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Murcko scaffold

(4-Phenylpiperazin-1-yl)(2-phenylquinolin-4-yl)methanone scaffold

105 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
30
Chemicals
105
With full pages
4
Scaffold SMILES

O=C(c1cc(-c2ccccc2)nc2ccccc12)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the (4-Phenylpiperazin-1-yl)(2-phenylquinolin-4-yl)methanone page
Murcko scaffold O=C(c1cc(-c2ccccc2)nc2ccccc12)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 105 chemicals

[4-(2-Ethoxyphenyl)piperazin-1-yl]-[2-(3-ethoxyphenyl)quinolin-4-yl]methanone chemical structure, C30H31N3O3, CAS 350999-65-4
[4-(2-Ethoxyphenyl)piperazin-1-yl]-[2-(3-ethoxyphenyl)quinolin-4-yl]methanone
CAS 350999-65-4C30H31N3O3
[6-Bromo-2-(3-methylphenyl)quinolin-4-yl]-(4-phenylpiperazin-1-yl)methanone chemical structure, C27H24BrN3O, CAS 438213-19-5
[6-Bromo-2-(3-methylphenyl)quinolin-4-yl]-(4-phenylpiperazin-1-yl)methanone
CAS 438213-19-5C27H24BrN3O
[4-(2-Methoxyphenyl)piperazin-1-yl]-[2-(4-propan-2-ylphenyl)quinolin-4-yl]methanone chemical structure, C30H31N3O2, CAS 445236-13-5
[4-(2-Methoxyphenyl)piperazin-1-yl]-[2-(4-propan-2-ylphenyl)quinolin-4-yl]methanone
CAS 445236-13-5C30H31N3O2
[6-Bromo-2-(4-ethoxyphenyl)quinolin-4-yl]-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C29H28BrN3O3, CAS 445236-58-8
[6-Bromo-2-(4-ethoxyphenyl)quinolin-4-yl]-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 445236-58-8C29H28BrN3O3
1-[4-[4-[6-Bromo-2-(4-methoxyphenyl)quinoline-4-carbonyl]piperazin-1-yl]phenyl]ethanone chemical structure, C29H26BrN3O3, CAS 438221-92-2
1-[4-[4-[6-Bromo-2-(4-methoxyphenyl)quinoline-4-carbonyl]piperazin-1-yl]phenyl]ethanone
CAS 438221-92-2C29H26BrN3O3
4-{[4-(4-Fluorophenyl)-1-piperazinyl]carbonyl}-2-phenylquinoline chemical structure, C26H22FN3O, CAS 312598-95-1
4-{[4-(4-Fluorophenyl)-1-piperazinyl]carbonyl}-2-phenylquinoline
CAS 312598-95-1C26H22FN3O
[2-(4-Ethoxyphenyl)-6-methylquinolin-4-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C29H28FN3O2, CAS 438233-84-2
[2-(4-Ethoxyphenyl)-6-methylquinolin-4-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 438233-84-2C29H28FN3O2
[2-(4-Ethoxyphenyl)-6-methylquinolin-4-yl]-(4-phenylpiperazin-1-yl)methanone chemical structure, C29H29N3O2, CAS 438232-61-2
[2-(4-Ethoxyphenyl)-6-methylquinolin-4-yl]-(4-phenylpiperazin-1-yl)methanone
CAS 438232-61-2C29H29N3O2
[4-(2-Fluorophenyl)piperazin-1-yl]-[3-methyl-2-(4-methylphenyl)quinolin-4-yl]methanone chemical structure, C28H26FN3O, CAS 545439-10-9
[4-(2-Fluorophenyl)piperazin-1-yl]-[3-methyl-2-(4-methylphenyl)quinolin-4-yl]methanone
CAS 545439-10-9C28H26FN3O
4-{[4-(3-Chlorophenyl)-1-piperazinyl]carbonyl}-2-(3,4-dimethoxyphenyl)quinoline chemical structure, C28H26ClN3O3, CAS 544662-95-5
4-{[4-(3-Chlorophenyl)-1-piperazinyl]carbonyl}-2-(3,4-dimethoxyphenyl)quinoline
CAS 544662-95-5C28H26ClN3O3
[4-(2-Fluorophenyl)piperazin-1-yl]-(2-phenylquinolin-4-yl)methanone chemical structure, C26H22FN3O, CAS 355001-62-6
[4-(2-Fluorophenyl)piperazin-1-yl]-(2-phenylquinolin-4-yl)methanone
