Murcko scaffold
Ring system with 3 rings and 23 atoms
68 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 23
- Chemicals
- 68
- With full pages
- 11
Scaffold SMILES
O=C1CC(C(=O)Nc2ccccc2)SC(=Nc2ccccc2)N1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 68 chemicals
![4-[[3-Ethyl-2-(2-methoxyphenyl)imino-4-oxo-1,3-thiazinane-6-carbonyl]amino]benzoic acid chemical structure, C21H21N3O5S, CAS 1164474-32-1](/s/MGIYTZWSQVRRQJ-UHFFFAOYSA-N.svg)
4-[[3-Ethyl-2-(2-methoxyphenyl)imino-4-oxo-1,3-thiazinane-6-carbonyl]amino]benzoic acid
CAS 1164474-32-1C21H21N3O5S
![3-Ethyl-N-(2-fluorophenyl)-2-[(4-methoxyphenyl)imino]-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C20H20FN3O3S, CAS 401923-26-0](/s/OAFYWZHATGGDBU-UHFFFAOYSA-N.svg)
3-Ethyl-N-(2-fluorophenyl)-2-[(4-methoxyphenyl)imino]-4-oxo-1,3-thiazinane-6-carboxamide
CAS 401923-26-0C20H20FN3O3S
(2Z)-N-(4-Methoxyphenyl)-3-methyl-4-oxo-2-(phenylimino)-1,3-thiazinane-6-carboxamide
CAS 333327-64-3C19H19N3O3S
![2-[(3-Chloro-4-methylphenyl)imino]-N-(4-methoxyphenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C20H20ClN3O3S, CAS 335419-30-2](/s/FDHVPWGXQWGQEY-UHFFFAOYSA-N.svg)
2-[(3-Chloro-4-methylphenyl)imino]-N-(4-methoxyphenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 335419-30-2C20H20ClN3O3S
![(2Z)-N-(3-Chlorophenyl)-2-[(3-methoxyphenyl)imino]-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C19H18ClN3O3S, CAS 335419-40-4](/s/HRXANZMMHZYOBH-UHFFFAOYSA-N.svg)
(2Z)-N-(3-Chlorophenyl)-2-[(3-methoxyphenyl)imino]-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 335419-40-4C19H18ClN3O3S
![Ethyl 4-{[(2Z)-3-methyl-4-oxo-6-(phenylcarbamoyl)-1,3-thiazinan-2-ylidene]amino}benzoate chemical structure, C21H21N3O4S, CAS 333327-71-2](/s/PEUKKNBVCVXXGO-UHFFFAOYSA-N.svg)
Ethyl 4-{[(2Z)-3-methyl-4-oxo-6-(phenylcarbamoyl)-1,3-thiazinan-2-ylidene]amino}benzoate
CAS 333327-71-2C21H21N3O4S
![2-[(4-Bromophenyl)imino]-3-methyl-4-oxo-N-phenyl-1,3-thiazinane-6-carboxamide chemical structure, C18H16BrN3O2S, CAS 335419-42-6](/s/GDRMXBDHICLWAY-UHFFFAOYSA-N.svg)
2-[(4-Bromophenyl)imino]-3-methyl-4-oxo-N-phenyl-1,3-thiazinane-6-carboxamide
CAS 335419-42-6C18H16BrN3O2S
![4-[({(2Z)-2-[(3-Methoxyphenyl)imino]-3-methyl-4-oxo-1,3-thiazinan-6-yl}carbonyl)amino]benzoic acid chemical structure, C20H19N3O5S, CAS 333327-78-9](/s/FQQOHIAVKAHSBS-UHFFFAOYSA-N.svg)
4-[({(2Z)-2-[(3-Methoxyphenyl)imino]-3-methyl-4-oxo-1,3-thiazinan-6-yl}carbonyl)amino]benzoic acid
CAS 333327-78-9C20H19N3O5S
![4-[({2-[(3-Chlorophenyl)imino]-3-methyl-4-oxo-1,3-thiazinan-6-yl}carbonyl)amino]benzoic acid chemical structure, C19H16ClN3O4S, CAS 333327-79-0](/s/KUOJRUSEVSFICE-UHFFFAOYSA-N.svg)
