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Murcko scaffold

Ring system with 3 rings and 19 atoms

136 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 136
With full pages: 10

Scaffold SMILES

O=C1C=C(C(=O)c2cccs2)C(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C=C(C(=O)c2cccs2)C(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 136 chemicals

5-(2,5-Dimethoxyphenyl)-1-(2-(dimethylamino)ethyl)-3-hydroxy-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C21H24N2O5S, CAS 636991-52-1

5-(2,5-Dimethoxyphenyl)-1-(2-(dimethylamino)ethyl)-3-hydroxy-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 636991-52-1C₂₁H₂₄N₂O₅S

1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(thiophene-2-carbonyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one chemical structure, C21H24N2O3S, CAS 380879-33-4

1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(thiophene-2-carbonyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one

CAS 380879-33-4C₂₁H₂₄N₂O₃S

1-[3-(Dimethylamino)propyl]-5-(2-fluorophenyl)-3-hydroxy-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C20H21FN2O3S, CAS 380559-42-2

1-[3-(Dimethylamino)propyl]-5-(2-fluorophenyl)-3-hydroxy-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 380559-42-2C₂₀H₂₁FN₂O₃S

1-[3-(Dimethylamino)propyl]-3-hydroxy-5-(3-nitrophenyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one chemical structure, C20H21N3O5S, CAS 378756-84-4

1-[3-(Dimethylamino)propyl]-3-hydroxy-5-(3-nitrophenyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one

CAS 378756-84-4C₂₀H₂₁N₃O₅S

(4E)-5-(4-Chlorophenyl)-1-[3-(dimethylamino)propyl]-4-[hydroxy(thiophen-2-yl)methylidene]pyrrolidine-2,3-dione chemical structure, C20H21ClN2O3S, CAS 380889-44-1

(4E)-5-(4-Chlorophenyl)-1-[3-(dimethylamino)propyl]-4-[hydroxy(thiophen-2-yl)methylidene]pyrrolidine-2,3-dione

CAS 380889-44-1C₂₀H₂₁ClN₂O₃S

1-(3-(Dimethylamino)propyl)-3-hydroxy-5-(4-nitrophenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C20H21N3O5S, CAS 381201-54-3

1-(3-(Dimethylamino)propyl)-3-hydroxy-5-(4-nitrophenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 381201-54-3C₂₀H₂₁N₃O₅S

1-(3-(Dimethylamino)propyl)-3-hydroxy-5-phenyl-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C20H22N2O3S, CAS 381205-79-4

1-(3-(Dimethylamino)propyl)-3-hydroxy-5-phenyl-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 381205-79-4C₂₀H₂₂N₂O₃S

1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(4-isopropylphenyl)-4-(thien-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H26N2O3S, CAS 381172-06-1

1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(4-isopropylphenyl)-4-(thien-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 381172-06-1C₂₂H₂₆N₂O₃S

2-(3,4-Dichlorophenyl)-1-[3-(dimethylamino)propyl]-4-hydroxy-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C20H20Cl2N2O3S, CAS 381172-74-3

2-(3,4-Dichlorophenyl)-1-[3-(dimethylamino)propyl]-4-hydroxy-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one

CAS 381172-74-3C₂₀H₂₀Cl₂N₂O₃S

5-(3,4-Dimethoxyphenyl)-1-[2-(dimethylamino)ethyl]-3-hydroxy-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H24N2O5S, CAS 380544-63-8

5-(3,4-Dimethoxyphenyl)-1-[2-(dimethylamino)ethyl]-3-hydroxy-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 380544-63-8C₂₁H₂₄N₂O₅S

1-(2-(Dimethylamino)ethyl)-5-(2-fluorophenyl)-3-hydroxy-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C19H19FN2O3S, CAS 380882-72-4

1-(2-(Dimethylamino)ethyl)-5-(2-fluorophenyl)-3-hydroxy-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 380882-72-4C₁₉H₁₉FN₂O₃S

1-[3-(Dimethylamino)propyl]-3-hydroxy-5-(4-methoxyphenyl)-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H24N2O4S, CAS 378222-42-5

1-[3-(Dimethylamino)propyl]-3-hydroxy-5-(4-methoxyphenyl)-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 378222-42-5C₂₁H₂₄N₂O₄S

