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Murcko scaffold

(4-Phenylpiperazin-1-yl)[2-(pyridin-3-yl)quinolin-4-yl]methanone scaffold

18 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
30
Chemicals
18
With full pages
2
Scaffold SMILES

O=C(c1cc(-c2cccnc2)nc2ccccc12)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the (4-Phenylpiperazin-1-yl)[2-(pyridin-3-yl)quinolin-4-yl]methanone page
Murcko scaffold O=C(c1cc(-c2cccnc2)nc2ccccc12)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

(7,8-Dimethyl-2-pyridin-3-ylquinolin-4-yl)-(4-phenylpiperazin-1-yl)methanone chemical structure, C27H26N4O, CAS 713116-96-2
(7,8-Dimethyl-2-pyridin-3-ylquinolin-4-yl)-(4-phenylpiperazin-1-yl)methanone
CAS 713116-96-2C27H26N4O
1-[4-[4-[[6-Bromo-2-(3-pyridinyl)-4-quinolinyl]-oxomethyl]-1-piperazinyl]phenyl]ethanone chemical structure, C27H23BrN4O2, CAS 713489-86-2
1-[4-[4-[[6-Bromo-2-(3-pyridinyl)-4-quinolinyl]-oxomethyl]-1-piperazinyl]phenyl]ethanone
CAS 713489-86-2C27H23BrN4O2
[4-(2-Fluorophenyl)piperazin-1-yl][6-methyl-2-(pyridin-3-yl)quinolin-4-yl]methanone chemical structure, C26H23FN4O, CAS 667443-29-0
[4-(2-Fluorophenyl)piperazin-1-yl][6-methyl-2-(pyridin-3-yl)quinolin-4-yl]methanone
CAS 667443-29-0C26H23FN4O
[6-Methyl-2-(pyridin-3-yl)quinolin-4-yl](4-phenylpiperazin-1-yl)methanone chemical structure, C26H24N4O, CAS 667443-39-2
[6-Methyl-2-(pyridin-3-yl)quinolin-4-yl](4-phenylpiperazin-1-yl)methanone
CAS 667443-39-2C26H24N4O
[4-(3-Chlorophenyl)piperazin-1-yl][6-methyl-2-(pyridin-3-yl)quinolin-4-yl]methanone chemical structure, C26H23ClN4O, CAS 667443-41-6
[4-(3-Chlorophenyl)piperazin-1-yl][6-methyl-2-(pyridin-3-yl)quinolin-4-yl]methanone
CAS 667443-41-6C26H23ClN4O
[7-Chloro-8-methyl-2-(pyridin-3-yl)quinolin-4-yl][4-(4-chlorophenyl)piperazin-1-yl]methanone chemical structure, C26H22Cl2N4O, CAS 669705-11-7
[7-Chloro-8-methyl-2-(pyridin-3-yl)quinolin-4-yl][4-(4-chlorophenyl)piperazin-1-yl]methanone
CAS 669705-11-7C26H22Cl2N4O
[7-Chloro-8-methyl-2-(pyridin-3-yl)quinolin-4-yl][4-(4-fluorophenyl)piperazin-1-yl]methanone chemical structure, C26H22ClFN4O, CAS 669705-15-1
[7-Chloro-8-methyl-2-(pyridin-3-yl)quinolin-4-yl][4-(4-fluorophenyl)piperazin-1-yl]methanone
CAS 669705-15-1C26H22ClFN4O
[4-(4-Methoxyphenyl)piperazin-1-yl][8-methyl-2-(pyridin-3-yl)quinolin-4-yl]methanone chemical structure, C27H26N4O2, CAS 669705-29-7
[4-(4-Methoxyphenyl)piperazin-1-yl][8-methyl-2-(pyridin-3-yl)quinolin-4-yl]methanone
CAS 669705-29-7C27H26N4O2
[4-(3-Chlorophenyl)piperazin-1-yl][8-methyl-2-(pyridin-3-yl)quinolin-4-yl]methanone chemical structure, C26H23ClN4O, CAS 669708-96-7
[4-(3-Chlorophenyl)piperazin-1-yl][8-methyl-2-(pyridin-3-yl)quinolin-4-yl]methanone
CAS 669708-96-7C26H23ClN4O
[4-(2-Fluorophenyl)piperazin-1-yl][8-methyl-2-(pyridin-3-yl)quinolin-4-yl]methanone chemical structure, C26H23FN4O, CAS 669708-98-9
[4-(2-Fluorophenyl)piperazin-1-yl][8-methyl-2-(pyridin-3-yl)quinolin-4-yl]methanone
CAS 669708-98-9C26H23FN4O
[8-Methyl-2-(pyridin-3-yl)quinolin-4-yl](4-phenylpiperazin-1-yl)methanone chemical structure, C26H24N4O, CAS 669709-04-0
[8-Methyl-2-(pyridin-3-yl)quinolin-4-yl](4-phenylpiperazin-1-yl)methanone
CAS 669709-04-0C26H24N4O
[7-Chloro-8-methyl-2-(pyridin-3-yl)quinolin-4-yl](4-phenylpiperazin-1-yl)methanone chemical structure, C26H23ClN4O, CAS 669725-87-5
[7-Chloro-8-methyl-2-(pyridin-3-yl)quinolin-4-yl](4-phenylpiperazin-1-yl)methanone
CAS 669725-87-5C26H23ClN4O
[6-Chloro-2-(pyridin-3-yl)quinolin-4-yl][4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C26H23ClN4O2, CAS 669729-03-7
[6-Chloro-2-(pyridin-3-yl)quinolin-4-yl][4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 669729-03-7C26H23ClN4O2
[4-(2-Methoxyphenyl)piperazin-1-yl][2-(pyridin-3-yl)quinolin-4-yl]methanone chemical structure, C26H24N4O2, CAS 1180586-82-6
[4-(2-Methoxyphenyl)piperazin-1-yl][2-(pyridin-3-yl)quinolin-4-yl]methanone
CAS 1180586-82-6C26H24N4O2
(4-Phenylpiperazin-1-yl)[2-(pyridin-3-yl)quinolin-4-yl]methanone chemical structure, C25H22N4O, CAS 1043205-16-8
(4-Phenylpiperazin-1-yl)[2-(pyridin-3-yl)quinolin-4-yl]methanone
CAS 1043205-16-8C25H22N4O
[4-(4-Methoxyphenyl)piperazino][2-(3-pyridyl)-4-quinolyl]methanone chemical structure, C26H24N4O2, CAS 1144448-62-3
[4-(4-Methoxyphenyl)piperazino][2-(3-pyridyl)-4-quinolyl]methanone
CAS 1144448-62-3C26H24N4O2
[4-(3-Chlorophenyl)piperazino][2-(3-pyridyl)-4-quinolyl]methanone chemical structure, C25H21ClN4O, CAS 1144461-72-2
[4-(3-Chlorophenyl)piperazino][2-(3-pyridyl)-4-quinolyl]methanone
CAS 1144461-72-2C25H21ClN4O
[4-(4-Fluorophenyl)piperazin-1-yl][2-(pyridin-3-yl)quinolin-4-yl]methanone chemical structure, C25H21FN4O, CAS 1144488-69-6
[4-(4-Fluorophenyl)piperazin-1-yl][2-(pyridin-3-yl)quinolin-4-yl]methanone
CAS 1144488-69-6C25H21FN4O