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Murcko scaffold

3-(1H-Benzimidazol-1-yl)-1-phenylpyrrolidine-2,5-dione scaffold

22 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
22
With full pages
4
Scaffold SMILES

O=C1CC(n2cnc3ccccc32)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-(1H-Benzimidazol-1-yl)-1-phenylpyrrolidine-2,5-dione page
Murcko scaffold O=C1CC(n2cnc3ccccc32)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

3-(1H-Benzimidazol-1-yl)-1-phenylpyrrolidine-2,5-dione chemical structure, C17H13N3O2, CAS 49692-03-7
3-(1H-Benzimidazol-1-yl)-1-phenylpyrrolidine-2,5-dione
CAS 49692-03-7C17H13N3O2
3-(1H-Benzimidazol-1-yl)-1-(4-fluorophenyl)pyrrolidine-2,5-dione chemical structure, C17H12FN3O2, CAS 49692-06-0
3-(1H-Benzimidazol-1-yl)-1-(4-fluorophenyl)pyrrolidine-2,5-dione
CAS 49692-06-0C17H12FN3O2
3-(2-Methyl-1H-benzimidazol-1-yl)-1-(3-methylphenyl)pyrrolidine-2,5-dione chemical structure, C19H17N3O2, CAS 372503-58-7
3-(2-Methyl-1H-benzimidazol-1-yl)-1-(3-methylphenyl)pyrrolidine-2,5-dione
CAS 372503-58-7C19H17N3O2
3-(Benzimidazol-1-yl)-1-(3,4-dichlorophenyl)pyrrolidine-2,5-dione chemical structure, C17H11Cl2N3O2, CAS 443645-35-0
3-(Benzimidazol-1-yl)-1-(3,4-dichlorophenyl)pyrrolidine-2,5-dione
CAS 443645-35-0C17H11Cl2N3O2
Ethyl 4-[3-(2-methyl-1H-benzimidazol-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoate chemical structure, C21H19N3O4, CAS 587848-91-7
Ethyl 4-[3-(2-methyl-1H-benzimidazol-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoate
CAS 587848-91-7C21H19N3O4
3-(5,6-Dimethyl-1H-benzimidazol-1-yl)-1-(4-methoxyphenyl)-2,5-pyrrolidinedione chemical structure, C20H19N3O3, CAS 49692-13-9
3-(5,6-Dimethyl-1H-benzimidazol-1-yl)-1-(4-methoxyphenyl)-2,5-pyrrolidinedione
CAS 49692-13-9C20H19N3O3
1-(4-Chlorophenyl)-3-(5,6-dimethylbenzimidazol-1-yl)pyrrolidine-2,5-dione chemical structure, C19H16ClN3O2, CAS 49692-08-2
1-(4-Chlorophenyl)-3-(5,6-dimethylbenzimidazol-1-yl)pyrrolidine-2,5-dione
CAS 49692-08-2C19H16ClN3O2
3-(Benzimidazol-1-yl)-1-(3-ethoxyphenyl)pyrrolidine-2,5-dione chemical structure, C19H17N3O3, CAS 590379-40-1
3-(Benzimidazol-1-yl)-1-(3-ethoxyphenyl)pyrrolidine-2,5-dione
CAS 590379-40-1C19H17N3O3
3-(Benzimidazol-1-yl)-1-(2,4-dimethylphenyl)pyrrolidine-2,5-dione chemical structure, C19H17N3O2, CAS 444079-83-8
3-(Benzimidazol-1-yl)-1-(2,4-dimethylphenyl)pyrrolidine-2,5-dione
CAS 444079-83-8C19H17N3O2
3-[2-(Hydroxymethyl)benzimidazol-1-yl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C19H17N3O4, CAS 590380-19-1
3-[2-(Hydroxymethyl)benzimidazol-1-yl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione
CAS 590380-19-1C19H17N3O4
1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-(2-methylbenzimidazol-1-yl)pyrrolidine-2,5-dione chemical structure, C19H13ClF3N3O2, CAS 587849-73-8
1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-(2-methylbenzimidazol-1-yl)pyrrolidine-2,5-dione
CAS 587849-73-8C19H13ClF3N3O2
3-(5,6-Dimethylbenzimidazol-1-yl)-1-(2-fluorophenyl)pyrrolidine-2,5-dione chemical structure, C19H16FN3O2, CAS 590378-31-7
3-(5,6-Dimethylbenzimidazol-1-yl)-1-(2-fluorophenyl)pyrrolidine-2,5-dione
CAS 590378-31-7C19H16FN3O2
1-(3-Chlorophenyl)-3-(5,6-dimethylbenzimidazol-1-yl)pyrrolidine-2,5-dione chemical structure, C19H16ClN3O2, CAS 696624-46-1
1-(3-Chlorophenyl)-3-(5,6-dimethylbenzimidazol-1-yl)pyrrolidine-2,5-dione
CAS 696624-46-1C19H16ClN3O2
3-(1H-Benzimidazol-1-yl)-1-(4-ethoxyphenyl)pyrrolidine-2,5-dione chemical structure, C19H17N3O3, CAS 337493-86-4
3-(1H-Benzimidazol-1-yl)-1-(4-ethoxyphenyl)pyrrolidine-2,5-dione
CAS 337493-86-4C19H17N3O3
3-(Benzimidazol-1-yl)-1-(3-chlorophenyl)pyrrolidine-2,5-dione chemical structure, C17H12ClN3O2, CAS 331422-86-7
3-(Benzimidazol-1-yl)-1-(3-chlorophenyl)pyrrolidine-2,5-dione
CAS 331422-86-7C17H12ClN3O2
1-(4-Bromophenyl)-3-(2-methylbenzimidazolyl)azolidine-2,5-dione chemical structure, C18H14BrN3O2, CAS 62955-53-7
1-(4-Bromophenyl)-3-(2-methylbenzimidazolyl)azolidine-2,5-dione
CAS 62955-53-7C18H14BrN3O2
3-(Benzimidazol-1-yl)-1-(4-bromophenyl)pyrrolidine-2,5-dione chemical structure, C17H12BrN3O2, CAS 62908-91-2
3-(Benzimidazol-1-yl)-1-(4-bromophenyl)pyrrolidine-2,5-dione
CAS 62908-91-2C17H12BrN3O2
3-(Benzimidazol-1-yl)-1-(4-chlorophenyl)pyrrolidine-2,5-dione chemical structure, C17H12ClN3O2, CAS 52712-19-3
3-(Benzimidazol-1-yl)-1-(4-chlorophenyl)pyrrolidine-2,5-dione
CAS 52712-19-3C17H12ClN3O2
3-(1H-Benzo[d]imidazol-1-yl)-1-p-tolylpyrrolidine-2,5-dione chemical structure, C18H15N3O2, CAS 62908-90-1
3-(1H-Benzo[d]imidazol-1-yl)-1-p-tolylpyrrolidine-2,5-dione
CAS 62908-90-1C18H15N3O2
3-(Benzimidazol-1-yl)-1-(4-nitrophenyl)pyrrolidine-2,5-dione chemical structure, C17H12N4O4, CAS 49692-24-2
3-(Benzimidazol-1-yl)-1-(4-nitrophenyl)pyrrolidine-2,5-dione
CAS 49692-24-2C17H12N4O4
Ethyl 4-[3-(5,6-dimethyl-1H-benzimidazol-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoate chemical structure, C22H21N3O4, CAS 62908-94-5
Ethyl 4-[3-(5,6-dimethyl-1H-benzimidazol-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoate
CAS 62908-94-5C22H21N3O4
3-(1H-Benzimidazol-1-yl)-1-(3-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C18H15N3O3, CAS 5543-54-4
3-(1H-Benzimidazol-1-yl)-1-(3-methoxyphenyl)pyrrolidine-2,5-dione
CAS 5543-54-4C18H15N3O3