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Murcko scaffold

Ring system with 3 rings and 19 atoms

212 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 212
With full pages: 25

Scaffold SMILES

O=C1C=C(C(=O)c2ccco2)C(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C=C(C(=O)c2ccco2)C(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 212 chemicals

5-(3-Allyloxy-phenyl)-1-(2-dimethylamino-ethyl)-3-hydroxy-4-(5-methyl-furan-2-carbonyl)-1,5-dihydro-pyrrol-2-one chemical structure, C23H26N2O5, CAS 620116-98-5

5-(3-Allyloxy-phenyl)-1-(2-dimethylamino-ethyl)-3-hydroxy-4-(5-methyl-furan-2-carbonyl)-1,5-dihydro-pyrrol-2-one

CAS 620116-98-5C₂₃H₂₆N₂O₅

1-[3-(Diethylamino)propyl]-2-(4-ethoxyphenyl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-2H-pyrrol-5-one chemical structure, C25H32N2O5, CAS 615277-64-0

1-[3-(Diethylamino)propyl]-2-(4-ethoxyphenyl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-2H-pyrrol-5-one

CAS 615277-64-0C₂₅H₃₂N₂O₅

5-(4-BR-PH)-4-(2-Furoyl)-3-HO-1-(3-methoxypropyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C19H18BrNO5, CAS 609796-97-6

5-(4-BR-PH)-4-(2-Furoyl)-3-HO-1-(3-methoxypropyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 609796-97-6C₁₉H₁₈BrNO₅

5-(3-(Allyloxy)phenyl)-1-(2-(diethylamino)ethyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one chemical structure, C24H28N2O5, CAS 619273-10-8

5-(3-(Allyloxy)phenyl)-1-(2-(diethylamino)ethyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one

CAS 619273-10-8C₂₄H₂₈N₂O₅

1-(2-(Diethylamino)ethyl)-4-(furan-2-carbonyl)-3-hydroxy-5-(3-propoxyphenyl)-1H-pyrrol-2(5H)-one chemical structure, C24H30N2O5, CAS 619272-35-4

1-(2-(Diethylamino)ethyl)-4-(furan-2-carbonyl)-3-hydroxy-5-(3-propoxyphenyl)-1H-pyrrol-2(5H)-one

CAS 619272-35-4C₂₄H₃₀N₂O₅

1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-5-(3-propoxyphenyl)-1H-pyrrol-2(5H)-one chemical structure, C24H30N2O5, CAS 619289-28-0

1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-5-(3-propoxyphenyl)-1H-pyrrol-2(5H)-one

CAS 619289-28-0C₂₄H₃₀N₂O₅

1-[3-(Diethylamino)propyl]-4-(2-furylcarbonyl)-3-hydroxy-5-(4-prop-2-enyloxyph enyl)-3-pyrrolin-2-one chemical structure, C25H30N2O5, CAS 636991-70-3

1-[3-(Diethylamino)propyl]-4-(2-furylcarbonyl)-3-hydroxy-5-(4-prop-2-enyloxyph enyl)-3-pyrrolin-2-one

CAS 636991-70-3C₂₅H₃₀N₂O₅

1-(3-(Dimethylamino)propyl)-4-(furan-2-carbonyl)-3-hydroxy-5-(4-isopropoxyphenyl)-1H-pyrrol-2(5H)-one chemical structure, C23H28N2O5, CAS 636991-69-0

1-(3-(Dimethylamino)propyl)-4-(furan-2-carbonyl)-3-hydroxy-5-(4-isopropoxyphenyl)-1H-pyrrol-2(5H)-one

CAS 636991-69-0C₂₃H₂₈N₂O₅

1-(3-(Diethylamino)propyl)-5-(2,5-dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one chemical structure, C24H30N2O6, CAS 638134-36-8

1-(3-(Diethylamino)propyl)-5-(2,5-dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one

CAS 638134-36-8C₂₄H₃₀N₂O₆

1-(3-(Dimethylamino)propyl)-4-(furan-2-carbonyl)-3-hydroxy-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one chemical structure, C20H21N3O6, CAS 380546-97-4

1-(3-(Dimethylamino)propyl)-4-(furan-2-carbonyl)-3-hydroxy-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one

CAS 380546-97-4C₂₀H₂₁N₃O₆

5-(3-Bromophenyl)-1-(3-(dimethylamino)propyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one chemical structure, C20H21BrN2O4, CAS 381197-37-1

5-(3-Bromophenyl)-1-(3-(dimethylamino)propyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one

CAS 381197-37-1C₂₀H₂₁BrN₂O₄

1-(3-(Dimethylamino)propyl)-4-(furan-2-carbonyl)-3-hydroxy-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one chemical structure, C20H21N3O6, CAS 380576-53-4

