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Murcko scaffold

Ring system with 4 rings and 23 atoms

54 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
54
With full pages
3
Scaffold SMILES

O=C1Nc2ccccc2C1=C1SC(=S)N(c2ccccc2)C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1Nc2ccccc2C1=C1SC(=S)N(c2ccccc2)C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 54 chemicals

1,3-Dihydro-3-[3-(2-methoxyphenyl)-4-oxo-2-thioxo-5-thiazolidinylidene]-1-methyl-2H-indol-2-one chemical structure, C19H14N2O3S2, CAS 306279-86-7
1,3-Dihydro-3-[3-(2-methoxyphenyl)-4-oxo-2-thioxo-5-thiazolidinylidene]-1-methyl-2H-indol-2-one
CAS 306279-86-7C19H14N2O3S2
3-[5-(1-Methyl-2-oxoindol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzoic acid chemical structure, C19H12N2O4S2
3-[5-(1-Methyl-2-oxoindol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzoic acid
C19H12N2O4S2
(3Z)-1-Methyl-3-[3-(4-methylphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C19H14N2O2S2, CAS 306280-04-6
(3Z)-1-Methyl-3-[3-(4-methylphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 306280-04-6C19H14N2O2S2
Ethyl {(3Z)-3-[3-(4-bromophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate chemical structure, C21H15BrN2O4S2, CAS 301680-08-0
Ethyl {(3Z)-3-[3-(4-bromophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate
CAS 301680-08-0C21H15BrN2O4S2
(3Z)-3-[3-(2,3-Dimethylphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-methyl-1,3-dihydro-2H-indol-2-one chemical structure, C20H16N2O2S2, CAS 5749-54-2
(3Z)-3-[3-(2,3-Dimethylphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-methyl-1,3-dihydro-2H-indol-2-one
CAS 5749-54-2C20H16N2O2S2
(3Z)-1-Butyl-3-(4-oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C21H18N2O2S2, CAS 306279-70-9
(3Z)-1-Butyl-3-(4-oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one
CAS 306279-70-9C21H18N2O2S2
(3Z)-3-[3-(4-Methoxyphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-methyl-1,3-dihydro-2H-indol-2-one chemical structure, C19H14N2O3S2, CAS 306279-87-8
(3Z)-3-[3-(4-Methoxyphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-methyl-1,3-dihydro-2H-indol-2-one
CAS 306279-87-8C19H14N2O3S2
(3Z)-1-Acetyl-3-[3-(2-fluorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C19H11FN2O3S2, CAS 375833-98-0
(3Z)-1-Acetyl-3-[3-(2-fluorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 375833-98-0C19H11FN2O3S2
(3Z)-1-Methyl-3-(4-oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C18H12N2O2S2, CAS 306322-07-6
(3Z)-1-Methyl-3-(4-oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one
CAS 306322-07-6C18H12N2O2S2
3-[5-(1-Methyl-2-oxo-2,3-dihydro-1H-indol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzoic acid chemical structure, C19H12N2O4S2
3-[5-(1-Methyl-2-oxo-2,3-dihydro-1H-indol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzoic acid
C19H12N2O4S2
3-(5-(1-Methyl-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid chemical structure, C19H12N2O4S2, CAS 306322-09-8
3-(5-(1-Methyl-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid
CAS 306322-09-8C19H12N2O4S2
(3Z)-1-Ethyl-3-(4-oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C19H14N2O2S2, CAS 304893-09-2
(3Z)-1-Ethyl-3-(4-oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one
CAS 304893-09-2C19H14N2O2S2
(3Z)-3-(4-Oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1-pentyl-1,3-dihydro-2H-indol-2-one chemical structure, C22H20N2O2S2, CAS 304893-10-5
(3Z)-3-(4-Oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1-pentyl-1,3-dihydro-2H-indol-2-one
CAS 304893-10-5C22H20N2O2S2
(3Z)-1-Hexyl-3-(4-oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C23H22N2O2S2, CAS 304893-11-6
(3Z)-1-Hexyl-3-(4-oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one
CAS 304893-11-6C23H22N2O2S2
(3Z)-1-Heptyl-3-(4-oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C24H24N2O2S2, CAS 304893-12-7
(3Z)-1-Heptyl-3-(4-oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one
CAS 304893-12-7C24H24N2O2S2
3-[3-(3-Chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-ethyl-1,3-dihydro-2H-indol-2-one chemical structure, C19H13ClN2O2S2, CAS 304893-13-8
3-[3-(3-Chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-ethyl-1,3-dihydro-2H-indol-2-one
CAS 304893-13-8C19H13ClN2O2S2
(3Z)-3-[3-(3-Chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-pentyl-1,3-dihydro-2H-indol-2-one chemical structure, C22H19ClN2O2S2, CAS 304893-14-9
(3Z)-3-[3-(3-Chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-pentyl-1,3-dihydro-2H-indol-2-one
CAS 304893-14-9C22H19ClN2O2S2
3-(3-Chlorophenyl)-5-(1-hexyl-2-oxo-1,2-dihydro-3H-indol-3-yliden)-2-thioxo-1,3-thiazolan-4-one chemical structure, C23H21ClN2O2S2, CAS 304893-15-0
3-(3-Chlorophenyl)-5-(1-hexyl-2-oxo-1,2-dihydro-3H-indol-3-yliden)-2-thioxo-1,3-thiazolan-4-one
CAS 304893-15-0C23H21ClN2O2S2
(3Z)-3-[3-(3-Chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-heptyl-1,3-dihydro-2H-indol-2-one chemical structure, C24H23ClN2O2S2, CAS 304893-16-1
(3Z)-3-[3-(3-Chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-heptyl-1,3-dihydro-2H-indol-2-one
CAS 304893-16-1C24H23ClN2O2S2
(3Z)-3-[3-(4-Bromophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-ethyl-1,3-dihydro-2H-indol-2-one chemical structure, C19H13BrN2O2S2, CAS 304893-17-2
(3Z)-3-[3-(4-Bromophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-ethyl-1,3-dihydro-2H-indol-2-one
CAS 304893-17-2C19H13BrN2O2S2
(3Z)-3-[3-(4-Bromophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-pentyl-1,3-dihydro-2H-indol-2-one chemical structure, C22H19BrN2O2S2, CAS 304893-18-3
(3Z)-3-[3-(4-Bromophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-pentyl-1,3-dihydro-2H-indol-2-one
CAS 304893-18-3C22H19BrN2O2S2
(3Z)-3-[3-(4-Bromophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-hexyl-1,3-dihydro-2H-indol-2-one chemical structure, C23H21BrN2O2S2, CAS 304893-19-4
(3Z)-3-[3-(4-Bromophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-hexyl-1,3-dihydro-2H-indol-2-one
CAS 304893-19-4C23H21BrN2O2S2
(3Z)-3-[3-(4-Bromophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-heptyl-1,3-dihydro-2H-indol-2-one chemical structure, C24H23BrN2O2S2, CAS 304893-20-7
(3Z)-3-[3-(4-Bromophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-heptyl-1,3-dihydro-2H-indol-2-one
CAS 304893-20-7C24H23BrN2O2S2
(5Z)-5-(1-Ethyl-2-oxoindol-3-ylidene)-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H16N2O3S2, CAS 302559-66-6
(5Z)-5-(1-Ethyl-2-oxoindol-3-ylidene)-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 302559-66-6C20H16N2O3S2