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Murcko scaffold

Ring system with 3 rings and 17 atoms

208 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
208
With full pages
49
Scaffold SMILES

C(=Cc1nc2ccccc2[nH]1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=Cc1nc2ccccc2[nH]1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 208 chemicals

2-(1H-Benzimidazol-2-yl)-3-(2-nitrophenyl)prop-2-enenitrile chemical structure, C16H10N4O2
2-(1H-Benzimidazol-2-yl)-3-(2-nitrophenyl)prop-2-enenitrile
C16H10N4O2
Ethyl 2-(1H-benzimidazol-2-yl)-3-phenylprop-2-enoate chemical structure, C18H16N2O2, CAS 83520-66-5
Ethyl 2-(1H-benzimidazol-2-yl)-3-phenylprop-2-enoate
CAS 83520-66-5C18H16N2O2
2-[2-(4-Chlorophenyl)ethenyl]-1H-benzimidazole chemical structure, C15H11ClN2, CAS 2562-87-0
2-[2-(4-Chlorophenyl)ethenyl]-1H-benzimidazole
CAS 2562-87-0C15H11ClN2
1-Methyl-2-(2-phenylethenyl)-1H-benzimidazole chemical structure, C16H14N2, CAS 59066-63-6
1-Methyl-2-(2-phenylethenyl)-1H-benzimidazole
CAS 59066-63-6C16H14N2
(Z)-2-(1H-Benzo[d]imidazol-2-yl)-3-hydroxy-3-phenylacrylonitrile chemical structure, C16H11N3O, CAS 134259-13-5
(Z)-2-(1H-Benzo[d]imidazol-2-yl)-3-hydroxy-3-phenylacrylonitrile
CAS 134259-13-5C16H11N3O
2-(1H-Benzimidazol-2-yl)-3-(4-chlorophenyl)-3-hydroxyacrylonitrile chemical structure, C16H10ClN3O, CAS 305372-46-7
2-(1H-Benzimidazol-2-yl)-3-(4-chlorophenyl)-3-hydroxyacrylonitrile
CAS 305372-46-7C16H10ClN3O
Ethyl 2-[4-[2-(1H-benzimidazol-2-yl)-2-cyanoethenyl]-2-methoxyphenoxy]acetate chemical structure, C21H19N3O4
Ethyl 2-[4-[2-(1H-benzimidazol-2-yl)-2-cyanoethenyl]-2-methoxyphenoxy]acetate
C21H19N3O4
3-(3-Fluoro-phenyl)-3-hydroxy-2-(1-methyl-1H-benzoimidazol-2-yl)-acrylonitrile chemical structure, C17H12FN3O, CAS 476283-42-8
3-(3-Fluoro-phenyl)-3-hydroxy-2-(1-methyl-1H-benzoimidazol-2-yl)-acrylonitrile
CAS 476283-42-8C17H12FN3O
2-(1H-Benzimidazol-2-yl)-3-hydroxy-3-(4-iodophenyl)acrylonitrile chemical structure, C16H10IN3O, CAS 301312-90-3
2-(1H-Benzimidazol-2-yl)-3-hydroxy-3-(4-iodophenyl)acrylonitrile
CAS 301312-90-3C16H10IN3O
(E)-2-(1-Methyl-1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxo-3-(3,4,5-trimethoxyphenyl)propanenitrile chemical structure, C20H19N3O4, CAS 5856-61-1
(E)-2-(1-Methyl-1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxo-3-(3,4,5-trimethoxyphenyl)propanenitrile
CAS 5856-61-1C20H19N3O4
[p-(Diallylaminosulfonyl)benzoyl](1,3-dihydro-2H-1,3-benzimidazol-2-ylidene)acetonitrile chemical structure, C22H20N4O3S
[p-(Diallylaminosulfonyl)benzoyl](1,3-dihydro-2H-1,3-benzimidazol-2-ylidene)acetonitrile
C22H20N4O3S
3-Hydroxy-2-(1-methylbenzimidazol-2-yl)-3-(4-propan-2-yloxyphenyl)prop-2-enenitrile chemical structure, C20H19N3O2