1-(3-(Dimethylamino)propyl)-4-(furan-2-carbonyl)-3-hydroxy-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one

CAS 380576-53-4C₂₀H₂₁N₃O₆

2-(3,4-Dimethoxyphenyl)-1-[3-(dimethylamino)propyl]-3-(furan-2-carbonyl)-4-hydroxy-2H-pyrrol-5-one chemical structure, C22H26N2O6, CAS 378763-56-5

2-(3,4-Dimethoxyphenyl)-1-[3-(dimethylamino)propyl]-3-(furan-2-carbonyl)-4-hydroxy-2H-pyrrol-5-one

CAS 378763-56-5C₂₂H₂₆N₂O₆

5-(3,4-Dichlorophenyl)-1-[2-(dimethylamino)ethyl]-4-(furan-2-carbonyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C19H18Cl2N2O4, CAS 378773-30-9

5-(3,4-Dichlorophenyl)-1-[2-(dimethylamino)ethyl]-4-(furan-2-carbonyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one

CAS 378773-30-9C₁₉H₁₈Cl₂N₂O₄

5-(2,4-Dimethoxyphenyl)-1-[3-(dimethylamino)propyl]-4-(furan-2-ylcarbonyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H26N2O6, CAS 381695-27-8

5-(2,4-Dimethoxyphenyl)-1-[3-(dimethylamino)propyl]-4-(furan-2-ylcarbonyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one

CAS 381695-27-8C₂₂H₂₆N₂O₆

1-[3-(Dimethylamino)propyl]-4-(furan-2-carbonyl)-3-hydroxy-5-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H24N2O5, CAS 381191-93-1

1-[3-(Dimethylamino)propyl]-4-(furan-2-carbonyl)-3-hydroxy-5-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one

CAS 381191-93-1C₂₁H₂₄N₂O₅

1-[2-(Dimethylamino)ethyl]-5-(2-fluorophenyl)-4-(2-furoyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one chemical structure, C19H19FN2O4, CAS 380587-53-1

1-[2-(Dimethylamino)ethyl]-5-(2-fluorophenyl)-4-(2-furoyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one

CAS 380587-53-1C₁₉H₁₉FN₂O₄

1-[3-(Dimethylamino)propyl]-5-(2-fluorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C20H21FN2O4, CAS 378774-31-3

1-[3-(Dimethylamino)propyl]-5-(2-fluorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one

CAS 378774-31-3C₂₀H₂₁FN₂O₄

1-[3-(Dimethylamino)propyl]-5-(4-fluorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C20H21FN2O4, CAS 380595-69-7

1-[3-(Dimethylamino)propyl]-5-(4-fluorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one

CAS 380595-69-7C₂₀H₂₁FN₂O₄

5-(4-Chlorophenyl)-1-(3-(dimethylamino)propyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one chemical structure, C20H21ClN2O4, CAS 378752-27-3

5-(4-Chlorophenyl)-1-(3-(dimethylamino)propyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one

CAS 378752-27-3C₂₀H₂₁ClN₂O₄

(4E)-5-(2-Fluorophenyl)-4-[furan-2-yl(hydroxy)methylidene]-1-(2-methoxyethyl)pyrrolidine-2,3-dione chemical structure, C18H16FNO5, CAS 487038-94-8

(4E)-5-(2-Fluorophenyl)-4-[furan-2-yl(hydroxy)methylidene]-1-(2-methoxyethyl)pyrrolidine-2,3-dione

CAS 487038-94-8C₁₈H₁₆FNO₅

4-(Furan-2-ylcarbonyl)-3-hydroxy-5-(4-hydroxyphenyl)-1-(2-methoxyethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C18H17NO6, CAS 505079-42-5

4-(Furan-2-ylcarbonyl)-3-hydroxy-5-(4-hydroxyphenyl)-1-(2-methoxyethyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 505079-42-5C₁₈H₁₇NO₆

(4E)-5-(3-Chlorophenyl)-4-[furan-2-yl(hydroxy)methylidene]-1-(3-methoxypropyl)pyrrolidine-2,3-dione chemical structure, C19H18ClNO5, CAS 371233-52-2

(4E)-5-(3-Chlorophenyl)-4-[furan-2-yl(hydroxy)methylidene]-1-(3-methoxypropyl)pyrrolidine-2,3-dione

CAS 371233-52-2C₁₉H₁₈ClNO₅

(4E)-4-[Hydroxy(5-methylfuran-2-yl)methylidene]-1-(2-methoxyethyl)-5-(3-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C20H21NO6, CAS 371140-65-7

(4E)-4-[Hydroxy(5-methylfuran-2-yl)methylidene]-1-(2-methoxyethyl)-5-(3-methoxyphenyl)pyrrolidine-2,3-dione

CAS 371140-65-7C₂₀H₂₁NO₆