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Murcko scaffold

Ring system with 4 rings and 26 atoms

55 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 26
Chemicals: 55
With full pages: 2

Scaffold SMILES

O=C(CC1C(=O)N(Cc2ccccc2)c2ccccc21)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CC1C(=O)N(Cc2ccccc2)c2ccccc21)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

1-[(4-Chlorophenyl)methyl]-3-[2-(4-chlorophenyl)-2-oxoethyl]-3-hydroxyindol-2-one chemical structure, C23H17Cl2NO3, CAS 402779-74-2

1-[(4-Chlorophenyl)methyl]-3-[2-(4-chlorophenyl)-2-oxoethyl]-3-hydroxyindol-2-one

CAS 402779-74-2C₂₃H₁₇Cl₂NO₃

3-[2-(4-Aminophenyl)-2-oxoethyl]-1-[(4-chlorophenyl)methyl]-3-hydroxyindol-2-one chemical structure, C23H19ClN2O3, CAS 362507-23-1

3-[2-(4-Aminophenyl)-2-oxoethyl]-1-[(4-chlorophenyl)methyl]-3-hydroxyindol-2-one

CAS 362507-23-1C₂₃H₁₉ClN₂O₃

3-[2-(3-Aminophenyl)-2-oxoethyl]-1-[(4-chlorophenyl)methyl]-3-hydroxyindol-2-one chemical structure, C23H19ClN2O3, CAS 362507-26-4

3-[2-(3-Aminophenyl)-2-oxoethyl]-1-[(4-chlorophenyl)methyl]-3-hydroxyindol-2-one

CAS 362507-26-4C₂₃H₁₉ClN₂O₃

1-(4-Chlorobenzyl)-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C24H20ClNO4, CAS 362507-14-0

1-(4-Chlorobenzyl)-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one

CAS 362507-14-0C₂₄H₂₀ClNO₄

1-(4-Chlorobenzyl)-3-hydroxy-3-[2-(4-methylphenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C24H20ClNO3, CAS 362506-99-8

1-(4-Chlorobenzyl)-3-hydroxy-3-[2-(4-methylphenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one

CAS 362506-99-8C₂₄H₂₀ClNO₃

1-(4-Chlorobenzyl)-3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C23H17ClFNO3, CAS 362507-05-9

1-(4-Chlorobenzyl)-3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one

CAS 362507-05-9C₂₃H₁₇ClFNO₃

1-(4-Chlorobenzyl)-3-hydroxy-3-[2-(3-nitrophenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C23H17ClN2O5, CAS 362507-20-8

1-(4-Chlorobenzyl)-3-hydroxy-3-[2-(3-nitrophenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one

CAS 362507-20-8C₂₃H₁₇ClN₂O₅

1-(4-Chlorobenzyl)-3-[2-(2,4-dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C25H22ClNO5, CAS 362507-44-6

1-(4-Chlorobenzyl)-3-[2-(2,4-dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one

CAS 362507-44-6C₂₅H₂₂ClNO₅

1-(4-Chlorobenzyl)-3-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C25H22ClNO5, CAS 362507-17-3

1-(4-Chlorobenzyl)-3-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one

CAS 362507-17-3C₂₅H₂₂ClNO₅

3-[2-(4-Bromophenyl)-2-oxoethyl]-1-(4-chlorobenzyl)-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C23H17BrClNO3, CAS 362507-08-2

3-[2-(4-Bromophenyl)-2-oxoethyl]-1-(4-chlorobenzyl)-3-hydroxy-1,3-dihydro-2H-indol-2-one

CAS 362507-08-2C₂₃H₁₇BrClNO₃

3-[2-(3-Bromophenyl)-2-oxoethyl]-1-(4-chlorobenzyl)-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C23H17BrClNO3, CAS 404381-65-3

3-[2-(3-Bromophenyl)-2-oxoethyl]-1-(4-chlorobenzyl)-3-hydroxy-1,3-dihydro-2H-indol-2-one

