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Murcko scaffold

Ring system with 3 rings and 24 atoms

25 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 24
Chemicals: 25
With full pages: 5

Scaffold SMILES

O=C(Nc1ccccc1)C1CCCN(S(=O)(=O)c2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1ccccc1)C1CCCN(S(=O)(=O)c2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

1-(4-Methylbenzenesulfonyl)-N-phenylpiperidine-3-carboxamide chemical structure, C19H22N2O3S, CAS 304476-77-5

1-(4-Methylbenzenesulfonyl)-N-phenylpiperidine-3-carboxamide

CAS 304476-77-5C₁₉H₂₂N₂O₃S

Methyl (4-((3-((3-(trifluoromethyl)phenyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)carbamate chemical structure, C21H22F3N3O5S, CAS 326032-31-9

Methyl (4-((3-((3-(trifluoromethyl)phenyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)carbamate

CAS 326032-31-9C₂₁H₂₂F₃N₃O₅S

Methyl N-[4-({3-[methyl(phenyl)carbamoyl]piperidin-1-yl}sulfonyl)phenyl]carbamate chemical structure, C21H25N3O5S, CAS 326872-02-0

Methyl N-[4-({3-[methyl(phenyl)carbamoyl]piperidin-1-yl}sulfonyl)phenyl]carbamate

CAS 326872-02-0C₂₁H₂₅N₃O₅S

Methyl (4-((3-((4-(dimethylamino)phenyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)carbamate chemical structure, C22H28N4O5S, CAS 326615-86-5

Methyl (4-((3-((4-(dimethylamino)phenyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)carbamate

CAS 326615-86-5C₂₂H₂₈N₄O₅S

Methyl (4-((3-((3-chloro-4-methylphenyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)carbamate chemical structure, C21H24ClN3O5S, CAS 326616-90-4

Methyl (4-((3-((3-chloro-4-methylphenyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)carbamate

CAS 326616-90-4C₂₁H₂₄ClN₃O₅S

Methyl (4-((3-((2-bromophenyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)carbamate chemical structure, C20H22BrN3O5S, CAS 326025-10-9

Methyl (4-((3-((2-bromophenyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)carbamate

CAS 326025-10-9C₂₀H₂₂BrN₃O₅S

Methyl (4-((3-((3-methoxyphenyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)carbamate chemical structure, C21H25N3O6S, CAS 305342-53-4

Methyl (4-((3-((3-methoxyphenyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)carbamate

CAS 305342-53-4C₂₁H₂₅N₃O₆S

N-(3-Bromophenyl)-1-(3-chloro-4-methoxyphenyl)sulfonylpiperidine-3-carboxamide chemical structure, C19H20BrClN2O4S, CAS 824976-63-8

N-(3-Bromophenyl)-1-(3-chloro-4-methoxyphenyl)sulfonylpiperidine-3-carboxamide

CAS 824976-63-8C₁₉H₂₀BrClN₂O₄S

1-(3-Chloro-4-methoxyphenyl)sulfonyl-N-(2-ethyl-6-methylphenyl)piperidine-3-carboxamide chemical structure, C22H27ClN2O4S, CAS 713507-87-0

1-(3-Chloro-4-methoxyphenyl)sulfonyl-N-(2-ethyl-6-methylphenyl)piperidine-3-carboxamide

CAS 713507-87-0C₂₂H₂₇ClN₂O₄S

Methyl 2-[({1-[(4-fluorophenyl)sulfonyl]-3-piperidinyl}carbonyl)amino]benzoate chemical structure, C20H21FN2O5S, CAS 827011-60-9

Methyl 2-[({1-[(4-fluorophenyl)sulfonyl]-3-piperidinyl}carbonyl)amino]benzoate

CAS 827011-60-9C₂₀H₂₁FN₂O₅S

Ethyl 4-[[1-(4-fluorophenyl)sulfonylpiperidine-3-carbonyl]amino]benzoate chemical structure, C21H23FN2O5S, CAS 833436-28-5

Ethyl 4-[[1-(4-fluorophenyl)sulfonylpiperidine-3-carbonyl]amino]benzoate

CAS 833436-28-5C₂₁H₂₃FN₂O₅S

N-(3-Fluorophenyl)-1-(phenylsulfonyl)piperidine-3-carboxamide chemical structure, C18H19FN2O3S, CAS 838884-92-7

N-(3-Fluorophenyl)-1-(phenylsulfonyl)piperidine-3-carboxamide

CAS 838884-92-7C₁₈H₁₉FN₂O₃S

1-(3,4-Dimethoxyphenyl)sulfonyl-N-[3-(trifluoromethyl)phenyl]piperidine-3-carboxamide chemical structure, C21H23F3N2O5S, CAS 838886-09-2