3-Hydroxy-2-(1-methylbenzimidazol-2-yl)-3-(4-propan-2-yloxyphenyl)prop-2-enenitrile
C20H19N3O2
2-[(2E)-1-Methyl-2,3-dihydro-1H-1,3-benzodiazol-2-ylidene]-3-(4-methylphenyl)-3-oxopropanenitrile chemical structure, C18H15N3O
2-[(2E)-1-Methyl-2,3-dihydro-1H-1,3-benzodiazol-2-ylidene]-3-(4-methylphenyl)-3-oxopropanenitrile
C18H15N3O
2-[5-Bromo-4-[2-cyano-2-(6-methyl-1H-benzimidazol-2-yl)ethenyl]-2-ethoxyphenoxy]acetic acid chemical structure, C21H18BrN3O4, CAS 882402-23-5
2-[5-Bromo-4-[2-cyano-2-(6-methyl-1H-benzimidazol-2-yl)ethenyl]-2-ethoxyphenoxy]acetic acid
CAS 882402-23-5C21H18BrN3O4
1H-Benzimidazole, 2-[2-(4-methylphenyl)ethenyl]- chemical structure, C16H14N2, CAS 156142-62-0
1H-Benzimidazole, 2-[2-(4-methylphenyl)ethenyl]-
CAS 156142-62-0C16H14N2
(E)-(1-Methyl-1,3-dihydro-2H-1,3-benzimidazol-2-ylidene)[p-(pentyloxy)benzoyl]acetonitrile chemical structure, C22H23N3O2
(E)-(1-Methyl-1,3-dihydro-2H-1,3-benzimidazol-2-ylidene)[p-(pentyloxy)benzoyl]acetonitrile
C22H23N3O2
6-Methyl-2-(2-phenylethenyl)-1H-benzimidazole chemical structure, C16H14N2, CAS 1923837-33-5
6-Methyl-2-(2-phenylethenyl)-1H-benzimidazole
CAS 1923837-33-5C16H14N2
3-(4-Iodophenyl)-2-(6-methyl-1H-benzimidazol-2-yl)prop-2-enenitrile chemical structure, C17H12IN3, CAS 5325-13-3
3-(4-Iodophenyl)-2-(6-methyl-1H-benzimidazol-2-yl)prop-2-enenitrile
CAS 5325-13-3C17H12IN3
Ethyl 2-[4-[(E)-2-(1H-benzimidazol-2-yl)-2-cyanoethenyl]-2-methoxyphenoxy]acetate chemical structure, C21H19N3O4, CAS 5533-26-6
Ethyl 2-[4-[(E)-2-(1H-benzimidazol-2-yl)-2-cyanoethenyl]-2-methoxyphenoxy]acetate
CAS 5533-26-6C21H19N3O4
2-(1H-Benzimidazol-2-yl)-3-(4-methoxyphenyl)acrylonitrile chemical structure, C17H13N3O, CAS 73724-08-0
2-(1H-Benzimidazol-2-yl)-3-(4-methoxyphenyl)acrylonitrile
CAS 73724-08-0C17H13N3O
2-(1H-Benzoimidazol-2-yl)-3-(2-nitro-phenyl)-acrylonitrile chemical structure, C16H10N4O2, CAS 131263-08-6
2-(1H-Benzoimidazol-2-yl)-3-(2-nitro-phenyl)-acrylonitrile
CAS 131263-08-6C16H10N4O2
(E)-2-(1H-Benzo[d]imidazol-2-yl)-3-(perfluorophenyl)acrylonitrile chemical structure, C16H6F5N3, CAS 5611-73-4
(E)-2-(1H-Benzo[d]imidazol-2-yl)-3-(perfluorophenyl)acrylonitrile
CAS 5611-73-4C16H6F5N3
2-(1H-Benzimidazol-2-yl)-3-(4-ethoxy-3-iodo-5-methoxyphenyl)acrylonitrile chemical structure, C19H16IN3O2, CAS 331867-64-2
2-(1H-Benzimidazol-2-yl)-3-(4-ethoxy-3-iodo-5-methoxyphenyl)acrylonitrile
CAS 331867-64-2C19H16IN3O2
(E)-2-(1H-Benzimidazol-2-yl)-3-(4-methylsulfanylphenyl)prop-2-enenitrile chemical structure, C17H13N3S, CAS 5649-71-8
(E)-2-(1H-Benzimidazol-2-yl)-3-(4-methylsulfanylphenyl)prop-2-enenitrile
CAS 5649-71-8C17H13N3S