4-[({2-[(3-Chlorophenyl)imino]-3-methyl-4-oxo-1,3-thiazinan-6-yl}carbonyl)amino]benzoic acid
CAS 333327-79-0C19H16ClN3O4S
![4-[({(2Z)-2-[(3-Fluorophenyl)imino]-3-methyl-4-oxo-1,3-thiazinan-6-yl}carbonyl)amino]benzoic acid chemical structure, C19H16FN3O4S, CAS 333327-80-3](/s/HIISQNGURCZBMM-UHFFFAOYSA-N.svg)
4-[({(2Z)-2-[(3-Fluorophenyl)imino]-3-methyl-4-oxo-1,3-thiazinan-6-yl}carbonyl)amino]benzoic acid
CAS 333327-80-3C19H16FN3O4S
![(2Z)-N-(4-Fluorophenyl)-2-[(4-methoxyphenyl)imino]-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C19H18FN3O3S, CAS 3085544-60-8](/s/XTZWMAPAKWTAHT-UHFFFAOYSA-N.svg)
(2Z)-N-(4-Fluorophenyl)-2-[(4-methoxyphenyl)imino]-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 3085544-60-8C19H18FN3O3S
![(2Z)-2-[(4-Ethoxyphenyl)imino]-N-(4-fluorophenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C20H20FN3O3S, CAS 335419-48-2](/s/NOBKCJMWWDRNIK-UHFFFAOYSA-N.svg)
(2Z)-2-[(4-Ethoxyphenyl)imino]-N-(4-fluorophenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 335419-48-2C20H20FN3O3S
![Ethyl 4-({6-[(4-fluoroanilino)carbonyl]-3-methyl-4-oxo-1,3-thiazinan-2-ylidene}amino)benzoate chemical structure, C21H20FN3O4S, CAS 335419-50-6](/s/AMAYHHYQYKBRFH-UHFFFAOYSA-N.svg)
Ethyl 4-({6-[(4-fluoroanilino)carbonyl]-3-methyl-4-oxo-1,3-thiazinan-2-ylidene}amino)benzoate
CAS 335419-50-6C21H20FN3O4S
![(2Z)-N-(4-Bromophenyl)-2-[(3-methoxyphenyl)imino]-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C19H18BrN3O3S, CAS 335419-56-2](/s/COLOKLUIMFNEFJ-UHFFFAOYSA-N.svg)
(2Z)-N-(4-Bromophenyl)-2-[(3-methoxyphenyl)imino]-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 335419-56-2C19H18BrN3O3S
N-(4-Chlorophenyl)-2-(4-methoxyphenyl)imino-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 335419-58-4C19H18ClN3O3S
![(2Z)-2-[(3,4-Dimethylphenyl)imino]-N-(2-methoxyphenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C21H23N3O3S, CAS 333328-02-2](/s/IDSQYDJSSDZXIP-UHFFFAOYSA-N.svg)
(2Z)-2-[(3,4-Dimethylphenyl)imino]-N-(2-methoxyphenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 333328-02-2C21H23N3O3S
![(2Z)-N-(4-Ethoxyphenyl)-2-[(4-fluorophenyl)imino]-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C20H20FN3O3S, CAS 333328-05-5](/s/WKBYBGLRPPMGEJ-UHFFFAOYSA-N.svg)
(2Z)-N-(4-Ethoxyphenyl)-2-[(4-fluorophenyl)imino]-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 333328-05-5C20H20FN3O3S
![(2Z)-2-[(4-Chlorophenyl)imino]-N-(4-ethoxyphenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C20H20ClN3O3S, CAS 335419-68-6](/s/SBCWTFVNFNTVLJ-UHFFFAOYSA-N.svg)
(2Z)-2-[(4-Chlorophenyl)imino]-N-(4-ethoxyphenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 335419-68-6C20H20ClN3O3S
