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Murcko scaffold

Ring system with 4 rings and 22 atoms

38 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
38
With full pages
2
Scaffold SMILES

O=C1N=c2ccccc2=C1c1cn(-c2ccccc2)c(=S)s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1N=c2ccccc2=C1c1cn(-c2ccccc2)c(=S)s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

(3Z)-5-Bromo-3-[3-(4-hydroxyphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C17H9BrN2O3S2, CAS 303790-34-3
(3Z)-5-Bromo-3-[3-(4-hydroxyphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 303790-34-3C17H9BrN2O3S2
(5Z)-3-(3,4-Dimethylphenyl)-5-(2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C19H14N2O2S2, CAS 307342-80-9
(5Z)-3-(3,4-Dimethylphenyl)-5-(2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 307342-80-9C19H14N2O2S2
(Z)-5-(5-Bromo-2-oxoindolin-3-ylidene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one chemical structure, C18H11BrN2O3S2, CAS 307525-46-8
(Z)-5-(5-Bromo-2-oxoindolin-3-ylidene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one
CAS 307525-46-8C18H11BrN2O3S2
(Z)-3-(3-Chlorophenyl)-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-4-one chemical structure, C17H9ClN2O2S2, CAS 305377-62-2
(Z)-3-(3-Chlorophenyl)-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-4-one
CAS 305377-62-2C17H9ClN2O2S2
(Z)-5-(2-Oxoindolin-3-ylidene)-2-thioxo-3-(o-tolyl)thiazolidin-4-one chemical structure, C18H12N2O2S2, CAS 307525-39-9
(Z)-5-(2-Oxoindolin-3-ylidene)-2-thioxo-3-(o-tolyl)thiazolidin-4-one
CAS 307525-39-9C18H12N2O2S2
3-(4-Oxo-2-thioxo-3-m-tolyl-thiazolidin-5-ylidene)-1,3-dihydro-indol-2-one chemical structure, C18H12N2O2S2, CAS 307525-32-2
3-(4-Oxo-2-thioxo-3-m-tolyl-thiazolidin-5-ylidene)-1,3-dihydro-indol-2-one
CAS 307525-32-2C18H12N2O2S2
(Z)-5-(2-Oxoindolin-3-ylidene)-3-phenyl-2-thioxothiazolidin-4-one chemical structure, C17H10N2O2S2, CAS 303798-59-6
(Z)-5-(2-Oxoindolin-3-ylidene)-3-phenyl-2-thioxothiazolidin-4-one
CAS 303798-59-6C17H10N2O2S2
(3Z)-5-Methyl-3-(4-oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C18H12N2O2S2, CAS 301304-70-1
(3Z)-5-Methyl-3-(4-oxo-3-phenyl-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one
CAS 301304-70-1C18H12N2O2S2
(3Z)-3-[3-(4-Methoxyphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C18H12N2O3S2, CAS 302558-79-8
(3Z)-3-[3-(4-Methoxyphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 302558-79-8C18H12N2O3S2
(Z)-5-(5-Bromo-2-oxoindolin-3-ylidene)-3-(4-ethoxyphenyl)-2-thioxothiazolidin-4-one chemical structure, C19H13BrN2O3S2, CAS 300817-94-1
(Z)-5-(5-Bromo-2-oxoindolin-3-ylidene)-3-(4-ethoxyphenyl)-2-thioxothiazolidin-4-one
CAS 300817-94-1C19H13BrN2O3S2
(3Z)-5-Bromo-3-[3-(2-methoxyphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C18H11BrN2O3S2, CAS 307525-10-6
(3Z)-5-Bromo-3-[3-(2-methoxyphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 307525-10-6C18H11BrN2O3S2
(Z)-3-(2-Methoxyphenyl)-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-4-one chemical structure, C18H12N2O3S2, CAS 307525-08-2
(Z)-3-(2-Methoxyphenyl)-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-4-one
CAS 307525-08-2C18H12N2O3S2
(3E)-3-[3-(2-Chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C17H9ClN2O2S2, CAS 300817-54-3
(3E)-3-[3-(2-Chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 300817-54-3C17H9ClN2O2S2
(3Z)-5-Bromo-3-[3-(4-chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C17H8BrClN2O2S2, CAS 384358-59-2
(3Z)-5-Bromo-3-[3-(4-chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 384358-59-2C17H8BrClN2O2S2
(5Z)-3-(4-Chlorophenyl)-5-(2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C17H9ClN2O2S2, CAS 370851-05-1
(5Z)-3-(4-Chlorophenyl)-5-(2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 370851-05-1C17H9ClN2O2S2
(Z)-5-(2-Oxoindolin-3-ylidene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one chemical structure, C18H9F3N2O2S2, CAS 5670-42-8
(Z)-5-(2-Oxoindolin-3-ylidene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one
CAS 5670-42-8C18H9F3N2O2S2
(5Z)-5-(5-Bromo-2-oxo-1H-indol-3-ylidene)-3-(3,4-dimethylphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C19H13BrN2O2S2, CAS 307342-81-0
(5Z)-5-(5-Bromo-2-oxo-1H-indol-3-ylidene)-3-(3,4-dimethylphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 307342-81-0C19H13BrN2O2S2
(5Z)-5-(5-Bromo-2-oxo-1H-indol-3-ylidene)-3-(3-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C18H11BrN2O3S2, CAS 306323-88-6
(5Z)-5-(5-Bromo-2-oxo-1H-indol-3-ylidene)-3-(3-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 306323-88-6C18H11BrN2O3S2
4-(4-Oxo-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-3-yl)benzoic acid chemical structure, C18H10N2O4S2, CAS 305376-86-7
4-(4-Oxo-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-3-yl)benzoic acid
CAS 305376-86-7C18H10N2O4S2
(Z)-5-(2-Oxoindolin-3-ylidene)-2-thioxo-3-(p-tolyl)thiazolidin-4-one chemical structure, C18H12N2O2S2, CAS 307525-24-2
(Z)-5-(2-Oxoindolin-3-ylidene)-2-thioxo-3-(p-tolyl)thiazolidin-4-one
CAS 307525-24-2C18H12N2O2S2
(Z)-3-(4-Hydroxyphenyl)-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-4-one chemical structure, C17H10N2O3S2, CAS 300817-93-0
(Z)-3-(4-Hydroxyphenyl)-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-4-one
CAS 300817-93-0C17H10N2O3S2
(Z)-5-(5-Bromo-2-oxoindolin-3-ylidene)-2-thioxo-3-(o-tolyl)thiazolidin-4-one chemical structure, C18H11BrN2O2S2, CAS 307525-42-4
(Z)-5-(5-Bromo-2-oxoindolin-3-ylidene)-2-thioxo-3-(o-tolyl)thiazolidin-4-one
CAS 307525-42-4C18H11BrN2O2S2
(3E)-5-Bromo-3-[3-(4-bromophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C17H8Br2N2O2S2, CAS 301689-80-5
(3E)-5-Bromo-3-[3-(4-bromophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 301689-80-5C17H8Br2N2O2S2
(3Z)-3-[3-(4-Ethoxyphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C19H14N2O3S2, CAS 299950-44-0
(3Z)-3-[3-(4-Ethoxyphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 299950-44-0C19H14N2O3S2