1-[3-(Dimethylamino)propyl]-5-(3-bromophenyl)-3-hydroxy-4-(2-thienylcarbonyl)-3-pyrrolin-2-one chemical structure, C20H21BrN2O3S, CAS 380881-14-1

1-[3-(Dimethylamino)propyl]-5-(3-bromophenyl)-3-hydroxy-4-(2-thienylcarbonyl)-3-pyrrolin-2-one

CAS 380881-14-1C₂₀H₂₁BrN₂O₃S

1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(4-methylphenyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C20H22N2O3S, CAS 432021-60-8

1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(4-methylphenyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 432021-60-8C₂₀H₂₂N₂O₃S

1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(4-methoxyphenyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C20H22N2O4S, CAS 431910-03-1

1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(4-methoxyphenyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 431910-03-1C₂₀H₂₂N₂O₄S

5-(2,3-Dimethoxyphenyl)-1-(2-(dimethylamino)ethyl)-3-hydroxy-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C21H24N2O5S, CAS 371144-40-0

5-(2,3-Dimethoxyphenyl)-1-(2-(dimethylamino)ethyl)-3-hydroxy-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one

CAS 371144-40-0C₂₁H₂₄N₂O₅S

3-Hydroxy-1-(3-methoxypropyl)-5-phenyl-4-(2-thienylcarbonyl)-3-pyrrolin-2-one chemical structure, C19H19NO4S, CAS 433255-69-7

3-Hydroxy-1-(3-methoxypropyl)-5-phenyl-4-(2-thienylcarbonyl)-3-pyrrolin-2-one

CAS 433255-69-7C₁₉H₁₉NO₄S

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-5-(4-iodophenyl)-1-(2-methoxyethyl)pyrrolidine-2,3-dione chemical structure, C18H16INO4S, CAS 370870-25-0

(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-5-(4-iodophenyl)-1-(2-methoxyethyl)pyrrolidine-2,3-dione

CAS 370870-25-0C₁₈H₁₆INO₄S

(4E)-5-(4-tert-Butylphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(2-methoxyethyl)pyrrolidine-2,3-dione chemical structure, C22H25NO4S, CAS 433257-67-1

(4E)-5-(4-tert-Butylphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(2-methoxyethyl)pyrrolidine-2,3-dione

CAS 433257-67-1C₂₂H₂₅NO₄S

(4E)-1-[3-(Dimethylamino)propyl]-5-(4-ethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]pyrrolidine-2,3-dione chemical structure, C22H26N2O4S, CAS 371128-09-5

(4E)-1-[3-(Dimethylamino)propyl]-5-(4-ethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]pyrrolidine-2,3-dione

CAS 371128-09-5C₂₂H₂₆N₂O₄S

(4E)-1-[2-(Diethylamino)ethyl]-4-[hydroxy(thiophen-2-yl)methylidene]-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione chemical structure, C24H30N2O6S, CAS 371207-53-3

(4E)-1-[2-(Diethylamino)ethyl]-4-[hydroxy(thiophen-2-yl)methylidene]-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione

CAS 371207-53-3C₂₄H₃₀N₂O₆S

(4E)-5-(3-Bromophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(2-methoxyethyl)pyrrolidine-2,3-dione chemical structure, C18H16BrNO4S, CAS 385391-78-6

(4E)-5-(3-Bromophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(2-methoxyethyl)pyrrolidine-2,3-dione

CAS 385391-78-6C₁₈H₁₆BrNO₄S

(4E)-5-(3-Chlorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(2-methoxyethyl)pyrrolidine-2,3-dione chemical structure, C18H16ClNO4S, CAS 371219-64-6

(4E)-5-(3-Chlorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(2-methoxyethyl)pyrrolidine-2,3-dione

CAS 371219-64-6C₁₈H₁₆ClNO₄S

(4E)-1-[3-(Dimethylamino)propyl]-4-[hydroxy(thiophen-2-yl)methylidene]-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione chemical structure, C23H28N2O6S, CAS 385419-09-0

(4E)-1-[3-(Dimethylamino)propyl]-4-[hydroxy(thiophen-2-yl)methylidene]-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione

CAS 385419-09-0C₂₃H₂₈N₂O₆S