N-(2-Fluorophenyl)-3-methyl-4-oxo-2-phenylimino-1,3-thiazinane-6-carboxamide
CAS 333328-07-7C18H16FN3O2S
![2-[(4-Chlorophenyl)imino]-N-(2-fluorophenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C18H15ClFN3O2S, CAS 405902-90-1](/s/DNJIFMSWEIFATI-UHFFFAOYSA-N.svg)
2-[(4-Chlorophenyl)imino]-N-(2-fluorophenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 405902-90-1C18H15ClFN3O2S
![N-(2-Fluorophenyl)-2-[(3-fluorophenyl)imino]-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C18H15F2N3O2S, CAS 442536-71-2](/s/RCBOCJCXFBQIMZ-UHFFFAOYSA-N.svg)
N-(2-Fluorophenyl)-2-[(3-fluorophenyl)imino]-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 442536-71-2C18H15F2N3O2S
![2-[(3,4-Dimethylphenyl)imino]-N-(2-fluorophenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C20H20FN3O2S, CAS 333328-16-8](/s/JEPRITQLTIPOTQ-UHFFFAOYSA-N.svg)
2-[(3,4-Dimethylphenyl)imino]-N-(2-fluorophenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 333328-16-8C20H20FN3O2S
![2-[(4-Chlorophenyl)imino]-N-(3-ethoxyphenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C20H20ClN3O3S, CAS 335419-76-6](/s/BHZVWXQMJFMEJZ-UHFFFAOYSA-N.svg)
2-[(4-Chlorophenyl)imino]-N-(3-ethoxyphenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 335419-76-6C20H20ClN3O3S
![N-(3-Ethoxyphenyl)-2-[(3-methoxyphenyl)imino]-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C21H23N3O4S, CAS 333328-22-6](/s/QGPVBOLNRLRVIC-UHFFFAOYSA-N.svg)
N-(3-Ethoxyphenyl)-2-[(3-methoxyphenyl)imino]-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide
CAS 333328-22-6C21H23N3O4S
- Ethyl 4-[({2-[(3-fluorophenyl)imino]-3-methyl-4-oxo-1,3-thiazinan-6-yl}carbonyl)amino]benzoate335419-84-6C21H20FN3O4S
- (2Z)-N-(3-Methoxyphenyl)-3-methyl-4-oxo-2-(phenylimino)-1,3-thiazinane-6-carboxamide333328-26-0C19H19N3O3S
- (2Z)-3-Ethyl-2-[(4-methoxyphenyl)imino]-4-oxo-N-phenyl-1,3-thiazinane-6-carboxamide401923-23-7C20H21N3O3S
- 4-(3-Ethyl-4-oxo-6-phenylcarbamoyl-[1,3]thiazinan-2-ylideneamino)-benzoic acid methyl ester384799-76-2C21H21N3O4S
- (2Z)-3-Ethyl-2-[(3-fluorophenyl)imino]-4-oxo-N-phenyl-1,3-thiazinane-6-carboxamide385386-04-9C19H18FN3O2S
- (2Z)-3-Ethyl-N-(4-methoxyphenyl)-2-[(4-methoxyphenyl)imino]-4-oxo-1,3-thiazinane-6-carboxamide401923-30-6C21H23N3O4S
- (2Z)-3-Ethyl-2-[(3-fluorophenyl)imino]-N-(4-methoxyphenyl)-4-oxo-1,3-thiazinane-6-carboxamide491855-72-2C20H20FN3O3S
- 4-[({3-Ethyl-2-[(4-methoxyphenyl)imino]-4-oxo-1,3-thiazinan-6-yl}carbonyl)amino]benzoic acid442554-80-5C21H21N3O5S
- N-(3-Ethoxyphenyl)-3-ethyl-2-[(4-methoxyphenyl)imino]-4-oxo-1,3-thiazinane-6-carboxamide491855-74-4C22H25N3O4S
