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Murcko scaffold

Ring system with 3 rings and 23 atoms

65 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
65
With full pages
14
Scaffold SMILES

O=C(COc1ccccc1)Nc1ccccc1N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)Nc1ccccc1N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 65 chemicals

Methyl 3-{[(4-methoxyphenoxy)acetyl]amino}-4-(4-methyl-1-piperazinyl)benzoate chemical structure, C22H27N3O5, CAS 847481-99-6
Methyl 3-{[(4-methoxyphenoxy)acetyl]amino}-4-(4-methyl-1-piperazinyl)benzoate
CAS 847481-99-6C22H27N3O5
2-(4-Chloro-3,5-dimethylphenoxy)-N-[2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]acetamide chemical structure, C24H30ClN3O3, CAS 708290-98-6
2-(4-Chloro-3,5-dimethylphenoxy)-N-[2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]acetamide
CAS 708290-98-6C24H30ClN3O3
2-(3-Methylphenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide chemical structure, C20H25N3O4S, CAS 724449-78-9
2-(3-Methylphenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide
CAS 724449-78-9C20H25N3O4S
2-(4-Methylphenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide chemical structure, C20H25N3O4S, CAS 724449-79-0
2-(4-Methylphenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide
CAS 724449-79-0C20H25N3O4S
2-(2,4-Dimethylphenoxy)-N-[2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]acetamide chemical structure, C24H31N3O3, CAS 708251-42-7
2-(2,4-Dimethylphenoxy)-N-[2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]acetamide
CAS 708251-42-7C24H31N3O3
N-[3-Chloro-2-(4-ethylpiperazin-1-yl)phenyl]-2-phenoxyacetamide chemical structure, C20H24ClN3O2, CAS 723754-29-8
N-[3-Chloro-2-(4-ethylpiperazin-1-yl)phenyl]-2-phenoxyacetamide
CAS 723754-29-8C20H24ClN3O2
2-(4-Chloro-2-methylphenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide chemical structure, C20H24ClN3O4S, CAS 757944-19-7
2-(4-Chloro-2-methylphenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide
CAS 757944-19-7C20H24ClN3O4S
2-(2-Methylphenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide chemical structure, C20H25N3O4S, CAS 838869-92-4
2-(2-Methylphenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide
CAS 838869-92-4C20H25N3O4S
N-[3-Chloro-2-(4-ethylpiperazin-1-yl)phenyl]-2-(4-methoxyphenoxy)acetamide chemical structure, C21H26ClN3O3, CAS 797782-16-2
N-[3-Chloro-2-(4-ethylpiperazin-1-yl)phenyl]-2-(4-methoxyphenoxy)acetamide
CAS 797782-16-2C21H26ClN3O3
2-(4-Methoxyphenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide chemical structure, C20H25N3O5S, CAS 838851-65-3
2-(4-Methoxyphenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide
CAS 838851-65-3C20H25N3O5S
2-(4-Chlorophenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide chemical structure, C19H22ClN3O4S, CAS 797782-22-0
2-(4-Chlorophenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide
CAS 797782-22-0C19H22ClN3O4S
