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Murcko scaffold

1-Phenylpiperidin-2-one scaffold

543 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
543
With full pages
38
Scaffold SMILES

O=C1CCCCN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperidin-2-one page
Murcko scaffold O=C1CCCCN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 543 chemicals

Hydratropic acid, 3-(2-oxopiperidino)-2,4,6-triiodo-, sodium salt chemical structure, C14H14I3NO3, CAS 21762-28-7
Hydratropic acid, 3-(2-oxopiperidino)-2,4,6-triiodo-, sodium salt
CAS 21762-28-7C14H14I3NO3
1-Phenylpiperidin-2-one chemical structure, C11H13NO, CAS 4789-09-7
1-Phenylpiperidin-2-one
CAS 4789-09-7C11H13NO
1-[4-(Trifluoromethyl)phenyl]piperidin-2-one chemical structure, C12H12F3NO, CAS 27471-52-9
1-[4-(Trifluoromethyl)phenyl]piperidin-2-one
CAS 27471-52-9C12H12F3NO
1-[4-(Aminomethyl)phenyl]piperidin-2-one chemical structure, C12H16N2O, CAS 444002-98-6
1-[4-(Aminomethyl)phenyl]piperidin-2-one
CAS 444002-98-6C12H16N2O
3-Fluoro-4-(2-oxopiperidin-1-yl)benzaldehyde chemical structure, C12H12FNO2, CAS 1024204-75-8
3-Fluoro-4-(2-oxopiperidin-1-yl)benzaldehyde
CAS 1024204-75-8C12H12FNO2
3-Methoxy-4-(2-oxopiperidin-1-yl)benzaldehyde chemical structure, C13H15NO3, CAS 1024204-76-9
3-Methoxy-4-(2-oxopiperidin-1-yl)benzaldehyde
CAS 1024204-76-9C13H15NO3
2-Fluoro-4-(2-oxopiperidin-1-yl)benzaldehyde chemical structure, C12H12FNO2, CAS 1024204-77-0
2-Fluoro-4-(2-oxopiperidin-1-yl)benzaldehyde
CAS 1024204-77-0C12H12FNO2
2-Methoxy-4-(2-oxopiperidin-1-yl)benzaldehyde chemical structure, C13H15NO3, CAS 1024204-78-1
2-Methoxy-4-(2-oxopiperidin-1-yl)benzaldehyde
CAS 1024204-78-1C13H15NO3
3-Chloro-4-(2-oxopiperidin-1-yl)benzaldehyde chemical structure, C12H12ClNO2, CAS 1024209-05-9
3-Chloro-4-(2-oxopiperidin-1-yl)benzaldehyde
CAS 1024209-05-9C12H12ClNO2
2-Chloro-4-(2-oxopiperidin-1-yl)benzaldehyde chemical structure, C12H12ClNO2, CAS 1024209-06-0
2-Chloro-4-(2-oxopiperidin-1-yl)benzaldehyde
CAS 1024209-06-0C12H12ClNO2
4-(2-Oxopiperidin-1-yl)benzoic acid chemical structure, C12H13NO3, CAS 175153-03-4
4-(2-Oxopiperidin-1-yl)benzoic acid
CAS 175153-03-4C12H13NO3
N-(3-Methyl-4-(2-oxopiperidin-1-yl)phenyl)ethanesulfonamide chemical structure, C14H20N2O3S, CAS 953158-79-7
N-(3-Methyl-4-(2-oxopiperidin-1-yl)phenyl)ethanesulfonamide
CAS 953158-79-7C14H20N2O3S
N-[3-Methyl-4-(2-oxopiperidin-1-yl)phenyl]propane-2-sulfonamide chemical structure, C15H22N2O3S, CAS 953159-15-4
N-[3-Methyl-4-(2-oxopiperidin-1-yl)phenyl]propane-2-sulfonamide
CAS 953159-15-4C15H22N2O3S
N-[3-Methoxy-4-(2-oxopiperidin-1-yl)phenyl]methanesulfonamide chemical structure, C13H18N2O4S, CAS 941980-29-6
N-[3-Methoxy-4-(2-oxopiperidin-1-yl)phenyl]methanesulfonamide
CAS 941980-29-6C13H18N2O4S
N-(3-Methoxy-4-(2-oxopiperidin-1-yl)phenyl)ethanesulfonamide chemical structure, C14H20N2O4S, CAS 941920-35-0
N-(3-Methoxy-4-(2-oxopiperidin-1-yl)phenyl)ethanesulfonamide
CAS 941920-35-0C14H20N2O4S
N-[3-Methoxy-4-(2-oxopiperidin-1-yl)phenyl]propane-1-sulfonamide chemical structure, C15H22N2O4S, CAS 941982-98-5
N-[3-Methoxy-4-(2-oxopiperidin-1-yl)phenyl]propane-1-sulfonamide
CAS 941982-98-5C15H22N2O4S
N-(3-(2-Oxopiperidin-1-yl)phenyl)ethanesulfonamide chemical structure, C13H18N2O3S, CAS 953257-60-8
N-(3-(2-Oxopiperidin-1-yl)phenyl)ethanesulfonamide
CAS 953257-60-8C13H18N2O3S
N-(3-(2-Oxopiperidin-1-yl)phenyl)propane-1-sulfonamide chemical structure, C14H20N2O3S, CAS 941939-48-6
N-(3-(2-Oxopiperidin-1-yl)phenyl)propane-1-sulfonamide
CAS 941939-48-6C14H20N2O3S
N-[4-Methyl-3-(2-oxopiperidin-1-yl)phenyl]propane-1-sulfonamide chemical structure, C15H22N2O3S, CAS 953184-14-0
N-[4-Methyl-3-(2-oxopiperidin-1-yl)phenyl]propane-1-sulfonamide
CAS 953184-14-0C15H22N2O3S
N-(4-Methoxy-3-(2-oxopiperidin-1-yl)phenyl)methanesulfonamide chemical structure, C13H18N2O4S, CAS 941893-67-0
N-(4-Methoxy-3-(2-oxopiperidin-1-yl)phenyl)methanesulfonamide
CAS 941893-67-0C13H18N2O4S
N-[4-Methoxy-3-(2-oxopiperidin-1-yl)phenyl]propane-2-sulfonamide chemical structure, C15H22N2O4S, CAS 952965-60-5
N-[4-Methoxy-3-(2-oxopiperidin-1-yl)phenyl]propane-2-sulfonamide
CAS 952965-60-5C15H22N2O4S
2,2-Dimethyl-N-[4-(2-oxopiperidin-1-yl)phenyl]propanamide chemical structure, C16H22N2O2, CAS 941978-33-2
2,2-Dimethyl-N-[4-(2-oxopiperidin-1-yl)phenyl]propanamide
CAS 941978-33-2C16H22N2O2
N-[4-(2-Oxopiperidin-1-yl)phenyl]propanamide chemical structure, C14H18N2O2, CAS 923081-68-9
N-[4-(2-Oxopiperidin-1-yl)phenyl]propanamide
CAS 923081-68-9C14H18N2O2
3,3-Dimethyl-N-[3-methyl-4-(2-oxopiperidin-1-yl)phenyl]butanamide chemical structure, C18H26N2O2, CAS 941978-39-8
3,3-Dimethyl-N-[3-methyl-4-(2-oxopiperidin-1-yl)phenyl]butanamide
CAS 941978-39-8C18H26N2O2