1-(3,4-Dimethoxyphenyl)sulfonyl-N-[3-(trifluoromethyl)phenyl]piperidine-3-carboxamide

CAS 838886-09-2C₂₁H₂₃F₃N₂O₅S

N-(4-Chlorophenyl)-1-tosylpiperidine-3-carboxamide chemical structure, C19H21ClN2O3S, CAS 562867-76-9

N-(4-Chlorophenyl)-1-tosylpiperidine-3-carboxamide

CAS 562867-76-9C₁₉H₂₁ClN₂O₃S

1-[(4-Methylphenyl)sulfonyl]-N-(2,4,6-trimethylphenyl)-3-piperidinecarboxamide chemical structure, C22H28N2O3S, CAS 626210-50-2

1-[(4-Methylphenyl)sulfonyl]-N-(2,4,6-trimethylphenyl)-3-piperidinecarboxamide

CAS 626210-50-2C₂₂H₂₈N₂O₃S

Methyl (4-((3-((4-ethoxyphenyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)carbamate chemical structure, C22H27N3O6S, CAS 326866-31-3

Methyl (4-((3-((4-ethoxyphenyl)carbamoyl)piperidin-1-yl)sulfonyl)phenyl)carbamate

CAS 326866-31-3C₂₂H₂₇N₃O₆S

Methyl N-[4-({3-[(3,4-dimethylphenyl)carbamoyl]piperidin-1-yl}sulfonyl)phenyl]carbamate chemical structure, C22H27N3O5S, CAS 326616-91-5

Methyl N-[4-({3-[(3,4-dimethylphenyl)carbamoyl]piperidin-1-yl}sulfonyl)phenyl]carbamate

CAS 326616-91-5C₂₂H₂₇N₃O₅S

(1-{[4-(Methoxycarbonylamino)phenyl]sulfonyl}(3-piperidyl))-N-benzamide chemical structure, C20H23N3O5S, CAS 326607-62-9

(1-{[4-(Methoxycarbonylamino)phenyl]sulfonyl}(3-piperidyl))-N-benzamide

CAS 326607-62-9C₂₀H₂₃N₃O₅S

Methyl N-[4-({3-[(2-methoxyphenyl)carbamoyl]piperidin-1-yl}sulfonyl)phenyl]carbamate chemical structure, C21H25N3O6S, CAS 771500-15-3

Methyl N-[4-({3-[(2-methoxyphenyl)carbamoyl]piperidin-1-yl}sulfonyl)phenyl]carbamate

CAS 771500-15-3C₂₁H₂₅N₃O₆S

1-(4-Bromophenyl)sulfonyl-N-(2,4-dimethoxyphenyl)piperidine-3-carboxamide chemical structure, C20H23BrN2O5S, CAS 5869-54-5

1-(4-Bromophenyl)sulfonyl-N-(2,4-dimethoxyphenyl)piperidine-3-carboxamide

CAS 5869-54-5C₂₀H₂₃BrN₂O₅S

1-[(4-Ethoxy-3-methylphenyl)sulfonyl]-N-(4-sulfamoylphenyl)piperidine-3-carboxamide chemical structure, C21H27N3O6S2, CAS 878977-42-5

1-[(4-Ethoxy-3-methylphenyl)sulfonyl]-N-(4-sulfamoylphenyl)piperidine-3-carboxamide

CAS 878977-42-5C₂₁H₂₇N₃O₆S₂

1-[(5-Chloro-2-methoxyphenyl)sulfonyl]-N-(4-sulfamoylphenyl)piperidine-3-carboxamide chemical structure, C19H22ClN3O6S2, CAS 878986-38-0

1-[(5-Chloro-2-methoxyphenyl)sulfonyl]-N-(4-sulfamoylphenyl)piperidine-3-carboxamide

CAS 878986-38-0C₁₉H₂₂ClN₃O₆S₂

1-(4-Chlorobenzenesulfonyl)-N-(3,5-dichlorophenyl)piperidine-3-carboxamide chemical structure, C18H17Cl3N2O3S, CAS 952835-59-5

1-(4-Chlorobenzenesulfonyl)-N-(3,5-dichlorophenyl)piperidine-3-carboxamide

CAS 952835-59-5C₁₈H₁₇Cl₃N₂O₃S

N-(2,4-Difluorophenyl)-1-((4-fluorophenyl)sulfonyl)piperidine-3-carboxamide chemical structure, C18H17F3N2O3S, CAS 832139-21-6

N-(2,4-Difluorophenyl)-1-((4-fluorophenyl)sulfonyl)piperidine-3-carboxamide

CAS 832139-21-6C₁₈H₁₇F₃N₂O₃S

1-{[4-(Acetylamino)phenyl]sulfonyl}-N-(3-methoxyphenyl)-3-piperidinecarboxamide
921119-30-4C₂₁H₂₅N₃O₅S