- N-(4-Chlorophenyl)-2-(3,5-dichloro-4-hydroxyphenyl)imino-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide442629-46-1C18H14Cl3N3O3S
- 2-({4-[Chloro(difluoro)methoxy]phenyl}imino)-N-(2,4-dimethylphenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide442632-95-3C21H20ClF2N3O3S
- (2Z)-N-(4-Ethoxyphenyl)-3-ethyl-2-[(3-fluorophenyl)imino]-4-oxo-1,3-thiazinane-6-carboxamide442872-90-4C21H22FN3O3S
- 2-[(3,5-Dichlorophenyl)imino]-3-ethyl-N-(3-methoxyphenyl)-4-oxo-1,3-thiazinane-6-carboxamide385418-80-4C20H19Cl2N3O3S
- N-[4-[Chloro(difluoro)methoxy]phenyl]-2-(4-ethoxyphenyl)imino-3-ethyl-4-oxo-1,3-thiazinane-6-carboxamide442632-96-4C22H22ClF2N3O4S
- 2-{[4-Chloro-3-(trifluoromethyl)phenyl]imino}-3-methyl-N-(3-methylphenyl)-4-oxo-1,3-thiazinane-6-carboxamide442872-91-5C20H17ClF3N3O2S
- 2-(3,5-Dichloro-4-hydroxyphenyl)imino-N-(3-ethoxyphenyl)-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide6153-07-7C20H19Cl2N3O4S
- 2-[(4-Ethylphenyl)amino]-N-(4-methoxyphenyl)-4-oxo-5,6-dihydro-4H-1,3-thiazine-6-carboxamide433948-10-8C20H21N3O3S
- Dimethyl 5-(((2-((2,5-bis(methyloxy)phenyl)amino)-4-oxo-5,6-dihydro-4H-1,3-thiazin-6-yl)carbonyl)amino)-1,3-benzenedicarboxylate585553-44-2C23H23N3O8S
- 4-Oxo-2-(phenylamino)-N-[3-(trifluoromethyl)phenyl]-5,6-dihydro-4H-1,3-thiazine-6-carboxamide714292-63-4C18H14F3N3O2S
- N-(3,4-Dichlorophenyl)-2-[(4-methylphenyl)amino]-4-oxo-5,6-dihydro-4H-1,3-thiazine-6-carboxamide375353-49-4C18H15Cl2N3O2S
- Dimethyl 5-[({2-[(4-methoxyphenyl)amino]-4-oxo-5,6-dihydro-4H-1,3-thiazin-6-yl}carbonyl)amino]benzene-1,3-dicarboxylate578723-89-4C22H21N3O7S
- 2-[(3-Chloro-4-fluorophenyl)amino]-N-(5-chloro-2-methoxyphenyl)-4-oxo-5,6-dihydro-4H-1,3-thiazine-6-carboxamide578698-27-8C18H14Cl2FN3O3S
- N-(4-Chlorophenyl)-2-(4-methoxyanilino)-4-oxo-5,6-dihydro-4H-1,3-thiazine-6-carboxamide374912-53-5C18H16ClN3O3S
- 2-[(2,5-Dimethoxyphenyl)amino]-N-(2-ethylphenyl)-4-oxo-5,6-dihydro-4H-1,3-thiazine-6-carboxamide364381-49-7C21H23N3O4S
Related scaffolds
Same ring framework with different atoms or bond orders
C(=Cc1cccc(OC2CCCCO2)c1)c1ccccc112 chemicals
O=C(Nc1ccccc1)c1cccc(S(=O)(=O)N2CCOCC2)c111 chemicals
c1ccc(Nc2ncnc(CSc3ncccn3)n2)cc110 chemicals
O=C1CCC(C=Cc2ccccc2)=NN1Cc1ccccc110 chemicals
O=C(Nc1cccc(S(=O)(=O)N2CCCCC2)c1)c1cccnc19 chemicals
c1ccc(OC2CCCC(COC3CCCCO3)O2)cc18 chemicals
O=C(Nc1ccccc1)c1cccc(S(=O)(=O)N2CCCCC2)c18 chemicals
O=c1ccc(C=Cc2ccccc2)nn1Cc1ccccc18 chemicals
O=C(Nc1cccc(S(=O)(=O)N2CCOCC2)c1)c1cccnc16 chemicals
O=c1ccn(Cc2ccccc2)cc1OCc1ccccc16 chemicals
O=C(c1cccc(S(=O)(=O)Nc2ccccc2)c1)N1CCOCC15 chemicals
O=C(Nc1cccc(S(=O)(=O)N2CCOCC2)c1)c1ccccc15 chemicals