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Murcko scaffold

Ring system with 3 rings and 24 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
12
With full pages
2
Scaffold SMILES

O=C(CSc1nccc(=O)n1-c1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nccc(=O)n1-c1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

N-(2-Chlorophenyl)-2-[(4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]acetamide chemical structure, C18H14ClN3O3S, CAS 713080-83-2
N-(2-Chlorophenyl)-2-[(4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]acetamide
CAS 713080-83-2C18H14ClN3O3S
2-[[1,6-Dihydro-4-hydroxy-1-(4-methoxyphenyl)-6-oxo-2-pyrimidinyl]thio]-N-(4-methylphenyl)acetamide chemical structure, C20H19N3O4S, CAS 415722-07-5
2-[[1,6-Dihydro-4-hydroxy-1-(4-methoxyphenyl)-6-oxo-2-pyrimidinyl]thio]-N-(4-methylphenyl)acetamide
CAS 415722-07-5C20H19N3O4S
2-[(4-Hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-phenylacetamide chemical structure, C18H15N3O3S, CAS 373613-13-9
2-[(4-Hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-phenylacetamide
CAS 373613-13-9C18H15N3O3S
2-{[4-Hydroxy-1-(2-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-(2-methylphenyl)acetamide chemical structure, C20H19N3O4S, CAS 5674-36-2
2-{[4-Hydroxy-1-(2-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-(2-methylphenyl)acetamide
CAS 5674-36-2C20H19N3O4S
2-((5-Ethyl-4-hydroxy-6-oxo-1-(o-tolyl)-1,6-dihydropyrimidin-2-yl)thio)-N-(4-methoxyphenyl)acetamide chemical structure, C22H23N3O4S, CAS 373370-01-5
2-((5-Ethyl-4-hydroxy-6-oxo-1-(o-tolyl)-1,6-dihydropyrimidin-2-yl)thio)-N-(4-methoxyphenyl)acetamide
CAS 373370-01-5C22H23N3O4S
N-(4-Ethoxyphenyl)-2-((1-(4-fluorophenyl)-4-hydroxy-5-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide chemical structure, C21H20FN3O4S, CAS 428842-68-6
N-(4-Ethoxyphenyl)-2-((1-(4-fluorophenyl)-4-hydroxy-5-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide
CAS 428842-68-6C21H20FN3O4S
2-[(4-Hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(2-methoxyphenyl)acetamide chemical structure, C19H17N3O4S, CAS 374541-31-8
2-[(4-Hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(2-methoxyphenyl)acetamide
CAS 374541-31-8C19H17N3O4S
N-(4-Bromophenyl)-2-[(4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]acetamide chemical structure, C18H14BrN3O3S, CAS 374600-39-2
N-(4-Bromophenyl)-2-[(4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]acetamide
CAS 374600-39-2C18H14BrN3O3S
2-[(4-Hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(2-methylphenyl)acetamide chemical structure, C19H17N3O3S, CAS 374547-53-2
2-[(4-Hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(2-methylphenyl)acetamide
CAS 374547-53-2C19H17N3O3S
N-(4-Chlorophenyl)-2-((4-hydroxy-6-oxo-1-(o-tolyl)-1,6-dihydropyrimidin-2-yl)thio)acetamide chemical structure, C19H16ClN3O3S, CAS 373613-76-4
N-(4-Chlorophenyl)-2-((4-hydroxy-6-oxo-1-(o-tolyl)-1,6-dihydropyrimidin-2-yl)thio)acetamide
CAS 373613-76-4C19H16ClN3O3S
N-(3-Chlorophenyl)-2-[(5-ethyl-4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]propanamide chemical structure, C21H20ClN3O3S, CAS 827003-71-4
N-(3-Chlorophenyl)-2-[(5-ethyl-4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]propanamide
CAS 827003-71-4C21H20ClN3O3S
2-[(5-Ethyl-4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(4-sulfamoylphenyl)propanamide chemical structure, C21H22N4O5S2, CAS 827005-60-7
2-[(5-Ethyl-4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(4-sulfamoylphenyl)propanamide
CAS 827005-60-7C21H22N4O5S2