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Murcko scaffold

Ring system with 3 rings and 24 atoms

14 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 24
Chemicals: 14
With full pages: 5

Scaffold SMILES

O=C(CSc1nc(=O)ccn1-c1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1nc(=O)ccn1-c1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

2-(6-Amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanyl-N-(4-methylphenyl)acetamide chemical structure, C19H18N4O2S, CAS 354539-38-1

2-(6-Amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanyl-N-(4-methylphenyl)acetamide

CAS 354539-38-1C₁₉H₁₈N₄O₂S

Methyl 2-({[(6-amino-4-oxo-1-phenyl-1,4-dihydropyrimidin-2-yl)sulfanyl]acetyl}amino)benzoate chemical structure, C20H18N4O4S, CAS 684234-18-2

Methyl 2-({[(6-amino-4-oxo-1-phenyl-1,4-dihydropyrimidin-2-yl)sulfanyl]acetyl}amino)benzoate

CAS 684234-18-2C₂₀H₁₈N₄O₄S

Methyl 3-({[(6-amino-4-oxo-1-phenyl-1,4-dihydro-2-pyrimidinyl)thio]acetyl}amino)benzoate chemical structure, C20H18N4O4S, CAS 692268-04-5

Methyl 3-({[(6-amino-4-oxo-1-phenyl-1,4-dihydro-2-pyrimidinyl)thio]acetyl}amino)benzoate

CAS 692268-04-5C₂₀H₁₈N₄O₄S

Methyl 4-({[(6-amino-4-oxo-1-phenyl-1,4-dihydro-2-pyrimidinyl)thio]acetyl}amino)benzoate chemical structure, C20H18N4O4S, CAS 684234-16-0

Methyl 4-({[(6-amino-4-oxo-1-phenyl-1,4-dihydro-2-pyrimidinyl)thio]acetyl}amino)benzoate

CAS 684234-16-0C₂₀H₁₈N₄O₄S

2-[6-Amino-1-(3-methylphenyl)-4-oxopyrimidin-2-yl]sulfanyl-N-(2-cyanophenyl)acetamide chemical structure, C20H17N5O2S, CAS 693228-80-7

2-[6-Amino-1-(3-methylphenyl)-4-oxopyrimidin-2-yl]sulfanyl-N-(2-cyanophenyl)acetamide

CAS 693228-80-7C₂₀H₁₇N₅O₂S

Methyl 4-[({[6-amino-1-(3-methylphenyl)-4-oxo-1,4-dihydropyrimidin-2-yl]sulfanyl}acetyl)amino]benzoate chemical structure, C21H20N4O4S, CAS 824976-89-8

Methyl 4-[({[6-amino-1-(3-methylphenyl)-4-oxo-1,4-dihydropyrimidin-2-yl]sulfanyl}acetyl)amino]benzoate

CAS 824976-89-8C₂₁H₂₀N₄O₄S

N-(4-Acetylphenyl)-2-(6-amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanylacetamide chemical structure, C20H18N4O3S, CAS 831211-23-5

N-(4-Acetylphenyl)-2-(6-amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanylacetamide

CAS 831211-23-5C₂₀H₁₈N₄O₃S

2-(6-Amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanyl-N-phenylpropanamide chemical structure, C19H18N4O2S, CAS 678546-19-5

2-(6-Amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanyl-N-phenylpropanamide

CAS 678546-19-5C₁₉H₁₈N₄O₂S

2-{[6-Amino-1-(3-methylphenyl)-4-oxo-1,4-dihydropyrimidin-2-yl]sulfanyl}-N-(4-sulfamoylphenyl)propanamide chemical structure, C20H21N5O4S2, CAS 685121-62-4

2-{[6-Amino-1-(3-methylphenyl)-4-oxo-1,4-dihydropyrimidin-2-yl]sulfanyl}-N-(4-sulfamoylphenyl)propanamide

CAS 685121-62-4C₂₀H₂₁N₅O₄S₂

2-(6-Amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanyl-N-(4-methylphenyl)propanamide chemical structure, C20H20N4O2S, CAS 685121-65-7

2-(6-Amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanyl-N-(4-methylphenyl)propanamide

CAS 685121-65-7C₂₀H₂₀N₄O₂S

2-(6-Amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanyl-N-(4-chlorophenyl)propanamide chemical structure, C19H17ClN4O2S, CAS 694479-08-8

2-(6-Amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanyl-N-(4-chlorophenyl)propanamide

CAS 694479-08-8C₁₉H₁₇ClN₄O₂S

2-(6-Amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanyl-N-(3-chlorophenyl)propanamide chemical structure, C19H17ClN4O2S, CAS 706777-88-0

2-(6-Amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanyl-N-(3-chlorophenyl)propanamide

CAS 706777-88-0C₁₉H₁₇ClN₄O₂S

Ethyl 4-({2-[(6-amino-4-oxo-1-phenyl-1,4-dihydropyrimidin-2-yl)sulfanyl]propanoyl}amino)benzoate chemical structure, C22H22N4O4S, CAS 708281-66-7

Ethyl 4-({2-[(6-amino-4-oxo-1-phenyl-1,4-dihydropyrimidin-2-yl)sulfanyl]propanoyl}amino)benzoate

CAS 708281-66-7C₂₂H₂₂N₄O₄S

2-[[2-(6-Amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanylacetyl]amino]benzamide chemical structure, C19H17N5O3S, CAS 824979-10-4

2-[[2-(6-Amino-4-oxo-1-phenylpyrimidin-2-yl)sulfanylacetyl]amino]benzamide

CAS 824979-10-4C₁₉H₁₇N₅O₃S