CAS 404381-65-3C₂₃H₁₇BrClNO₃

3-Hydroxy-3-[2-(2-hydroxyphenyl)-2-oxoethyl]-1-(2-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H21NO4, CAS 383893-25-2

3-Hydroxy-3-[2-(2-hydroxyphenyl)-2-oxoethyl]-1-(2-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 383893-25-2C₂₄H₂₁NO₄

3-Hydroxy-1-(2-methylbenzyl)-3-[2-(3-nitrophenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C24H20N2O5, CAS 864717-73-7

3-Hydroxy-1-(2-methylbenzyl)-3-[2-(3-nitrophenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one

CAS 864717-73-7C₂₄H₂₀N₂O₅

3-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(2-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C26H25NO5, CAS 384357-23-7

3-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(2-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 384357-23-7C₂₆H₂₅NO₅

1-Benzyl-3-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C25H23NO5, CAS 370849-92-6

1-Benzyl-3-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one

CAS 370849-92-6C₂₅H₂₃NO₅

1-Benzyl-3-[2-(2,5-dimethylphenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C25H23NO3, CAS 432515-43-0

1-Benzyl-3-[2-(2,5-dimethylphenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one

CAS 432515-43-0C₂₅H₂₃NO₃

1-Benzyl-3-hydroxy-3-[2-(4-methoxy-3-nitrophenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C24H20N2O6, CAS 442567-89-7

1-Benzyl-3-hydroxy-3-[2-(4-methoxy-3-nitrophenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one

CAS 442567-89-7C₂₄H₂₀N₂O₆

1-[(4-Chlorophenyl)methyl]-3-hydroxy-3-[2-(4-nitrophenyl)-2-oxoethyl]indol-2-one chemical structure, C23H17ClN2O5, CAS 434290-37-6

1-[(4-Chlorophenyl)methyl]-3-hydroxy-3-[2-(4-nitrophenyl)-2-oxoethyl]indol-2-one

CAS 434290-37-6C₂₃H₁₇ClN₂O₅

1-Benzyl-5-bromo-3-hydroxy-3-(2-oxo-2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C23H18BrNO3, CAS 690671-65-9

1-Benzyl-5-bromo-3-hydroxy-3-(2-oxo-2-phenylethyl)-1,3-dihydro-2H-indol-2-one

CAS 690671-65-9C₂₃H₁₈BrNO₃

3-Hydroxy-3-[2-(2-methoxyphenyl)-2-oxoethyl]-1-(2-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C25H23NO4, CAS 442640-68-8

3-Hydroxy-3-[2-(2-methoxyphenyl)-2-oxoethyl]-1-(2-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 442640-68-8C₂₅H₂₃NO₄

3-[2-(4-Ethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(2-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C26H25NO4, CAS 442640-64-4

3-[2-(4-Ethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(2-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 442640-64-4C₂₆H₂₅NO₄

3-[2-(2,4-Dimethylphenyl)-2-oxoethyl]-3-hydroxy-1-(2-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C26H25NO3, CAS 442640-48-4

3-[2-(2,4-Dimethylphenyl)-2-oxoethyl]-3-hydroxy-1-(2-methylbenzyl)-1,3-dihydro-2H-indol-2-one

CAS 442640-48-4C₂₆H₂₅NO₃

1-(4-Chlorobenzyl)-3-hydroxy-3-[2-(2-methoxyphenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C24H20ClNO4, CAS 442640-76-8

1-(4-Chlorobenzyl)-3-hydroxy-3-[2-(2-methoxyphenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one

CAS 442640-76-8C₂₄H₂₀ClNO₄

1-(4-Chlorobenzyl)-3-[2-(2,5-dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C25H22ClNO5, CAS 690687-17-3

1-(4-Chlorobenzyl)-3-[2-(2,5-dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one

CAS 690687-17-3C₂₅H₂₂ClNO₅