N-[2-(4-Methylpiperazin-1-yl)phenyl]-2-phenoxyacetamide chemical structure, C19H23N3O2, CAS 717831-96-4
N-[2-(4-Methylpiperazin-1-yl)phenyl]-2-phenoxyacetamide
CAS 717831-96-4C19H23N3O2
2-(4-Bromophenoxy)-N-[2-(4-methylpiperazin-1-yl)phenyl]acetamide chemical structure, C19H22BrN3O2, CAS 713502-78-4
2-(4-Bromophenoxy)-N-[2-(4-methylpiperazin-1-yl)phenyl]acetamide
CAS 713502-78-4C19H22BrN3O2
2-(4-Chlorophenoxy)-N-[2-(4-methylpiperazin-1-yl)phenyl]acetamide chemical structure, C19H22ClN3O2, CAS 714207-98-4
2-(4-Chlorophenoxy)-N-[2-(4-methylpiperazin-1-yl)phenyl]acetamide
CAS 714207-98-4C19H22ClN3O2
2-(2-Isopropyl-5-methylphenoxy)-N-[2-(4-methyl-1-piperazinyl)phenyl]acetamide chemical structure, C23H31N3O2, CAS 827002-93-7
2-(2-Isopropyl-5-methylphenoxy)-N-[2-(4-methyl-1-piperazinyl)phenyl]acetamide
CAS 827002-93-7C23H31N3O2
N-[2-(4-Acetylpiperazin-1-yl)phenyl]-2-(4-chloro-3,5-dimethylphenoxy)acetamide chemical structure, C22H26ClN3O3, CAS 835896-02-1
N-[2-(4-Acetylpiperazin-1-yl)phenyl]-2-(4-chloro-3,5-dimethylphenoxy)acetamide
CAS 835896-02-1C22H26ClN3O3
2-(2-Isopropyl-5-methylphenoxy)-N-[2-(4-propionyl-1-piperazinyl)phenyl]acetamide chemical structure, C25H33N3O3, CAS 765926-43-0
2-(2-Isopropyl-5-methylphenoxy)-N-[2-(4-propionyl-1-piperazinyl)phenyl]acetamide
CAS 765926-43-0C25H33N3O3
2-(3-Methylphenoxy)-N-[2-(4-propanoylpiperazin-1-yl)phenyl]acetamide chemical structure, C22H27N3O3, CAS 694446-93-0
2-(3-Methylphenoxy)-N-[2-(4-propanoylpiperazin-1-yl)phenyl]acetamide
CAS 694446-93-0C22H27N3O3
2-(4-Bromophenoxy)-N-[2-(4-propanoylpiperazin-1-yl)phenyl]acetamide chemical structure, C21H24BrN3O3, CAS 694447-17-1
2-(4-Bromophenoxy)-N-[2-(4-propanoylpiperazin-1-yl)phenyl]acetamide
CAS 694447-17-1C21H24BrN3O3
2-(4-Chloro-3,5-dimethylphenoxy)-N-[2-(4-propanoylpiperazin-1-yl)phenyl]acetamide chemical structure, C23H28ClN3O3, CAS 694450-75-4
2-(4-Chloro-3,5-dimethylphenoxy)-N-[2-(4-propanoylpiperazin-1-yl)phenyl]acetamide
CAS 694450-75-4C23H28ClN3O3
N-[5-Chloro-2-(4-propanoylpiperazin-1-yl)phenyl]-2-(3,5-dimethylphenoxy)acetamide chemical structure, C23H28ClN3O3, CAS 830350-29-3
N-[5-Chloro-2-(4-propanoylpiperazin-1-yl)phenyl]-2-(3,5-dimethylphenoxy)acetamide
CAS 830350-29-3C23H28ClN3O3
2-(4-Chlorophenoxy)-2-methyl-N-[2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]propanamide chemical structure, C24H30ClN3O3, CAS 831250-11-4
2-(4-Chlorophenoxy)-2-methyl-N-[2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]propanamide
CAS 831250-11-4C24H30ClN3O3
2-(4-Chloro-3,5-dimethylphenoxy)-N-[5-chloro-2-(4-propanoylpiperazin-1-yl)phenyl]acetamide chemical structure, C23H27Cl2N3O3, CAS 765926-79-2
2-(4-Chloro-3,5-dimethylphenoxy)-N-[5-chloro-2-(4-propanoylpiperazin-1-yl)phenyl]acetamide
CAS 765926-79-2C23H27Cl2N3O3
2-(4-Chloro-3-methylphenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide chemical structure, C20H24ClN3O4S, CAS 838895-44-6
2-(4-Chloro-3-methylphenoxy)-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide
CAS 838895-44-6C20H24ClN3O4S