CAS 355001-62-6C26H22FN3O
[2-(2,4-Dimethylphenyl)quinolin-4-yl]-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C29H29N3O2, CAS 543703-22-6
[2-(2,4-Dimethylphenyl)quinolin-4-yl]-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 543703-22-6C29H29N3O2
[2-(2,5-Dimethylphenyl)quinolin-4-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C28H26FN3O, CAS 438532-55-9
[2-(2,5-Dimethylphenyl)quinolin-4-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 438532-55-9C28H26FN3O
[4-(4-Chlorophenyl)piperazin-1-yl]-[2-(3-methylphenyl)quinolin-4-yl]methanone chemical structure, C27H24ClN3O, CAS 354546-25-1
[4-(4-Chlorophenyl)piperazin-1-yl]-[2-(3-methylphenyl)quinolin-4-yl]methanone
CAS 354546-25-1C27H24ClN3O
[4-(3-Chlorophenyl)piperazin-1-yl]-(2-phenylquinolin-4-yl)methanone chemical structure, C26H22ClN3O, CAS 346727-25-1
[4-(3-Chlorophenyl)piperazin-1-yl]-(2-phenylquinolin-4-yl)methanone
CAS 346727-25-1C26H22ClN3O
[2-(4-Ethoxyphenyl)quinolin-4-yl]-[4-(4-fluorophenyl)piperazin-1-yl]methanone chemical structure, C28H26FN3O2, CAS 330852-12-5
[2-(4-Ethoxyphenyl)quinolin-4-yl]-[4-(4-fluorophenyl)piperazin-1-yl]methanone
CAS 330852-12-5C28H26FN3O2
[4-(4-Fluorophenyl)piperazin-1-yl]-[2-(3-methoxyphenyl)quinolin-4-yl]methanone chemical structure, C27H24FN3O2, CAS 313703-12-7
[4-(4-Fluorophenyl)piperazin-1-yl]-[2-(3-methoxyphenyl)quinolin-4-yl]methanone
CAS 313703-12-7C27H24FN3O2
[4-(3-Chlorophenyl)piperazin-1-yl]-[2-(4-ethoxyphenyl)quinolin-4-yl]methanone chemical structure, C28H26ClN3O2, CAS 303136-60-9
[4-(3-Chlorophenyl)piperazin-1-yl]-[2-(4-ethoxyphenyl)quinolin-4-yl]methanone
CAS 303136-60-9C28H26ClN3O2
[4-(2-Methoxyphenyl)piperazin-1-yl]-[2-(4-methoxyphenyl)quinolin-4-yl]methanone chemical structure, C28H27N3O3, CAS 303139-09-5
[4-(2-Methoxyphenyl)piperazin-1-yl]-[2-(4-methoxyphenyl)quinolin-4-yl]methanone
CAS 303139-09-5C28H27N3O3
[2-(4-Ethylphenyl)quinolin-4-yl]-(4-phenylpiperazin-1-yl)methanone chemical structure, C28H27N3O, CAS 354997-75-4
[2-(4-Ethylphenyl)quinolin-4-yl]-(4-phenylpiperazin-1-yl)methanone
CAS 354997-75-4C28H27N3O
[2-(4-Ethylphenyl)quinolin-4-yl]-[4-(4-fluorophenyl)piperazin-1-yl]methanone chemical structure, C28H26FN3O, CAS 352688-39-2
[2-(4-Ethylphenyl)quinolin-4-yl]-[4-(4-fluorophenyl)piperazin-1-yl]methanone
CAS 352688-39-2C28H26FN3O
[2-(3-Ethoxyphenyl)quinolin-4-yl]-[4-(4-fluorophenyl)piperazin-1-yl]methanone chemical structure, C28H26FN3O2, CAS 350998-34-4
[2-(3-Ethoxyphenyl)quinolin-4-yl]-[4-(4-fluorophenyl)piperazin-1-yl]methanone
CAS 350998-34-4C28H26FN3O2
[4-(2-Fluorophenyl)piperazin-1-yl]-(6-methyl-2-phenylquinolin-4-yl)methanone chemical structure, C27H24FN3O, CAS 774591-40-1
[4-(2-Fluorophenyl)piperazin-1-yl]-(6-methyl-2-phenylquinolin-4-yl)methanone
CAS 774591-40-1C27H24FN3O
[2-(4-Ethylphenyl)-3-methylquinolin-4-yl]-[4-(4-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C30H31N3O2, CAS 713119-43-8
[2-(4-Ethylphenyl)-3-methylquinolin-4-yl]-[4-(4-methoxyphenyl)piperazin-1-yl]methanone
CAS 713119-43-8C30H31N3O2