)-1H-isoindole-1,3(2H)-dione chemical structure, C16H11NO4, CAS 88073-06-7
2-(1-Hydroxy-2-oxo-2-phenylethyl)-1H-isoindole-1,3(2H)-dione
CAS 88073-06-7C16H11NO4
2-(2-(3-Bromo-4-methoxyphenyl)-2-oxoethyl)isoindoline-1,3-dione chemical structure, C17H12BrNO4, CAS 923913-75-1
2-(2-(3-Bromo-4-methoxyphenyl)-2-oxoethyl)isoindoline-1,3-dione
CAS 923913-75-1C17H12BrNO4
2-[1-(4-Methoxyphenyl)-1-oxododecan-2-yl]-1H-isoindole-1,3(2H)-dione chemical structure, C27H33NO4, CAS 63424-85-1
2-[1-(4-Methoxyphenyl)-1-oxododecan-2-yl]-1H-isoindole-1,3(2H)-dione
CAS 63424-85-1C27H33NO4
N-(2-Nitrophenacyl)phthalimide chemical structure, C16H10N2O5, CAS 861379-38-6
N-(2-Nitrophenacyl)phthalimide
CAS 861379-38-6C16H10N2O5
2-(2-(3-Nitrophenyl)-2-oxoethyl)isoindoline-1,3-dione chemical structure, C16H10N2O5, CAS 1286256-04-9
2-(2-(3-Nitrophenyl)-2-oxoethyl)isoindoline-1,3-dione
CAS 1286256-04-9C16H10N2O5
2-[1-Chloro-2-(2-methylphenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione chemical structure, C17H12ClNO3, CAS 14257-06-8
2-[1-Chloro-2-(2-methylphenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
CAS 14257-06-8C17H12ClNO3